Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphodiesterase 4A, cAMP-specific | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.1216 | 1 | 0.5 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.1216 | 1 | 0.5 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.1216 | 1 | 0.5 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0703 | 0.541 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0284 | 0.1665 | 0.5 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0703 | 0.541 | 1 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0284 | 0.1665 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0122 | 0.073 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0284 | 0.1665 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.1216 | 1 | 0.5 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0284 | 0.1665 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0703 | 0.541 | 1 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0284 | 0.1665 | 0.2919 |
Plasmodium falciparum | DNA gyrase subunit B | 0.1216 | 1 | 1 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0112 | 0.0122 | 0.073 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0284 | 0.1665 | 1 |
Brugia malayi | Probable DNA topoisomerase II | 0.0284 | 0.1665 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.0887 | 0.533 |
Schistosoma mansoni | DNA topoisomerase II | 0.0284 | 0.1665 | 1 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.1216 | 1 | 1 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0284 | 0.1665 | 1 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0112 | 0.0122 | 0.073 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0703 | 0.541 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.0887 | 0.533 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0284 | 0.1665 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0703 | 0.541 | 1 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0284 | 0.1665 | 1 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0112 | 0.0122 | 0.073 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0284 | 0.1665 | 0.5 |
Giardia lamblia | DNA topoisomerase II | 0.0246 | 0.1324 | 1 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0284 | 0.1665 | 0.5 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0419 | 0.2868 | 0.5 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0112 | 0.0122 | 0.073 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 156 nM | Inhibition of human full length PDE4A4 expressed in baculovirus infected sf21 cells | ChEMBL. | 23806553 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.