Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0742 | 0.4871 | 0.4871 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0238 | 0.0238 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.0918 | 0.0918 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1388 | 0.9168 | 0.5 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0742 | 0.4871 | 0.4871 |
Echinococcus granulosus | twitchin | 0.0012 | 0.0016 | 0.0016 |
Toxoplasma gondii | hypothetical protein | 0.0742 | 0.4871 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0742 | 0.4871 | 0.4871 |
Echinococcus multilocularis | roundabout 2 | 0.0015 | 0.0036 | 0.0036 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.1388 | 0.9168 | 0.5 |
Echinococcus granulosus | carbonic anhydrase II | 0.1513 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0036 | 0.0036 |
Echinococcus granulosus | neuroglian | 0.0012 | 0.0016 | 0.0016 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0238 | 0.0238 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0151 | 0.094 | 0.094 |
Schistosoma mansoni | nephrin | 0.0012 | 0.0016 | 0.0016 |
Schistosoma mansoni | carbonic anhydrase | 0.1388 | 0.9168 | 0.9168 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.0918 | 0.0918 |
Echinococcus multilocularis | neuroglian | 0.0012 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0742 | 0.4871 | 0.4871 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1513 | 1 | 0.5 |
Echinococcus multilocularis | muscleblind protein | 0.0147 | 0.0918 | 0.0918 |
Loa Loa (eye worm) | hypothetical protein | 0.0742 | 0.4871 | 0.4871 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0012 | 0.002 | 0.002 |
Trichomonas vaginalis | conserved hypothetical protein | 0.06 | 0.393 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.002 | 0.002 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0238 | 0.0238 |
Echinococcus granulosus | carbonic anhydrase | 0.0742 | 0.4871 | 0.4871 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0151 | 0.094 | 0.094 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0742 | 0.4871 | 0.4871 |
Loa Loa (eye worm) | hypothetical protein | 0.0742 | 0.4871 | 0.4871 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0238 | 0.0238 |
Echinococcus granulosus | carbonic anhydrase | 0.0742 | 0.4871 | 0.4871 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1513 | 1 | 1 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0141 | 0.0874 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0742 | 0.4871 | 0.4871 |
Trichomonas vaginalis | conserved hypothetical protein | 0.06 | 0.393 | 0.5 |
Schistosoma mansoni | carbonic anhydrase | 0.0742 | 0.4871 | 0.4871 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0742 | 0.4871 | 0.4871 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1513 | 1 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0238 | 0.0238 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0742 | 0.4871 | 0.4871 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0238 | 0.0238 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0742 | 0.4871 | 0.4871 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1513 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0238 | 0.0238 |
Brugia malayi | Muscleblind-like protein | 0.0147 | 0.0918 | 0.0918 |
Echinococcus multilocularis | carbonic anhydrase | 0.0742 | 0.4871 | 0.4871 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0238 | 0.0238 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.1513 | 1 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1513 | 1 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.1513 | 1 | 1 |
Echinococcus granulosus | roundabout 2 | 0.0015 | 0.0036 | 0.0036 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0788 | 0.5177 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0742 | 0.4871 | 0.4871 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0238 | 0.0238 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1388 | 0.9168 | 1 |
Leishmania major | carbonic anhydrase-like protein | 0.1513 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0742 | 0.4871 | 0.4871 |
Schistosoma mansoni | cell adhesion molecule | 0.0012 | 0.002 | 0.002 |
Echinococcus multilocularis | carbonic anhydrase II | 0.1513 | 1 | 1 |
Plasmodium falciparum | carbonic anhydrase | 0.0742 | 0.4871 | 0.5 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0147 | 0.0918 | 0.0918 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.1513 | 1 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0742 | 0.4871 | 0.4871 |
Loa Loa (eye worm) | hypothetical protein | 0.0742 | 0.4871 | 0.4871 |
Echinococcus granulosus | muscleblind protein | 0.0147 | 0.0918 | 0.0918 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0036 | 0.0036 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0742 | 0.4871 | 0.4871 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 40 uM | Cytotoxicity against human HeLa cells after 48 hrs by MTT assay | ChEMBL. | 23748152 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.