Detailed information for compound 1776461

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 338.361 | Formula: C18H18N4O3
  • H donors: 1 H acceptors: 4 LogP: 1.28 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#C[C@@H]1CCCN1C(=O)CNC(=O)c1ccnc2c1cc(OC)cc2
  • InChi: 1S/C18H18N4O3/c1-25-13-4-5-16-15(9-13)14(6-7-20-16)18(24)21-11-17(23)22-8-2-3-12(22)10-19/h4-7,9,12H,2-3,8,11H2,1H3,(H,21,24)/t12-/m0/s1
  • InChiKey: YPWQFVMQCFSLCP-LBPRGKRZSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens prolyl endopeptidase Starlite/ChEMBL References
Mus musculus fibroblast activation protein Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi prolyl oligopeptidase family protein Get druggable targets OG5_128614 All targets in OG5_128614
Leishmania mexicana prolyl oligopeptidase, putative Get druggable targets OG5_129295 All targets in OG5_129295
Schistosoma mansoni prolyl oligopeptidase (S09 family) Get druggable targets OG5_129295 All targets in OG5_129295
Candida albicans dipeptidyl aminopeptidase B Get druggable targets OG5_128614 All targets in OG5_128614
Schistosoma mansoni prolyl oligopeptidase (S09 family) Get druggable targets OG5_129295 All targets in OG5_129295
Trypanosoma brucei gambiense prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative Get druggable targets OG5_129295 All targets in OG5_129295
Schistosoma japonicum Prolyl endopeptidase, putative Get druggable targets OG5_129295 All targets in OG5_129295
Echinococcus granulosus prolyl endopeptidase Get druggable targets OG5_129295 All targets in OG5_129295
Onchocerca volvulus Prolyl endopeptidase homolog Get druggable targets OG5_129295 All targets in OG5_129295
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein Get druggable targets OG5_128614 All targets in OG5_128614
Toxoplasma gondii prolyl endopeptidase Get druggable targets OG5_129295 All targets in OG5_129295
Trypanosoma brucei prolyl endopeptidase Get druggable targets OG5_129295 All targets in OG5_129295
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative Get druggable targets OG5_129295 All targets in OG5_129295
Loa Loa (eye worm) prolyl oligopeptidase Get druggable targets OG5_128614 All targets in OG5_128614
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) Get druggable targets OG5_128614 All targets in OG5_128614
Schistosoma japonicum ko:K01278 dipeptidyl-peptidase 4, putative Get druggable targets OG5_128614 All targets in OG5_128614
Leishmania donovani prolyl endopeptidase Get druggable targets OG5_129295 All targets in OG5_129295
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) Get druggable targets OG5_129295 All targets in OG5_129295
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129295 All targets in OG5_129295
Trypanosoma congolense prolyl endopeptidase Get druggable targets OG5_129295 All targets in OG5_129295
Leishmania infantum prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative Get druggable targets OG5_129295 All targets in OG5_129295
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog Get druggable targets OG5_128614 All targets in OG5_128614
Neospora caninum Prolyl oligopeptidase (EC 3.4.21.26) (Precursor), related Get druggable targets OG5_129295 All targets in OG5_129295
Trypanosoma cruzi prolyl endopeptidase Get druggable targets OG5_129295 All targets in OG5_129295
Schistosoma japonicum ko:K01322 prolyl oligopeptidase [EC3.4.21.26], putative Get druggable targets OG5_129295 All targets in OG5_129295
Brugia malayi prolyl oligopeptidase family protein Get druggable targets OG5_129295 All targets in OG5_129295
Echinococcus multilocularis prolyl endopeptidase Get druggable targets OG5_129295 All targets in OG5_129295
