Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protein kinase, AMP-activated, beta 1 non-catalytic subunit | Starlite/ChEMBL | No references |
Homo sapiens | activin A receptor, type I | Starlite/ChEMBL | No references |
Homo sapiens | activin A receptor, type IB | Starlite/ChEMBL | No references |
Homo sapiens | kinase insert domain receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | 5' AMP activated protein kinase subunit beta 1 | protein kinase, AMP-activated, beta 1 non-catalytic subunit | 270 aa | 236 aa | 47.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | lar interacting protein (lip)-related protein | 0.0112 | 0.0153 | 0.0153 |
Echinococcus granulosus | liprin beta 1 | 0.0112 | 0.0153 | 0.0153 |
Echinococcus granulosus | TGF-beta receptor type-1 | 0.0278 | 0.0414 | 0.0414 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0112 | 0.0153 | 0.5 |
Brugia malayi | Tnks protein | 0.0112 | 0.0153 | 0.0069 |
Brugia malayi | Liprin-alpha 2 | 0.0112 | 0.0153 | 0.0069 |
Echinococcus granulosus | AMPK beta subunit | 0.0068 | 0.0084 | 0.0084 |
Schistosoma mansoni | protein kinase | 0.0173 | 0.025 | 0.025 |
Plasmodium falciparum | protein kinase, putative | 0.0113 | 0.0155 | 0.5 |
Brugia malayi | Neurabin protein 1 | 0.0112 | 0.0153 | 0.0069 |
Echinococcus multilocularis | stromal interaction molecule 1 | 0.1409 | 0.2195 | 0.2191 |
Schistosoma mansoni | sarm1 | 0.0112 | 0.0153 | 0.0153 |
Schistosoma mansoni | Protein orai-1 | 0.6368 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0005 | 0.0005 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0183 | 0.0264 | 0.0181 |
Leishmania major | hypothetical protein, conserved | 0.0068 | 0.0084 | 0.5 |
Schistosoma mansoni | Protein orai-1 | 0.6368 | 1 | 1 |
Onchocerca volvulus | 0.0112 | 0.0153 | 0.4703 | |
Brugia malayi | hypothetical protein | 0.1409 | 0.2195 | 0.2129 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0153 | 0.0153 |
Echinococcus granulosus | SAM domain containing protein | 0.0112 | 0.0153 | 0.0153 |
Brugia malayi | hypothetical protein | 0.0147 | 0.0208 | 0.0125 |
Echinococcus multilocularis | activin receptor type | 0.0528 | 0.0808 | 0.0804 |
Echinococcus multilocularis | 5' AMP activated protein kinase subunit beta 1 | 0.0037 | 0.0035 | 0.003 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0183 | 0.0264 | 0.0264 |
Brugia malayi | sterile alpha and TIR motif containing protein 1 isoform a | 0.0112 | 0.0153 | 0.0069 |
Echinococcus multilocularis | liprin alpha 2 | 0.0112 | 0.0153 | 0.0148 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0112 | 0.0153 | 0.5 |
Onchocerca volvulus | 0.0112 | 0.0153 | 0.4703 | |
Echinococcus granulosus | liprin alpha 2 | 0.0112 | 0.0153 | 0.0153 |
Brugia malayi | Protein kinase domain containing protein | 0.0148 | 0.0209 | 0.0126 |
Onchocerca volvulus | 0.0167 | 0.0239 | 0.9649 | |
Loa Loa (eye worm) | TKL/STKR/TYPE1 protein kinase | 0.0278 | 0.0415 | 0.0415 |
Echinococcus granulosus | tankyrase | 0.0112 | 0.0153 | 0.0153 |
Loa Loa (eye worm) | hypothetical protein | 0.6368 | 1 | 1 |
Loa Loa (eye worm) | 5'-AMP-activated protein kinase | 0.0068 | 0.0084 | 0.0084 |
Trypanosoma brucei | 5'-AMP-activated protein kinase subunit beta | 0.0068 | 0.0084 | 0.5 |
Echinococcus multilocularis | tankyrase | 0.0112 | 0.0153 | 0.0148 |
Schistosoma mansoni | hypothetical protein | 0.0112 | 0.0153 | 0.0153 |
Echinococcus granulosus | TGF beta receptor type 1 | 0.0278 | 0.0414 | 0.0414 |
Echinococcus multilocularis | AMPK beta subunit | 0.0068 | 0.0084 | 0.008 |
Trypanosoma cruzi | SNF1-related protein kinase regulatory subunit beta, putative | 0.0068 | 0.0084 | 0.5 |
Echinococcus granulosus | sterile alpha and tir motif containing protein | 0.0112 | 0.0153 | 0.0153 |
Toxoplasma gondii | Tyrosine kinase-like (TKL) protein | 0.0112 | 0.0154 | 1 |
Schistosoma mansoni | tankyrase | 0.0112 | 0.0153 | 0.0153 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0112 | 0.0153 | 0.5 |
Giardia lamblia | 5-AMP-activated protein kinase, beta-1 subunit | 0.0068 | 0.0084 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0153 | 0.0153 |
