TDR Targets

Basic information

Technical information

TDR Targets ID: 1775474
Name: 2-(3-methoxyphenyl)pyrimidine
MW: 186.21 | Formula: C11H10N2O
H donors: 0 H acceptors: 2 LogP: 1.84 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: COc1cccc(c1)c1ncccn1
InChi: 1S/C11H10N2O/c1-14-10-5-2-4-9(8-10)11-12-6-3-7-13-11/h2-8H,1H3
InChiKey: WKBXGYLBOOBRIK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	CDC-like kinase 4	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma brucei	kinetoplastid kinetochore protein 19	Get druggable targets OG5_126990	All targets in OG5_126990
Plasmodium falciparum	protein serine/threonine kinase-1	Get druggable targets OG5_126990	All targets in OG5_126990
Echinococcus multilocularis	dual specificity protein kinase clk2	Get druggable targets OG5_126990	All targets in OG5_126990
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126990	All targets in OG5_126990
Babesia bovis	protein serine/threonine kinase 1	Get druggable targets OG5_126990	All targets in OG5_126990
Plasmodium berghei	serine/threonine kinase-1, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Plasmodium knowlesi	serine/threonine kinase-1, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Theileria parva	serine/threonine protein kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Schistosoma japonicum	Serine/threonine-protein kinase Doa, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_126990	All targets in OG5_126990
Candida albicans	Serine/threonine protein kinase	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma brucei	kinetoplastid kinetochore protein 10	Get druggable targets OG5_126990	All targets in OG5_126990
Leishmania infantum	protein kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Plasmodium yoelii	protein serine/threonine kinase-1	Get druggable targets OG5_126990	All targets in OG5_126990
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Neospora caninum	hypothetical protein	Get druggable targets OG5_126990	All targets in OG5_126990
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma congolense	kinetoplastid kinetochore protein, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Toxoplasma gondii	cell-cycle-associated protein kinase CLK, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Leishmania braziliensis	protein kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Leishmania major	protein kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Echinococcus multilocularis		Get druggable targets OG5_126990	All targets in OG5_126990
Cryptosporidium hominis	serine/threonine kinase-1	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma brucei gambiense	protein kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Leishmania mexicana	protein kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126990	All targets in OG5_126990
Cryptosporidium parvum	serine/threonine kinase-1	Get druggable targets OG5_126990	All targets in OG5_126990
Candida albicans	Serine/threonine protein kinase	Get druggable targets OG5_126990	All targets in OG5_126990
Giardia lamblia	Kinase, CMGC CLK	Get druggable targets OG5_126990	All targets in OG5_126990
Leishmania infantum	protein kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Leishmania mexicana		Get druggable targets OG5_126990	All targets in OG5_126990
Leishmania major	protein kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126990	All targets in OG5_126990
Echinococcus granulosus	hypothetical protein	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma congolense	kinetoplastid kinetochore protein, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Loa Loa (eye worm)	CMGC/CLK protein kinase	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Schistosoma japonicum	ko:K08823 CDC-like kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma congolense	kinetoplastid kinetochore protein 10, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Echinococcus granulosus	dual specificity protein kinase clk2	Get druggable targets OG5_126990	All targets in OG5_126990
Plasmodium vivax	serine/threonine kinase-1, putative	Get druggable targets OG5_126990	All targets in OG5_126990