Candida albicans dipeptidyl aminopeptidase B Get druggable targets OG5_128614 All targets in OG5_128614
Echinococcus granulosus dipeptidyl aminopeptidaseprotein Get druggable targets OG5_128614 All targets in OG5_128614
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei oligopeptidase b prolyl endopeptidase 710 aa 630 aa 27.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis rhodopsin orphan GPCR 0.0089 0.0141 0.0141
Schistosoma mansoni neuropeptide receptor 0.0089 0.0141 0.0141
Brugia malayi hypothetical protein 0.0089 0.0141 0.0141
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0089 0.0141 0.0141
Echinococcus multilocularis dro:myosuppressin receptor 0.0089 0.0141 0.0141
Brugia malayi hypothetical protein 0.0089 0.0141 0.0141
Schistosoma mansoni neuropeptide receptor 0.0089 0.0141 0.0141
Echinococcus multilocularis rhodopsin orphan GPCR 0.0089 0.0141 0.0141
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0089 0.0141 0.0141
Echinococcus granulosus biogenic amine 5HT receptor 0.0089 0.0141 0.0141
Echinococcus granulosus peptide allatostatin:somatostatin 0.0089 0.0141 0.0141
Echinococcus multilocularis neuropeptide receptor A26 0.0089 0.0141 0.0141
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0089 0.0141 0.0141
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0089 0.0141 0.0141
Echinococcus granulosus somatostatin receptor 0.0089 0.0141 0.0141
Brugia malayi hypothetical protein 0.0089 0.0141 0.0141
Brugia malayi putative neuropeptide receptor 0.0089 0.0141 0.0141
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0089 0.0141 0.0141
Echinococcus granulosus orexin receptor type 2 0.0089 0.0141 0.0141
Schistosoma mansoni hypothetical protein 0.0089 0.0141 0.0141
Echinococcus multilocularis g protein coupled receptor 0.0089 0.0141 0.0141
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0142 0.3931 0.5
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0175 0.632 0.632
Echinococcus multilocularis neuropeptides capa receptor 0.0089 0.0141 0.0141
Brugia malayi G protein-coupled receptor 0.0089 0.0141 0.0141
Schistosoma mansoni neuropeptide receptor 0.0089 0.0141 0.0141
Echinococcus granulosus rhodopsin orphan GPCR 0.0089 0.0141 0.0141
Schistosoma mansoni amine GPCR 0.0089 0.0141 0.0141
Trypanosoma cruzi prolyl endopeptidase 0.0175 0.632 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0089 0.0141 0.0141
Echinococcus granulosus dro:myosuppressin receptor 0.0089 0.0141 0.0141
Brugia malayi hypothetical protein 0.0089 0.0141 0.0141
Schistosoma mansoni amine GPCR 0.0089 0.0141 0.0141
Echinococcus multilocularis neuropeptide FF receptor 2 0.0089 0.0141 0.0141
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0089 0.0141 0.0141
Brugia malayi G protein-coupled receptor F59B2.13 0.0089 0.0141 0.0141
Schistosoma mansoni neuropeptide F-like receptor 0.0089 0.0141 0.0141
Brugia malayi AKH receptor 0.0089 0.0141 0.0141
Brugia malayi larval opioid receptor 0.0089 0.0141 0.0141
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0089 0.0141 0.0141
Echinococcus multilocularis neuropeptide receptor 0.0089 0.0141 0.0141
Brugia malayi hypothetical protein 0.0089 0.0141 0.0141
Brugia malayi neuropeptide F receptor 0.0089 0.0141 0.0141
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0089 0.0141 0.0141
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0089 0.0141 0.0141
Echinococcus granulosus fmrfamide receptor 0.0089 0.0141 0.0141
Echinococcus multilocularis neuropeptide Y receptor 0.0089 0.0141 0.0141
Brugia malayi hypothetical protein 0.0089 0.0141 0.0141
Schistosoma mansoni neuropeptide f receptor 76f 0.0089 0.0141 0.0141
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0089 0.0141 0.0141
