Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Sus scrofa | Aminopeptidase N | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Loa Loa (eye worm) | peptidase family M1 containing protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Onchocerca volvulus | Get druggable targets OG5_127217 | All targets in OG5_127217 | |
Schistosoma japonicum | ko:K01256 membrane alanyl aminopeptidase [EC3.4.11.2], putative | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Echinococcus granulosus | aminopeptidase N | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Brugia malayi | Peptidase family M1 containing protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Echinococcus multilocularis | aminopeptidase N | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | puromycin sensitive aminopeptidase | Aminopeptidase N | 963 aa | 975 aa | 29.1 % |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | Aminopeptidase N | 963 aa | 988 aa | 28.5 % |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | Aminopeptidase N | 963 aa | 981 aa | 29.2 % |
Onchocerca volvulus | Aminopeptidase N | 963 aa | 893 aa | 32.0 % | |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | Aminopeptidase N | 963 aa | 981 aa | 28.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | Wee1-like protein kinase, putative | 0.0194 | 1 | 1 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0042 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.019 | 0.9743 | 1 |
Echinococcus granulosus | aminopeptidase N | 0.0143 | 0.6662 | 1 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0116 | 0.486 | 0.4988 |
Entamoeba histolytica | aminopeptidase, putative | 0.0042 | 0 | 0.5 |
Brugia malayi | Peptidase family M1 containing protein | 0.0143 | 0.6662 | 0.6838 |
Trypanosoma brucei | wee1-like protein kinase | 0.0194 | 1 | 1 |
Trypanosoma cruzi | Wee1-like protein kinase, putative | 0.0194 | 1 | 1 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.0194 | 1 | 1 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | 0.019 | 0.9743 | 1 |
Trypanosoma cruzi | Wee1-like protein kinase, putative | 0.0194 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.019 | 0.9743 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.3883 | 0.3985 |
Echinococcus multilocularis | aminopeptidase N | 0.0143 | 0.6662 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.5685 | 0.5835 |
Onchocerca volvulus | 0.0143 | 0.6662 | 1 | |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0042 | 0 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0042 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.04 uM | Inhibition of pig microsomal aminopeptidase N using L-leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after 30 mins by spectrophotometric analysis | ChEMBL. | 23860593 |
IC50 (binding) | > 1000 uM | Inhibition of HDAC1/HDAC3/HDAC5/HDAC8 in human HeLa nuclear extract using Boc-Lys(acetyl)-AMC as substrate incubated for 5 mins prior to substrate measured after 30 mins by spectrophotometric analysis | ChEMBL. | 23860593 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.