Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutamate receptor, metabotropic 5 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0279 | 0.0684 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0905 | 0.2482 | 0.2465 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0055 | 0.0033 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.1184 | 0.3284 | 1 |
Schistosoma mansoni | acylaminoacyl-peptidase (S09 family) | 0.0279 | 0.0684 | 0.0684 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0279 | 0.0684 | 0.5 |
Echinococcus granulosus | acylamino acid releasing enzyme | 0.0279 | 0.0684 | 0.0684 |
Plasmodium falciparum | peptidase, putative | 0.0279 | 0.0684 | 0.5 |
Trichomonas vaginalis | Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase | 0.0279 | 0.0684 | 0.5 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.3523 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0279 | 0.0684 | 0.0663 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0279 | 0.0684 | 0.5 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.1184 | 0.3284 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0279 | 0.0684 | 0.5 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.1184 | 0.3284 | 1 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.3523 | 1 | 1 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.3523 | 1 | 1 |
Echinococcus granulosus | prolyl endopeptidase | 0.0279 | 0.0684 | 0.0684 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0279 | 0.0684 | 0.5 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0279 | 0.0684 | 0.5 |
Brugia malayi | prolyl oligopeptidase family protein | 0.1184 | 0.3284 | 0.3278 |
Plasmodium vivax | hypothetical protein, conserved | 0.0279 | 0.0684 | 0.5 |
Mycobacterium tuberculosis | Probable protease II PtrBb [second part] (oligopeptidase B) | 0.0279 | 0.0684 | 0.5 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.1184 | 0.3284 | 0.3284 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0279 | 0.0684 | 0.0675 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.3523 | 1 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0279 | 0.0684 | 0.0684 |
Loa Loa (eye worm) | hypothetical protein | 0.0279 | 0.0684 | 0.0663 |
Brugia malayi | hypothetical protein | 0.0905 | 0.2482 | 0.2475 |
Loa Loa (eye worm) | hypothetical protein | 0.0279 | 0.0684 | 0.0663 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0279 | 0.0684 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0056 | 0.0042 | 0.0042 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0279 | 0.0684 | 0.5 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0279 | 0.0684 | 0.5 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.006 | 0.0055 | 0.0055 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.1184 | 0.3284 | 0.3284 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0279 | 0.0684 | 0.5 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0279 | 0.0684 | 0.0684 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.1184 | 0.3284 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.3523 | 1 | 1 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.1184 | 0.3284 | 1 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0049 | 0.0023 | 0.0013 |
Echinococcus multilocularis | acylamino acid releasing enzyme | 0.0279 | 0.0684 | 0.0684 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0279 | 0.0684 | 0.0675 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0279 | 0.0684 | 0.5 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.006 | 0.0055 | 0.0055 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0279 | 0.0684 | 0.5 |
Mycobacterium tuberculosis | Probable peptidase | 0.0279 | 0.0684 | 0.5 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0279 | 0.0684 | 0.0675 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.1184 | 0.3284 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0279 | 0.0684 | 0.0684 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.1184 | 0.3284 | 0.3284 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0279 | 0.0684 | 0.0663 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0279 | 0.0684 | 0.0684 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 11 nM | Positive allosteric modulation of human mGlu5 receptor expressed in HEK293 cells assessed as potentiation of L-glutamate-induced activity after 1 hr by FLIPR assay | ChEMBL. | 23770058 |
Emax (binding) | = 170 % | Positive allosteric modulation of human mGlu5 receptor expressed in HEK293 cells assessed as potentiation of L-glutamate-induced activity after 1 hr by FLIPR assay relative to control | ChEMBL. | 23770058 |
IC50 (binding) | > 10000 nM | Negative allosteric modulation of human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-glutamate-induced activity after 1 hr by FLIPR assay | ChEMBL. | 23770058 |
Inhibition (binding) | = 12 % | Negative allosteric modulation of human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-glutamate-induced activity after 1 hr by FLIPR assay relative to control | ChEMBL. | 23770058 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.