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0172	0.3118	0.3128
Brugia malayi	Protein kinase domain containing protein	0.029	0.9968	1
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Schistosoma mansoni	GTPase activating protein	0.0172	0.3118	0.3128
Loa Loa (eye worm)	hypothetical protein	0.029	0.9968	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0172	0.3118	0.3118
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0172	0.3118	0.3118
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Echinococcus granulosus	SH2 motif	0.0172	0.3118	0.3118
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.029	0.9968	1
Echinococcus granulosus	NCK adaptor protein	0.0172	0.3118	0.3118
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.029	0.9968	1
Schistosoma mansoni	tyrosine kinase	0.029	0.9968	1
Schistosoma mansoni	growth factor receptor-bound protein	0.0172	0.3118	0.3128
Onchocerca volvulus		0.029	0.9968	1
Onchocerca volvulus		0.0172	0.3118	0.3128
Echinococcus multilocularis		0.0172	0.3118	0.3128
Echinococcus multilocularis	tensin	0.0172	0.3118	0.3128
Trichomonas vaginalis	CAMK family protein kinase	0.0118	0	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0172	0.3118	0.3128
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0118	0	0.5
Schistosoma mansoni	tensin-related	0.0172	0.3118	0.3128
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.029	0.9968	0.9968
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0172	0.3118	0.3128
Echinococcus granulosus	c src tyrosine kinase	0.029	0.9968	0.9968
Echinococcus multilocularis	tyrosine protein kinase Srms	0.029	0.9968	1
Echinococcus multilocularis	N chimaerin	0.0172	0.3118	0.3128
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0118	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.029	0.9968	1
Onchocerca volvulus		0.029	0.9968	1
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Brugia malayi	Tensin	0.0172	0.3118	0.3128
Loa Loa (eye worm)	hypothetical protein	0.0172	0.3118	0.3128
Trichomonas vaginalis	protein kinase atn1, putative	0.0118	0	0.5
Echinococcus multilocularis	c src tyrosine kinase	0.029	0.9968	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.029	0.9968	0.9968
Schistosoma mansoni	vav2	0.0172	0.3118	0.3128
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0118	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.029	0.9968	1
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0118	0	0.5
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0172	0.3118	0.3128
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.029	0.9968	1
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0172	0.3118	0.3128
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.029	0.9968	0.9968
Loa Loa (eye worm)	SH2 domain-containing protein	0.0172	0.3118	0.3128
Echinococcus granulosus	tyrosine protein kinase ABL1	0.029	0.9968	0.9968
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0172	0.3118	0.3128
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0172	0.3118	0.3128
Trypanosoma brucei	protein kinase, putative	0.0119	0.0032	1
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0172	0.3118	0.3118
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.029	0.9968	1
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0172	0.3118	0.3128
Echinococcus multilocularis	SH2 motif	0.0172	0.3118	0.3128
Brugia malayi	Variant SH3 domain containing protein	0.0172	0.3118	0.3128
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0118	0	0.5
Schistosoma mansoni	tyrosine kinase	0.029	0.9968	1
Brugia malayi	SH2 domain containing protein	0.0172	0.3118	0.3128
Echinococcus granulosus	activin receptor type	0.0119	0.0032	0.0032
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0172	0.3118	0.3128
Echinococcus multilocularis	SH2 motif	0.0172	0.3118	0.3128
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Brugia malayi	hypothetical protein	0.0172	0.3118	0.3128
Schistosoma mansoni	protein kinase	0.0119	0.0032	0.0032
Echinococcus granulosus	tensin	0.0172	0.3118	0.3118
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.029	0.9968	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0173	0.315	0.316
Loa Loa (eye worm)	TK/FER protein kinase	0.029	0.9968	1
Giardia lamblia	Protein 21.1	0.0118	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0118	0	0.5
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0172	0.3118	0.3118
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0172	0.3118	0.3118
Echinococcus multilocularis	tyrosine protein kinase Abl	0.029	0.9968	1
Loa Loa (eye worm)	hypothetical protein	0.0172	0.3118	0.3128
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0172	0.3118	0.3128
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0172	0.3118	0.3118
Onchocerca volvulus		0.029	0.9968	1
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Schistosoma mansoni	growth factor receptor-bound protein	0.0172	0.3118	0.3128
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Schistosoma mansoni	suppressor of cytokine signaling	0.0172	0.3118	0.3128
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Echinococcus multilocularis	activin receptor type	0.0119	0.0032	0.0032
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0172	0.3118	0.3128
Echinococcus granulosus	hypothetical protein	0.0172	0.3118	0.3118
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0118	0	0.5
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.029	0.9968	0.9968
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.029	0.9968	1
