Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | integrin beta-2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma mansoni | integrin beta subunit | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | Integrin beta-3 precursor, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | Integrin beta-PS precursor, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Echinococcus granulosus | integrin beta 2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | ko:K06464 integrin beta 2, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Echinococcus multilocularis | integrin beta 2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Brugia malayi | Integrin beta pat-3 precursor | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 0.0176 | 0.02 |
Echinococcus granulosus | acetylcholinesterase | 0.0632 | 0.8824 | 0.8824 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0632 | 0.8824 | 0.9076 |
Brugia malayi | MH2 domain containing protein | 0.0117 | 0.0176 | 0.02 |
Onchocerca volvulus | 0.0107 | 0 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0107 | 0 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0107 | 0 | 0.5 |
Onchocerca volvulus | 0.0107 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0366 | 0.4351 | 0.4931 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0685 | 0.9722 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0632 | 0.8824 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0107 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0632 | 0.8824 | 1 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0366 | 0.4351 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0632 | 0.8824 | 0.9076 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0366 | 0.4351 | 0.4931 |
Onchocerca volvulus | 0.0107 | 0 | 0.5 | |
Loa Loa (eye worm) | integrin beta-2 | 0.0378 | 0.4563 | 0.5171 |
Echinococcus multilocularis | integrin beta 2 | 0.028 | 0.2915 | 0.2999 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0366 | 0.4351 | 0.5 |
Brugia malayi | Serotonin receptor | 0.0473 | 0.6161 | 0.6982 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0107 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0632 | 0.8824 | 0.8824 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.1347 | 0.1526 |
Onchocerca volvulus | 0.0107 | 0 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0632 | 0.8824 | 0.9076 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0107 | 0 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0632 | 0.8824 | 0.8824 |
Onchocerca volvulus | 0.0107 | 0 | 0.5 | |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0117 | 0.0176 | 0.02 |
Schistosoma mansoni | integrin beta subunit | 0.0223 | 0.1949 | 0.2209 |
Echinococcus granulosus | integrin beta 2 | 0.028 | 0.2915 | 0.2915 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0632 | 0.8824 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0632 | 0.8824 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0632 | 0.8824 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0632 | 0.8824 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0366 | 0.4351 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0107 | 0 | 0.5 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0378 | 0.4563 | 0.5171 |
Loa Loa (eye worm) | hypothetical protein | 0.0632 | 0.8824 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.43 uM | Antagonist activity at VLA-4 receptor in human U937 cells assessed as inhibition of VCAM-1 binding by MTT assay | ChEMBL. | 23312947 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.