Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | fibroblast activation protein | Starlite/ChEMBL | References |
Homo sapiens | prolyl endopeptidase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | oligopeptidase b | prolyl endopeptidase | 710 aa | 630 aa | 27.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0226 | 1 | 1 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0175 | 0.6507 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0226 | 1 | 1 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0079 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0079 | 0 | 0.5 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0226 | 1 | 1 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0087 | 0.051 | 0.0784 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0175 | 0.6507 | 0.632 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0175 | 0.6507 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0175 | 0.6507 | 0.632 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0087 | 0.051 | 0.0784 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0175 | 0.6507 | 0.632 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0142 | 0.4241 | 1 |
Toxoplasma gondii | prolyl endopeptidase | 0.0175 | 0.6507 | 1 |
Trypanosoma brucei | prolyl endopeptidase | 0.0175 | 0.6507 | 1 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0087 | 0.051 | 0.0784 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0087 | 0.051 | 0.0784 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0087 | 0.051 | 0.0784 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0226 | 1 | 1 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0175 | 0.6507 | 0.632 |
Echinococcus granulosus | prolyl endopeptidase | 0.0175 | 0.6507 | 0.632 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0226 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7.1 nM | Enzymatic Assay | BINDINGDB. | No reference |
IC50 (binding) | = 1400 nM | Enzymatic Assay | BINDINGDB. | No reference |
IC50 (binding) | > 100000 nM | Enzymatic Assay | BINDINGDB. | No reference |
IC50 (binding) | > 100000 nM | Enzymatic Assay | BINDINGDB. | No reference |
IC50 (binding) | > 100000 nM | Enzymatic Assay | BINDINGDB. | No reference |
IC50 (binding) | = 0.0071 uM | Inhibition of mouse recombinant FAP expressed in HEK293 cells using Ala-Pro-p-nitroanilide as substrate incubated for 15 mins prior to substrate addition | ChEMBL. | 24900696 |
IC50 (binding) | = 1.4 uM | Inhibition of human recombinant PREP expressed in Escherichia coli using Z-Gly-Pro-p-nitroanilide as substrate incubated for 15 mins prior to substrate addition | ChEMBL. | 24900696 |
IC50 (binding) | > 100 uM | Inhibition of DPP2 in human seminal plasma using Lys-Ala-p-nitroanilide as substrate incubated for 15 mins prior to substrate addition | ChEMBL. | 24900696 |
IC50 (binding) | > 100 uM | Inhibition of DPP4 in human seminal plasma using Gly-Pro-p-nitroanilide as substrate incubated for 15 mins prior to substrate addition | ChEMBL. | 24900696 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.