Echinococcus multilocularis	signal transduction protein lnk realted	0.0172	0.3118	0.3128
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0172	0.3118	0.3128
Loa Loa (eye worm)	hypothetical protein	0.0172	0.3118	0.3128
Echinococcus multilocularis	SHC transforming protein 3	0.0172	0.3118	0.3128
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0119	0.0032	0.0032
Brugia malayi	hypothetical protein	0.029	0.9968	1
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0119	0.0032	1
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0172	0.3118	0.3118
Trichomonas vaginalis	conserved hypothetical protein	0.0118	0	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0119	0.0032	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0118	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.029	0.9968	1
Echinococcus granulosus	signal transduction protein lnk realted	0.0172	0.3118	0.3118
Schistosoma mansoni	protein kinase	0.0119	0.0032	0.0032
Onchocerca volvulus		0.029	0.9968	1
Trichomonas vaginalis	TK family protein kinase	0.0118	0	0.5
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0172	0.3118	0.3128
Echinococcus granulosus	tyrosine protein kinase Blk	0.029	0.9968	0.9968
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.029	0.9968	1
Schistosoma mansoni	shc transforming protein	0.0172	0.3118	0.3128
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.029	0.9968	1
Loa Loa (eye worm)	SRC-1	0.029	0.9968	1
Echinococcus multilocularis	tyrosine protein kinase Blk	0.029	0.9968	1
Trichomonas vaginalis	conserved hypothetical protein	0.0118	0	0.5
Echinococcus multilocularis	SH2 domain containing protein 7	0.0172	0.3118	0.3128
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.029	0.9968	0.9968
Echinococcus granulosus	expressed conserved protein	0.0172	0.3118	0.3118
Schistosoma mansoni	tensin-related	0.0172	0.3118	0.3128
Brugia malayi	SH2 domain containing protein	0.0172	0.3118	0.3128
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.029	0.9968	1
Giardia lamblia	Kinase, NEK	0.0118	0	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0118	0	0.5
Brugia malayi	SH2 domain containing protein	0.0172	0.3118	0.3128
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0172	0.3118	0.3128
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.029	0.9968	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0172	0.3118	0.3128
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Loa Loa (eye worm)	STAT protein	0.0172	0.3118	0.3128
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Brugia malayi	SH2 domain containing protein	0.0172	0.3118	0.3128
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Schistosoma mansoni	hypothetical protein	0.0172	0.3118	0.3128
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0172	0.3118	0.3128
Entamoeba histolytica	protein kinase, putative	0.0173	0.315	0.316
Loa Loa (eye worm)	TK/FER protein kinase	0.029	0.9968	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0172	0.3118	0.3128
Loa Loa (eye worm)	hypothetical protein	0.0172	0.3118	0.3128
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Onchocerca volvulus		0.029	0.9968	1
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Schistosoma mansoni	hypothetical protein	0.0172	0.3118	0.3128
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.029	0.9968	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0172	0.3118	0.3118
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0172	0.3118	0.3128
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0118	0	0.5
Brugia malayi	RhoGAP domain containing protein	0.0172	0.3118	0.3128
Brugia malayi	protein-tyrosine kinase	0.029	0.9968	1
Loa Loa (eye worm)	TK/FER protein kinase	0.029	0.9968	1
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0172	0.3118	0.3128
Plasmodium vivax	protein kinase, putative	0.0118	0	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.029	0.9968	0.9968
Echinococcus granulosus	tyrosine protein kinase Fyn	0.029	0.9968	0.9968
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0172	0.3118	0.3128
Onchocerca volvulus		0.0172	0.3118	0.3128
Brugia malayi	Variant SH3 domain containing protein	0.0172	0.3118	0.3128
Schistosoma mansoni	suppressor of cytokine signaling	0.0172	0.3118	0.3128
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0172	0.3118	0.3128
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0172	0.3118	0.3128
Schistosoma mansoni	tyrosine kinase	0.029	0.9968	1
Schistosoma mansoni	signal transduction protein lnk-related	0.0172	0.3118	0.3128
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Echinococcus granulosus	N chimaerin	0.0172	0.3118	0.3118
Loa Loa (eye worm)	SH2 domain-containing protein	0.0172	0.3118	0.3128
Echinococcus granulosus	growth factor receptor bound protein 2	0.0172	0.3118	0.3118
Echinococcus granulosus	tyrosine protein kinase shark	0.029	0.9968	0.9968
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Loa Loa (eye worm)	TK protein kinase	0.029	0.9968	1
Brugia malayi	SH2 domain containing protein	0.0172	0.3118	0.3128
Brugia malayi	Variant SH3 domain containing protein	0.0172	0.3118	0.3128
Echinococcus multilocularis	tyrosine kinase	0.029	0.9968	1
Echinococcus multilocularis	SH2 motif	0.0172	0.3118	0.3128
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Echinococcus granulosus	SH2 domain containing protein 7	0.0172	0.3118	0.3118
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.029	0.9968	1
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0172	0.3118	0.3128
Schistosoma mansoni	tensin	0.0172	0.3118	0.3128
