Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0166 | 0.6036 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0088 | 0.3039 | 0.5035 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0012 | 0.0147 | 0.0244 |
Echinococcus granulosus | FTZ F1 alpha | 0.0166 | 0.6036 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0166 | 0.6036 | 1 |
Brugia malayi | steroid hormone receptor | 0.0166 | 0.6036 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0166 | 0.6036 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0088 | 0.3039 | 0.5035 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0039 | 0.118 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0166 | 0.6036 | 0.6036 |
Brugia malayi | ecdysteroid receptor | 0.0166 | 0.6036 | 1 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0079 | 0.268 | 0.268 |
Schistosoma mansoni | nuclear hormone receptor | 0.0079 | 0.268 | 0.268 |
Brugia malayi | hypothetical protein | 0.0079 | 0.268 | 0.444 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0166 | 0.6036 | 0.6036 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0166 | 0.6036 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0166 | 0.6036 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.6036 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0166 | 0.6036 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0166 | 0.6036 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0166 | 0.6036 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0166 | 0.6036 | 1 |
Brugia malayi | hypothetical protein | 0.0079 | 0.268 | 0.444 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0166 | 0.6036 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0079 | 0.268 | 0.444 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0166 | 0.6036 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1074 | 0.1779 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.268 | 0.444 |
Brugia malayi | nuclear receptor RXR | 0.0088 | 0.3039 | 0.5035 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0166 | 0.6036 | 1 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0012 | 0.0147 | 0.0244 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0166 | 0.6036 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0166 | 0.6036 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0166 | 0.6036 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0166 | 0.6036 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0166 | 0.6036 | 0.6036 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0079 | 0.268 | 0.444 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.3039 | 0.5035 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0166 | 0.6036 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0166 | 0.6036 | 0.6036 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0088 | 0.3039 | 0.5035 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.6036 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0166 | 0.6036 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0166 | 0.6036 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.3039 | 0.5035 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.268 | 0.444 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0012 | 0.0147 | 0.0244 |
Brugia malayi | nuclear hormone receptor | 0.0166 | 0.6036 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.6036 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0079 | 0.268 | 0.444 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0088 | 0.3039 | 0.5035 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0166 | 0.6036 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.6036 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0166 | 0.6036 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0166 | 0.6036 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.3039 | 0.5035 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0079 | 0.268 | 0.268 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.268 | 0.444 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.268 | 0.444 |
Schistosoma mansoni | thyroid hormone receptor | 0.0166 | 0.6036 | 0.6036 |
Brugia malayi | conserved hypotetical protein | 0.0079 | 0.268 | 0.444 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0079 | 0.268 | 0.444 |
Brugia malayi | hypothetical protein | 0.0088 | 0.3039 | 0.5035 |
Echinococcus granulosus | voltage gated potassium channel | 0.0012 | 0.0147 | 0.0244 |
Brugia malayi | nuclear receptor NHR-67 | 0.0079 | 0.268 | 0.444 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0166 | 0.6036 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0079 | 0.268 | 0.444 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0166 | 0.6036 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0166 | 0.6036 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0166 | 0.6036 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0166 | 0.6036 | 0.6036 |
Schistosoma mansoni | nuclear hormone receptor | 0.0079 | 0.268 | 0.268 |
Schistosoma mansoni | nuclear receptor | 0.0079 | 0.268 | 0.268 |
Schistosoma mansoni | coup transcription factor | 0.0166 | 0.6036 | 0.6036 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0079 | 0.268 | 0.444 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0166 | 0.6036 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0147 | 0.0244 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0046 | 0.1433 | 0.1433 |
Loa Loa (eye worm) | DR-78 | 0.0079 | 0.268 | 0.444 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.6036 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0079 | 0.268 | 0.444 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0166 | 0.6036 | 1 |
Brugia malayi | hypothetical protein | 0.0088 | 0.3039 | 0.5035 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.268 | 0.444 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.3039 | 0.5035 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.6036 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.268 | 0.444 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0079 | 0.268 | 0.444 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0166 | 0.6036 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0166 | 0.6036 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0166 | 0.6036 | 0.6036 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0079 | 0.268 | 0.444 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0088 | 0.3039 | 0.3039 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0166 | 0.6036 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.268 | 0.444 |
Schistosoma mansoni | nuclear receptor | 0.0079 | 0.268 | 0.268 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0166 | 0.6036 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0042 | 0.1285 | 0.213 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0166 | 0.6036 | 0.6036 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0042 | 0.1285 | 0.213 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0166 | 0.6036 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0166 | 0.6036 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0046 | 0.1433 | 0.1433 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0166 | 0.6036 | 0.6036 |
Brugia malayi | nuclear receptor NHR-88 | 0.0166 | 0.6036 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.268 | 0.444 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.268 | 0.444 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.268 | 0.444 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0012 | 0.0147 | 0.0147 |
Brugia malayi | nuclear hormone receptor | 0.0079 | 0.268 | 0.444 |
Brugia malayi | tailless protein | 0.0079 | 0.268 | 0.444 |
Onchocerca volvulus | 0.0166 | 0.6036 | 1 | |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0166 | 0.6036 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0166 | 0.6036 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.6036 | 1 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0079 | 0.268 | 0.444 |
Schistosoma mansoni | zinc finger protein | 0.0079 | 0.268 | 0.268 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.268 | 0.444 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0088 | 0.3039 | 0.5035 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0042 | 0.1285 | 0.213 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0166 | 0.6036 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0166 | 0.6036 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0079 | 0.268 | 0.444 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0079 | 0.268 | 0.444 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0079 | 0.268 | 0.444 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0166 | 0.6036 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0079 | 0.268 | 0.444 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.268 | 0.444 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0079 | 0.268 | 0.444 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0166 | 0.6036 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.268 | 0.444 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0166 | 0.6036 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0012 | 0.0147 | 0.0244 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0166 | 0.6036 | 1 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0079 | 0.268 | 0.268 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0079 | 0.268 | 0.444 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0079 | 0.268 | 0.444 |
Brugia malayi | ecdysone receptor | 0.0079 | 0.268 | 0.444 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0079 | 0.268 | 0.444 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0079 | 0.268 | 0.444 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0079 | 0.268 | 0.444 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0042 | 0.1285 | 0.213 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0079 | 0.268 | 0.444 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0012 | 0.0147 | 0.0147 |
Trypanosoma brucei | RNA helicase, putative | 0.027 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.3039 | 0.5035 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0079 | 0.268 | 0.444 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0088 | 0.3039 | 0.3039 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0039 | 0.118 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0166 | 0.6036 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.6036 | 1 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0079 | 0.268 | 0.444 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0166 | 0.6036 | 0.6036 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0166 | 0.6036 | 0.6036 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0166 | 0.6036 | 0.6036 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0166 | 0.6036 | 1 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 23920246 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.