Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Dual specificity protein kinase TTK homolog | 0.0375 | 0.821 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0375 | 0.821 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0014 | 0.0087 | 0.5 |
Giardia lamblia | Kinase, TTK | 0.0375 | 0.821 | 0.5 |
Trypanosoma brucei | RNA helicase, putative | 0.0455 | 1 | 1 |
Echinococcus multilocularis | dual specificity serine:threonine tyrosine | 0.0375 | 0.821 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0014 | 0.0087 | 0.0106 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0375 | 0.821 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0014 | 0.0087 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0014 | 0.0087 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0014 | 0.0087 | 0.0106 |
Brugia malayi | Protein kinase domain containing protein | 0.0375 | 0.821 | 1 |
Echinococcus granulosus | dual specificity serine:threonine tyrosine | 0.0375 | 0.821 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0014 | 0.0087 | 0.5 |
Loa Loa (eye worm) | TTK protein kinase | 0.0375 | 0.821 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0014 | 0.0087 | 0.0106 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.