Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Hormone-sensitive lipase | Starlite/ChEMBL | References |
Homo sapiens | lipase, hormone-sensitive | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0896 | 0.0684 | 0.0684 |
Mycobacterium leprae | PROBABLE CONSERVED LIPOPROTEIN LPQF | 0.1383 | 0.154 | 1 |
Schistosoma mansoni | solute carrier family 33 (acetyl-CoA transporter | 0.6203 | 1 | 1 |
Mycobacterium ulcerans | class a beta-lactamase, BlaC | 0.2882 | 0.417 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0896 | 0.0684 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0896 | 0.0684 | 0.0684 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.5725 | 0.916 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0896 | 0.0684 | 0.0684 |
Loa Loa (eye worm) | hypothetical protein | 0.0896 | 0.0684 | 0.0684 |
Loa Loa (eye worm) | hypothetical protein | 0.0896 | 0.0684 | 0.0684 |
Mycobacterium ulcerans | lipoprotein LpqF | 0.1383 | 0.154 | 0.2454 |
Toxoplasma gondii | Acetyl-coenzyme A transporter, putative | 0.6203 | 1 | 1 |
Trypanosoma brucei | beta lactamase | 0.1383 | 0.154 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0896 | 0.0684 | 0.0684 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0896 | 0.0684 | 0.0684 |
Loa Loa (eye worm) | hypothetical protein | 0.0896 | 0.0684 | 0.0684 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0896 | 0.0684 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0896 | 0.0684 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0896 | 0.0684 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0896 | 0.0684 | 0.0684 |
Plasmodium vivax | hypothetical protein, conserved | 0.0896 | 0.0684 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.6203 | 1 | 1 |
Onchocerca volvulus | 0.0896 | 0.0684 | 0.5 | |
Schistosoma mansoni | solute carrier family 33 (acetyl-CoA transporter | 0.2306 | 0.3159 | 0.3159 |
Loa Loa (eye worm) | beta-lactamase | 0.0896 | 0.0684 | 0.0684 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0896 | 0.0684 | 0.5 |
Mycobacterium tuberculosis | Probable conserved lipoprotein LpqF | 0.1383 | 0.154 | 0.1009 |
Leishmania major | hypothetical protein, conserved | 0.0896 | 0.0684 | 0.5 |
Echinococcus granulosus | solute carrier family 33 | 0.6203 | 1 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0896 | 0.0684 | 0.5 |
Plasmodium falciparum | acetyl-CoA transporter, putative | 0.6203 | 1 | 0.5 |
Onchocerca volvulus | 0.0896 | 0.0684 | 0.5 | |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0896 | 0.0684 | 0.5 |
Echinococcus multilocularis | solute carrier family 33 | 0.6203 | 1 | 1 |
Mycobacterium tuberculosis | Class a beta-lactamase BlaC | 0.2882 | 0.417 | 0.4113 |
Onchocerca volvulus | 0.0896 | 0.0684 | 0.5 | |
Brugia malayi | Protein C21B10.09 in chromosome II | 0.6203 | 1 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0896 | 0.0684 | 0.0684 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0896 | 0.0684 | 0.0684 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0896 | 0.0684 | 0.5 |
Schistosoma mansoni | solute carrier family 33 (acetyl-CoA transporter | 0.6203 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 11 nM | Inhibition of human recombinant hormone sensitive lipase (HSL) | ChEMBL. | 15149665 |
IC50 (binding) | = 11 nM | Inhibition of human recombinant hormone sensitive lipase (HSL) | ChEMBL. | 15149665 |
IC50 (binding) | = 11 nM | Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assay | ChEMBL. | 18808096 |
IC50 (functional) | = 98 nM | Inhibition of forskolin-stimulated lipolysis in differentiated 3T3-L1 cells | ChEMBL. | 15149665 |
IC50 (functional) | = 98 nM | Inhibition of forskolin-stimulated lipolysis in differentiated 3T3-L1 cells | ChEMBL. | 15149665 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.