Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Common central domain of tyrosinase family protein | 0.0095 | 0.1031 | 0.1031 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.013 | 0.2521 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.013 | 0.2521 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.013 | 0.2521 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.013 | 0.2521 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.013 | 0.2521 | 1 |
Plasmodium vivax | vivapain-2 | 0.013 | 0.2521 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.013 | 0.2521 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.013 | 0.2521 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.013 | 0.2521 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0116 | 0.1906 | 0.7559 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.013 | 0.2521 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.013 | 0.2521 | 0.1869 |
Onchocerca volvulus | 0.0095 | 0.1031 | 0.1331 | |
Onchocerca volvulus | 0.013 | 0.2521 | 1 | |
Brugia malayi | Hypothetical tyrosinase-like protein F21C3.2 in chromosome I | 0.0095 | 0.1031 | 0.1031 |
Brugia malayi | Cathepsin L-like precursor | 0.009 | 0.0802 | 0.0802 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.013 | 0.2521 | 1 |
Schistosoma mansoni | tyrosinase precursor | 0.0095 | 0.1031 | 0.1031 |
Brugia malayi | Cathepsin L-like precursor | 0.013 | 0.2521 | 0.2521 |
Entamoeba histolytica | cysteine proteinase, putative | 0.013 | 0.2521 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.013 | 0.2521 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.013 | 0.2521 | 1 |
Leishmania major | cathepsin L-like protease | 0.013 | 0.2521 | 1 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0095 | 0.1031 | 0.1031 |
Brugia malayi | ShTK domain containing protein | 0.0095 | 0.1031 | 0.1031 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.013 | 0.2521 | 0.2521 |
Echinococcus granulosus | cathepsin l1 | 0.009 | 0.0802 | 0.0802 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.013 | 0.2521 | 0.2521 |
Brugia malayi | Cathepsin L-like precursor | 0.013 | 0.2521 | 0.2521 |
Onchocerca volvulus | Cathepsin L homolog | 0.013 | 0.2521 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.013 | 0.2521 | 0.2521 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.013 | 0.2521 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.013 | 0.2521 | 0.2521 |
Onchocerca volvulus | 0.013 | 0.2521 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.013 | 0.2521 | 1 |
Onchocerca volvulus | 0.013 | 0.2521 | 1 | |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.013 | 0.2521 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.013 | 0.2521 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.013 | 0.2521 | 1 |
Loa Loa (eye worm) | fibroinase | 0.013 | 0.2521 | 0.1869 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.1031 | 0.0249 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.013 | 0.2521 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.013 | 0.2521 | 1 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0095 | 0.1031 | 0.1031 |
Leishmania major | cathepsin L-like protease | 0.013 | 0.2521 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0116 | 0.1906 | 0.7559 |
Echinococcus multilocularis | cysteine protease | 0.013 | 0.2521 | 0.2521 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.013 | 0.2521 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.013 | 0.2521 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.013 | 0.2521 | 0.2521 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.013 | 0.2521 | 1 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0095 | 0.1031 | 0.1031 |
Leishmania major | cathepsin L-like protease | 0.013 | 0.2521 | 1 |
Leishmania major | cathepsin L-like protease | 0.013 | 0.2521 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0305 | 1 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.013 | 0.2521 | 0.2521 |
Loa Loa (eye worm) | hypothetical protein | 0.0305 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0305 | 1 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.009 | 0.0802 | 0.0802 |
Echinococcus multilocularis | cathepsin b | 0.0305 | 1 | 1 |
Onchocerca volvulus | 0.013 | 0.2521 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.013 | 0.2521 | 0.2521 |
Entamoeba histolytica | cysteine protease, putative | 0.013 | 0.2521 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.009 | 0.0802 | 0.0802 |
Onchocerca volvulus | 0.013 | 0.2521 | 1 | |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0095 | 0.1031 | 0.0249 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.013 | 0.2521 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0116 | 0.1906 | 0.1906 |
Plasmodium vivax | vivapain-2 | 0.013 | 0.2521 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.013 | 0.2521 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.1031 | 0.0249 |
Entamoeba histolytica | cysteine proteinase, putative | 0.013 | 0.2521 | 1 |
Onchocerca volvulus | 0.0095 | 0.1031 | 0.1331 | |
Onchocerca volvulus | Cathepsin L homolog | 0.013 | 0.2521 | 1 |
Onchocerca volvulus | 0.0095 | 0.1031 | 0.1331 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.013 | 0.2521 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.013 | 0.2521 | 0.2521 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.013 | 0.2521 | 1 |
Onchocerca volvulus | 0.013 | 0.2521 | 1 | |
Loa Loa (eye worm) | tyrosinase 1 | 0.0095 | 0.1031 | 0.0249 |
Echinococcus multilocularis | cysteine protease | 0.013 | 0.2521 | 0.2521 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.013 | 0.2521 | 0.2521 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0305 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.013 | 0.2521 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.013 | 0.2521 | 0.2521 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.013 | 0.2521 | 0.2521 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.013 | 0.2521 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.2521 | 0.1869 |
Brugia malayi | Cathepsin L-like precursor | 0.013 | 0.2521 | 0.2521 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.013 | 0.2521 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.013 | 0.2521 | 0.1869 |
Schistosoma mansoni | tyrosinase precursor | 0.0095 | 0.1031 | 0.1031 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.013 | 0.2521 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.013 | 0.2521 | 1 |
Leishmania major | cathepsin L-like protease | 0.013 | 0.2521 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.013 | 0.2521 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.013 | 0.2521 | 0.2521 |
Giardia lamblia | Cathepsin B precursor | 0.0116 | 0.1906 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.009 | 0.0802 | 0.3182 |
Giardia lamblia | Cathepsin B precursor | 0.0116 | 0.1906 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.013 | 0.2521 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.009 | 0.0802 | 0.3182 |
Leishmania major | cathepsin L-like protease | 0.013 | 0.2521 | 1 |
Onchocerca volvulus | 0.0095 | 0.1031 | 0.1331 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.013 | 0.2521 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.009 | 0.0802 | 0.3182 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.013 | 0.2521 | 0.2521 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0116 | 0.1906 | 0.1906 |
Giardia lamblia | Cathepsin B precursor | 0.0116 | 0.1906 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.013 | 0.2521 | 0.2521 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.013 | 0.2521 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.009 | 0.0802 | 0.0802 |
Onchocerca volvulus | 0.013 | 0.2521 | 1 | |
Leishmania major | cathepsin L-like protease | 0.013 | 0.2521 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.013 | 0.2521 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.013 | 0.2521 | 0.2521 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.013 | 0.2521 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.013 | 0.2521 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.013 | 0.2521 | 0.2521 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.013 | 0.2521 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0305 | 1 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.0116 | 0.1906 | 0.12 |
Leishmania major | cathepsin L-like protease | 0.013 | 0.2521 | 1 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0095 | 0.1031 | 0.0249 |
Leishmania major | cysteine peptidase A (CPA) | 0.013 | 0.2521 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.013 | 0.2521 | 0.2521 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.013 | 0.2521 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.009 | 0.0802 | 0.0802 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.013 | 0.2521 | 0.1869 |
Echinococcus granulosus | cathepsin b | 0.0305 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0305 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.013 | 0.2521 | 0.2521 |
Echinococcus granulosus | cathepsin b | 0.0305 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.009 | 0.0802 | 0.0802 |
Loa Loa (eye worm) | cysteine protease | 0.013 | 0.2521 | 0.1869 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0305 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.013 | 0.2521 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
pKa | = 6.98 | pKa value of the compound determined | ChEMBL. | 11720863 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.