Echinococcus granulosus neuropeptide s receptor 0.0089 0.0141 0.0141
Echinococcus multilocularis neuropeptide Y receptor 0.0089 0.0141 0.0141
Schistosoma mansoni amine GPCR 0.0089 0.0141 0.0141
Brugia malayi sulfakinin receptor protein 0.0089 0.0141 0.0141
Brugia malayi GnHR receptor homolog 0.0089 0.0141 0.0141
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0089 0.0141 0.0141
Echinococcus multilocularis rhodopsin orphan GPCR 0.0089 0.0141 0.0141
Schistosoma mansoni hypothetical protein 0.0089 0.0141 0.0141
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0089 0.0141 0.0141
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0089 0.0141 0.0141
Brugia malayi prolyl oligopeptidase family protein 0.0175 0.632 0.632
Echinococcus multilocularis G protein coupled receptor 139 0.0089 0.0141 0.0141
Echinococcus multilocularis allatostatin A receptor 0.0089 0.0141 0.0141
Echinococcus granulosus rhodopsin orphan GPCR 0.0089 0.0141 0.0141
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0175 0.632 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0089 0.0141 0.0141
Brugia malayi Dopamine receptor protein 2 0.0089 0.0141 0.0141
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0089 0.0141 0.0141
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0089 0.0141 0.0141
Brugia malayi Dopamine receptor 0.0089 0.0141 0.0141
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0089 0.0141 0.0141
Echinococcus granulosus rhodopsin orphan GPCR 0.0089 0.0141 0.0141
Echinococcus multilocularis g protein coupled receptor 0.0089 0.0141 0.0141
Schistosoma mansoni biogenic amine (5HT) receptor 0.0089 0.0141 0.0141
Schistosoma mansoni myosin xvIII 0.0089 0.0141 0.0141
Brugia malayi hypothetical protein 0.0089 0.0141 0.0141
Trypanosoma brucei prolyl endopeptidase 0.0175 0.632 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0089 0.0141 0.0141
Echinococcus multilocularis fmrfamide receptor 0.0089 0.0141 0.0141
Echinococcus granulosus tm gpcr rhodopsin 0.0089 0.0141 0.0141
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0089 0.0141 0.0141
Echinococcus granulosus G protein coupled receptor 139 0.0089 0.0141 0.0141
Echinococcus multilocularis sex peptide receptor 0.0089 0.0141 0.0141
Brugia malayi follicle stimulating hormone receptor 0.0089 0.0141 0.0141
Echinococcus granulosus sex peptide receptor 0.0089 0.0141 0.0141
Echinococcus granulosus 7tm_1 domain containing protein 0.0089 0.0141 0.0141
Brugia malayi Dopamine receptor protein 1 0.0089 0.0141 0.0141
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0089 0.0141 0.0141
Echinococcus granulosus g protein coupled receptor 0.0089 0.0141 0.0141
Schistosoma mansoni amine GPCR 0.0089 0.0141 0.0141
Brugia malayi Melatonin receptor type 1A 0.0089 0.0141 0.0141
Echinococcus granulosus prolyl endopeptidase 0.0175 0.632 0.632
Brugia malayi hypothetical protein 0.0089 0.0141 0.0141
Schistosoma mansoni neuropeptide F-like receptor 0.0089 0.0141 0.0141
Schistosoma mansoni amine GPCR 0.0089 0.0141 0.0141
Brugia malayi hypothetical protein 0.0089 0.0141 0.0141
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0089 0.0141 0.0141
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0089 0.0141 0.0141
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0089 0.0141 0.0141
Echinococcus granulosus g-protein coupled receptor 0.0089 0.0141 0.0141
Brugia malayi G-protein coupled receptor 0.0089 0.0141 0.0141
Echinococcus granulosus alpha 1A adrenergic receptor 0.0089 0.0141 0.0141
Loa Loa (eye worm) hypothetical protein 0.0175 0.632 0.6267
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0089 0.0141 0.0141
Echinococcus granulosus neuropeptide Y receptor 0.0089 0.0141 0.0141
