Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0105 | 0.5274 | 1 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0105 | 0.5274 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.0045 | 0.2081 | 0.3945 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0105 | 0.5274 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0105 | 0.5274 | 1 |
Echinococcus granulosus | glycogen phosphorylase | 0.0105 | 0.5274 | 1 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0105 | 0.5274 | 1 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0016 | 0.0493 | 0.5 |
Brugia malayi | Myb-like DNA-binding domain containing protein | 0.0187 | 0.9706 | 1 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0105 | 0.5274 | 0.1907 |
Schistosoma mansoni | glycogen phosphorylase | 0.0105 | 0.5274 | 1 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0016 | 0.0493 | 0.0936 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0016 | 0.0493 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0105 | 0.5274 | 1 |
Schistosoma mansoni | amine oxidase | 0.0016 | 0.0493 | 0.0936 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.3809 | 0.3809 |
Leishmania major | UDP-galactopyranose mutase | 0.0016 | 0.0493 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0105 | 0.5274 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0016 | 0.0493 | 1 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0045 | 0.2081 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0493 | 0.0493 |
Schistosoma mansoni | amine oxidase | 0.0016 | 0.0493 | 0.0936 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0022 | 0.0845 | 0.0871 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0078 | 0.3809 | 0.7222 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.9706 | 0.9706 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0016 | 0.0493 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.0105 | 0.5274 | 1 |
Brugia malayi | carbohydrate phosphorylase | 0.0105 | 0.5274 | 0.5434 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.3809 | 0.3809 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0016 | 0.0493 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0493 | 0.0493 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0016 | 0.0493 | 0.0936 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0078 | 0.3809 | 0.7222 |
Echinococcus multilocularis | 0.0016 | 0.0493 | 0.0936 | |
Giardia lamblia | Glycogen phosphorylase | 0.0105 | 0.5274 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0845 | 0.0845 |
Onchocerca volvulus | CoRest homolog | 0.0193 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0016 | 0.0493 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.4161 | 0.4161 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0078 | 0.3809 | 0.7222 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0493 | 0.0508 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0105 | 0.5274 | 1 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0105 | 0.5274 | 0.5 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0016 | 0.0493 | 0.5 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0016 | 0.0493 | 0.5 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0016 | 0.0493 | 0.5 |
Brugia malayi | SWIRM domain containing protein | 0.0084 | 0.4161 | 0.4287 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0045 | 0.2081 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0016 | 0.0493 | 0.5 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0016 | 0.0493 | 0.5 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0016 | 0.0493 | 0.0936 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0105 | 0.5274 | 0.5274 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0105 | 0.5274 | 1 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0016 | 0.0493 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CD50 (ADMET) | = 18 ug ml-1 | Cytotoxicity against human Jurkat cells after 72 hrs by MTT assay | ChEMBL. | 23891229 |
GI (functional) | = 75 % | Bacteriostatic activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition at 5 ug/mL relative to control | ChEMBL. | 23891229 |
GI (functional) | = 99 % | Bacteriostatic activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition at 10 ug/mL relative to control | ChEMBL. | 23891229 |
GI (functional) | = 100 % | Bacteriostatic activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition at 20 ug/mL relative to control | ChEMBL. | 23891229 |
GI (functional) | = 100 % | Bacteriostatic activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition at 100 ug/mL relative to control | ChEMBL. | 23891229 |
GI (functional) | = 100 % | Bacteriostatic activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition at 50 ug/mL relative to control | ChEMBL. | 23891229 |
MIC99 (functional) | = 10 ug ml-1 | Bacteriostatic activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition | ChEMBL. | 23891229 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.