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Brugia malayi	SH2 domain containing protein	0.0172	0.3118	0.3128
Onchocerca volvulus		0.0172	0.3118	0.3128
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.029	0.9968	1
Onchocerca volvulus		0.029	0.9968	1
Echinococcus multilocularis	tensin	0.0172	0.3118	0.3128
Loa Loa (eye worm)	TK/FER protein kinase	0.029	0.9968	1
Schistosoma mansoni	tensin	0.0172	0.3118	0.3128
Entamoeba histolytica	SH2 domain containing protein	0.0172	0.3118	0.3128
Loa Loa (eye worm)	SH2 domain-containing protein	0.0172	0.3118	0.3128
Schistosoma mansoni	tyrosine kinase	0.029	0.9968	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.029	0.9968	1
Loa Loa (eye worm)	hypothetical protein	0.0172	0.3118	0.3128
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0172	0.3118	0.3128
Loa Loa (eye worm)	TK/ABL protein kinase	0.029	0.9968	1
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.029	0.9968	1
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0172	0.3118	0.3128
Trichomonas vaginalis	conserved hypothetical protein	0.0118	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0172	0.3118	0.3128
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0119	0.0032	1
Trichomonas vaginalis	STE family protein kinase	0.0118	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.029	0.9968	1
Onchocerca volvulus		0.0172	0.3118	0.3128
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Echinococcus granulosus	SHC transforming protein 3	0.0172	0.3118	0.3118
Plasmodium falciparum	protein kinase, putative	0.0119	0.0032	1
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.029	0.9968	1
Loa Loa (eye worm)	hypothetical protein	0.0172	0.3118	0.3128
Brugia malayi	Protein kinase domain containing protein	0.029	0.9968	1
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0172	0.3118	0.3128
Schistosoma mansoni	protein kinase	0.0119	0.0032	0.0032
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.029	0.9968	1
Giardia lamblia	Kinase	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Schistosoma mansoni	adapter molecule crk	0.0172	0.3118	0.3128
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Schistosoma mansoni	tyrosine kinase	0.029	0.9968	1
Loa Loa (eye worm)	hypothetical protein	0.0172	0.3118	0.3128
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0172	0.3118	0.3128
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Leishmania major	protein kinase, putative	0.0119	0.0032	1
Schistosoma mansoni	tyrosine kinase	0.029	0.9968	1
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Brugia malayi	SH2 domain containing protein	0.0172	0.3118	0.3128
Echinococcus multilocularis	NCK adaptor protein	0.0172	0.3118	0.3128
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0118	0	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.029	0.9968	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0172	0.3118	0.3128
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0172	0.3118	0.3128
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0172	0.3118	0.3128
Echinococcus multilocularis	tyrosine protein kinase shark	0.029	0.9968	1
Brugia malayi	SRC-1	0.029	0.9968	1
Loa Loa (eye worm)	hypothetical protein	0.0172	0.3118	0.3128
Echinococcus granulosus	tyrosine kinase	0.029	0.9968	0.9968
Trichomonas vaginalis	conserved hypothetical protein	0.0118	0	0.5
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0119	0.0032	0.0032
Echinococcus granulosus	tyrosine protein kinase Fyn	0.029	0.9968	0.9968
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.029	0.9968	1
Onchocerca volvulus		0.0172	0.3118	0.3128
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0172	0.3118	0.3128
Loa Loa (eye worm)	hypothetical protein	0.0172	0.3118	0.3128
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Echinococcus granulosus	tyrosine kinase	0.029	0.9968	0.9968
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Echinococcus granulosus	tyrosine protein kinase Srms	0.029	0.9968	0.9968
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Echinococcus granulosus	SH2 motif	0.0172	0.3118	0.3118
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.029	0.9968	0.9968
Entamoeba histolytica	protein kinase domain containing protein	0.0119	0.0032	0.0032
Brugia malayi	SH2 domain containing protein	0.029	0.9968	1
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0118	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0172	0.3118	0.3128
Echinococcus granulosus	tyrosine protein kinase Src64B	0.029	0.9968	0.9968
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0172	0.3118	0.3118
Giardia lamblia	Kinase, NEK	0.0118	0	0.5
Schistosoma mansoni	tensin	0.0172	0.3118	0.3128
Schistosoma mansoni	SH2A	0.0172	0.3118	0.3128
Brugia malayi	Tyrosine-protein kinase abl-1	0.029	0.9968	1
Onchocerca volvulus		0.0172	0.3118	0.3128
Brugia malayi	SH2 domain containing protein	0.029	0.9968	1
Brugia malayi	Protein kinase domain containing protein	0.029	0.9968	1
Schistosoma mansoni	nck2/grb4	0.0172	0.3118	0.3128
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0119	0.0032	1
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0172	0.3118	0.3128
Brugia malayi	Sex muscle abnormal protein 5	0.0172	0.3118	0.3128

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 16.4 uM	Inhibition of CLK4 (unknown origin) by bioluminescence assay	ChEMBL.	23642479
IC50 (binding)	= 26 uM	Inhibition of DYRK1A (unknown origin) by bioluminescence assay	ChEMBL.	23642479

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2392355

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1775474