Echinococcus multilocularis neuropeptide s receptor 0.0089 0.0141 0.0141
Echinococcus granulosus tm gpcr rhodopsin 0.0089 0.0141 0.0141
Schistosoma mansoni neuropeptide receptor 0.0089 0.0141 0.0141
Echinococcus multilocularis somatostatin receptor 0.0089 0.0141 0.0141
Brugia malayi Serotonin receptor 0.0089 0.0141 0.0141
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0089 0.0141 0.0141
Schistosoma mansoni opsin-like receptor 0.0089 0.0141 0.0141
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0089 0.0141 0.0141
Echinococcus multilocularis rhodopsin orphan GPCR 0.0089 0.0141 0.0141
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0089 0.0141 0.0141
Schistosoma mansoni adenoreceptor 0.0089 0.0141 0.0141
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0089 0.0141 0.0141
Echinococcus granulosus biogenic amine 5HT receptor 0.0089 0.0141 0.0141
Echinococcus granulosus rhodopsin orphan GPCR 0.0089 0.0141 0.0141
Schistosoma mansoni biogenic amine receptor 0.0089 0.0141 0.0141
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0089 0.0141 0.0141
Onchocerca volvulus Prolyl endopeptidase homolog 0.0175 0.632 0.6267
Schistosoma mansoni growth hormone secretagogue receptor 0.0089 0.0141 0.0141
Brugia malayi G-protein coupled receptor 0.0089 0.0141 0.0141
Echinococcus multilocularis fmrfamide receptor 0.0089 0.0141 0.0141
Echinococcus multilocularis prolyl endopeptidase 0.0175 0.632 0.632
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0089 0.0141 0.0141
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0089 0.0141 0.0141
Loa Loa (eye worm) prolyl oligopeptidase 0.0226 1 1
Toxoplasma gondii prolyl endopeptidase 0.0175 0.632 1
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0226 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0089 0.0141 0.0141
Echinococcus granulosus neuropeptides capa receptor 0.0089 0.0141 0.0141
Echinococcus granulosus hypothetical protein 0.0089 0.0141 0.0141
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0089 0.0141 0.0141
Echinococcus granulosus tachykinin peptides receptor 99D 0.0089 0.0141 0.0141
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0226 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.0089 0.0141 0.0141
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0089 0.0141 0.0141
Echinococcus multilocularis neuropeptides capa receptor 0.0089 0.0141 0.0141
Echinococcus multilocularis serotonin receptor 0.0089 0.0141 0.0141
Schistosoma mansoni histamine h1 receptor 0.0089 0.0141 0.0141
Echinococcus granulosus neuropeptide receptor A26 0.0089 0.0141 0.0141
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0089 0.0141 0.0141
Echinococcus multilocularis g protein coupled receptor 0.0089 0.0141 0.0141
Echinococcus multilocularis neuropeptide receptor 0.0089 0.0141 0.0141
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0226 1 1
Echinococcus granulosus serotonin receptor 0.0089 0.0141 0.0141
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0089 0.0141 0.0141
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0089 0.0141 0.0141
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0089 0.0141 0.0141
Schistosoma mansoni biogenic amine receptor 0.0089 0.0141 0.0141
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0089 0.0141 0.0141
Echinococcus multilocularis orexin receptor type 2 0.0089 0.0141 0.0141
Echinococcus granulosus 7TM GPCR rhodopsin 0.0089 0.0141 0.0141
Brugia malayi putative neuropeptide receptor NPR1 0.0089 0.0141 0.0141
Echinococcus granulosus neuropeptide Y receptor 0.0089 0.0141 0.0141
Schistosoma mansoni biogenic amine receptor 0.0089 0.0141 0.0141
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0089 0.0141 0.0141
