Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Electrophorus electricus | Acetylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 633 aa | 690 aa | 31.7 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 633 aa | 576 aa | 23.4 % |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Acetylcholinesterase | 633 aa | 549 aa | 30.4 % |
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 633 aa | 690 aa | 32.3 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 633 aa | 517 aa | 25.1 % |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 633 aa | 622 aa | 24.9 % |
Onchocerca volvulus | Acetylcholinesterase | 633 aa | 648 aa | 25.3 % | |
Echinococcus multilocularis | neuroligin | Acetylcholinesterase | 633 aa | 507 aa | 23.9 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 633 aa | 620 aa | 28.4 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 633 aa | 597 aa | 25.1 % |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Acetylcholinesterase | 633 aa | 576 aa | 28.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | glycogen phosphorylase, putative | 0.1063 | 1 | 1 |
Echinococcus multilocularis | glycogen phosphorylase | 0.1063 | 1 | 0.5 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.1063 | 1 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.1063 | 1 | 0.5 |
Giardia lamblia | Glycogen phosphorylase | 0.1063 | 1 | 0.5 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.1063 | 1 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.1063 | 1 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.1063 | 1 | 1 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.1063 | 1 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.1063 | 1 | 0.5 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.1063 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0459 | 0 | 0.5 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0459 | 0 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.1063 | 1 | 1 |
Chlamydia trachomatis | glycogen phosphorylase | 0.1063 | 1 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.1063 | 1 | 0.5 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.1063 | 1 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.1063 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.607 uM | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate incubated for 6 mins prior to substrate addition measured after 60 to 180 secs by Ellman's method | ChEMBL. | 23511019 |
IC50 (binding) | > 100 uM | Inhibition of equine serum BuChE using S-butyrylthiocholine iodide as substrate incubated for 6 mins prior to substrate addition measured after 60 to 180 secs by Ellman's method | ChEMBL. | 23511019 |
Inhibition (binding) | = 22.08 % | Inhibition of amyloid beta (1 to 42) (unknown origin) aggregation at 20 uM by thioflavin T based fluorometric assay | ChEMBL. | 23511019 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.