Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.3 uM | Antitrypanosomal activity against epimastigote form of Trypanosoma cruzi Y infected in monkey LCC-MK2 cells assessed as parasite growth inhibition after 15 hrs by trypan blue staining-based hemocytometric analysis | ChEMBL. | 23811085 |
TGI (functional) | = 9.4 uM | Cytotoxicity against human T47D cells after 48 hrs by SRB assay | ChEMBL. | 23811085 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma cruzi | ChEMBL23 | 23811085 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.