Schistosoma mansoni | protein kinase subunit beta | 0.0068 | 0.0084 | 0.0084 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.0208 | 0.0208 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0153 | 0.0153 |
Schistosoma mansoni | hypothetical protein | 0.0112 | 0.0153 | 0.0153 |
Loa Loa (eye worm) | hypothetical protein | 0.1409 | 0.2195 | 0.2195 |
Echinococcus multilocularis | serine:threonine protein kinase receptor R3 | 0.0173 | 0.0249 | 0.0244 |
Echinococcus granulosus | activin receptor type | 0.0528 | 0.0808 | 0.0808 |
Plasmodium vivax | tyrosine kinase-like protein, putative | 0.0113 | 0.0155 | 0.5 |
Loa Loa (eye worm) | toll and interleukin 1 receptor domain-containing protein isoform f | 0.0112 | 0.0153 | 0.0153 |
Echinococcus multilocularis | liprin beta 1 | 0.0112 | 0.0153 | 0.0148 |
Echinococcus granulosus | calcium release activated calcium channel | 0.6368 | 1 | 1 |
Trichomonas vaginalis | c2h2 zinc finger protein, putative | 0.0112 | 0.0153 | 0.5 |
Schistosoma mansoni | lip-related protein (liprin) alpha | 0.0112 | 0.0153 | 0.0153 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0153 | 0.0153 |
Echinococcus granulosus | 5' AMP activated protein kinase subunit beta 1 | 0.0037 | 0.0035 | 0.0035 |
Schistosoma mansoni | hypothetical protein | 0.0645 | 0.0993 | 0.0992 |
Loa Loa (eye worm) | TKL/STKR/TYPE1 protein kinase | 0.0148 | 0.0209 | 0.0209 |
Plasmodium falciparum | tyrosine kinase-like protein | 0.0113 | 0.0155 | 0.5 |
Echinococcus multilocularis | calcium release activated calcium channel | 0.6368 | 1 | 1 |
Trypanosoma cruzi | 5'-AMP-activated protein kinase subunit beta, putative | 0.0068 | 0.0084 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0112 | 0.0153 | 0.5 |
Schistosoma mansoni | protein kinase | 0.0278 | 0.0414 | 0.0414 |
Echinococcus granulosus | stromal interaction molecule 1 | 0.1409 | 0.2195 | 0.2195 |
Schistosoma mansoni | hypothetical protein | 0.0764 | 0.1179 | 0.1179 |
Echinococcus multilocularis | sterile alpha and tir motif containing protein | 0.0112 | 0.0153 | 0.0148 |
Brugia malayi | coiled-coil like protein 1 | 0.0112 | 0.0153 | 0.0069 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0171 | 0.0245 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0005 | 0.0005 |
Echinococcus multilocularis | TGF beta receptor type 1 | 0.0278 | 0.0414 | 0.041 |
Schistosoma mansoni | hypothetical protein | 0.0112 | 0.0153 | 0.0153 |
Loa Loa (eye worm) | TKL/STKR/TYPE2 protein kinase | 0.0148 | 0.0209 | 0.0209 |
Brugia malayi | bone morphogenetic protein type 1 receptor | 0.0278 | 0.0415 | 0.0334 |
Echinococcus granulosus | Sterile alpha motif SAM | 0.0112 | 0.0153 | 0.0153 |
Echinococcus granulosus | roundabout 2 | 0.0018 | 0.0005 | 0.0005 |
Schistosoma mansoni | protein kinase subunit beta | 0.0037 | 0.0035 | 0.0034 |
Brugia malayi | hypothetical protein | 0.0112 | 0.0153 | 0.0069 |
Brugia malayi | protein C17H12.11 | 0.0147 | 0.0208 | 0.0125 |
Echinococcus multilocularis | SAM domain containing protein | 0.0112 | 0.0153 | 0.0148 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | Inhibition of BMP4 in mouse C2C12BRA cells after 14 hrs by luciferase reporter gene assay | ChEMBL. | 23639540 | |
IC50 (binding) | = 40.72 nM | BindingDB_Patents: Kinase Assay. Kinase assays were performed using the assay kit by Reaction Biology Corp (Malvern, Pa.). The compounds were tested at 10 concentrations by 3-fold serial dilutions starting at 30 µM. Staurosporin was used as a control nonspecific kinase inhibitor. In vitro kinase reactions using purified kinases were carried out in the presence of 10 µM ATP and test compounds. | ChEMBL. | No reference |
IC50 (binding) | = 565 nM | Kinase Assay | BINDINGDB. | No reference |
IC50 (binding) | = 1122 nM | BindingDB_Patents: Kinase Assay. Kinase assays were performed using the assay kit by Reaction Biology Corp (Malvern, Pa.). The compounds were tested at 10 concentrations by 3-fold serial dilutions starting at 30 uM. Staurosporin was used as a control nonspecific kinase inhibitor. In vitro kinase reactions using purified kinases were carried out in the presence of 10 uM ATP and test compounds. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.