Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutaminyl-peptide cyclotransferase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Schistosoma japonicum | ko:K00683 glutaminyl-peptide cyclotransferase [EC2.3.2.5], putative | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Brugia malayi | Peptidase family M28 containing protein | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Onchocerca volvulus | Glutaminyl cyclase homolog | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | glutaminyl-peptide cyclotransferase | 361 aa | 292 aa | 21.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | formin 2, putative | 0.0029 | 0 | 0.5 |
Trypanosoma cruzi | tyrosine phosphatase isoform, putative | 0.0029 | 0 | 0.5 |
Brugia malayi | Peptidase family M28 containing protein | 0.0136 | 0.4156 | 0.4156 |
Entamoeba histolytica | Pten 3-phosphoinositide phosphatase, putative | 0.0029 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.4156 | 0.4156 |
Entamoeba histolytica | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase, putative | 0.0029 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0288 | 1 | 1 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0136 | 0.4156 | 0.5 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.0136 | 0.4156 | 0.4156 |
Echinococcus multilocularis | cyclin g associated kinase | 0.0288 | 1 | 1 |
Leishmania major | tyrosine phosphatase isoform, putative | 0.0029 | 0 | 0.5 |
Echinococcus granulosus | cyclin g associated kinase | 0.0288 | 1 | 1 |
Trichomonas vaginalis | pten, drome, putative | 0.0029 | 0 | 0.5 |
Loa Loa (eye worm) | NAK/GAK protein kinase | 0.0288 | 1 | 1 |
Trypanosoma cruzi | tyrosine phosphatase isoform, putative | 0.0029 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0029 | 0 | 0.5 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.0136 | 0.4156 | 0.4156 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.0136 | 0.4156 | 0.4156 |
Trypanosoma cruzi | tyrosine phosphatase, putative | 0.0029 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.8847 | 0.8847 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 453 nM | Inhibition of human glutaminyl cyclase expressed in HEK293 cells using L-glutaminyl-beta-naphthylamine as substrate after 1 hr by fluorometric analysis | ChEMBL. | 23643900 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.