Brugia malayi Serotonin receptor 0.0089 0.0141 0.0141
Echinococcus granulosus rhodopsin orphan GPCR 0.0089 0.0141 0.0141
Echinococcus granulosus g protein coupled receptor 0.0089 0.0141 0.0141
Schistosoma mansoni opsin-like receptor 0.0089 0.0141 0.0141
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0089 0.0141 0.0141
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0089 0.0141 0.0141
Echinococcus multilocularis rhodopsin orphan GPCR 0.0089 0.0141 0.0141
Schistosoma mansoni hypothetical protein 0.0089 0.0141 0.0141
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0089 0.0141 0.0141
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0089 0.0141 0.0141
Echinococcus multilocularis serotonin receptor 0.0089 0.0141 0.0141
Echinococcus multilocularis rhodopsin orphan GPCR 0.0089 0.0141 0.0141
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0089 0.0141 0.0141
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0089 0.0141 0.0141
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0089 0.0141 0.0141
Schistosoma mansoni alpha-1 adrenergic receptor 0.0089 0.0141 0.0141
Brugia malayi RE15519p 0.0089 0.0141 0.0141
Brugia malayi neuropeptide F receptor 0.0089 0.0141 0.0141
Brugia malayi ORL1-like opioid receptor 0.0089 0.0141 0.0141
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0175 0.632 0.632
Echinococcus multilocularis g-protein coupled receptor 0.0089 0.0141 0.0141
Echinococcus granulosus rhodopsin orphan GPCR 0.0089 0.0141 0.0141
Brugia malayi hypothetical protein 0.0089 0.0141 0.0141
Echinococcus granulosus neuropeptide receptor 0.0089 0.0141 0.0141
Echinococcus granulosus neuropeptide receptor 0.0089 0.0141 0.0141
Echinococcus granulosus neuropeptides capa receptor 0.0089 0.0141 0.0141
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0089 0.0141 0.0141
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0226 1 1
Schistosoma mansoni opsin-like receptor 0.0089 0.0141 0.0141
Echinococcus granulosus allatostatin A receptor 0.0089 0.0141 0.0141
Echinococcus multilocularis rhodopsin orphan GPCR 0.0089 0.0141 0.0141
Echinococcus granulosus neuropeptide FF receptor 2 0.0089 0.0141 0.0141
Schistosoma mansoni biogenic amine (5HT) receptor 0.0089 0.0141 0.0141
Echinococcus granulosus g protein coupled receptor 0.0089 0.0141 0.0141
Schistosoma mansoni hypothetical protein 0.0089 0.0141 0.0141
Echinococcus granulosus rhodopsin orphan GPCR 0.0089 0.0141 0.0141
Echinococcus multilocularis G-protein coupled receptor, putative 0.0089 0.0141 0.0141

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 9.2 nM Enzymatic Assay BINDINGDB. No reference
IC50 (binding) = 6100 nM Enzymatic Assay BINDINGDB. No reference
IC50 (binding) > 100000 nM Enzymatic Assay BINDINGDB. No reference
IC50 (binding) > 100000 nM Enzymatic Assay BINDINGDB. No reference
IC50 (binding) > 100000 nM Enzymatic Assay BINDINGDB. No reference
IC50 (binding) = 0.0092 uM Inhibition of mouse recombinant FAP expressed in HEK293 cells using Ala-Pro-p-nitroanilide as substrate incubated for 15 mins prior to substrate addition ChEMBL. 24900696
IC50 (binding) = 6.1 uM Inhibition of human recombinant PREP expressed in Escherichia coli using Z-Gly-Pro-p-nitroanilide as substrate incubated for 15 mins prior to substrate addition ChEMBL. 24900696
IC50 (binding) > 100 uM Inhibition of DPP2 in human seminal plasma using Lys-Ala-p-nitroanilide as substrate incubated for 15 mins prior to substrate addition ChEMBL. 24900696
IC50 (binding) > 100 uM Inhibition of DPP4 in human seminal plasma using Gly-Pro-p-nitroanilide as substrate incubated for 15 mins prior to substrate addition ChEMBL. 24900696

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.