Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | diacylglycerol O-acyltransferase 1 | Starlite/ChEMBL | References |
Mus musculus | diacylglycerol O-acyltransferase 1 | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 84 % | Reduction in triglyceride excursion in mouse at 10 mg/kg, po measured at 18 hrs by lipid tolerance test | ChEMBL. | 24900745 |
IC50 (binding) | = 1.7 nM | Inhibition of human DGAT1 | ChEMBL. | 24900745 |
IC50 (binding) | = 2.2 nM | Inhibition of mouse DGAT1 | ChEMBL. | 24900745 |
IC50 (binding) | = 1093 nM | Inhibition of human ACAT1 | ChEMBL. | 24900745 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.