Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | chromatin regulatory protein sir2 | 0.7401 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2634 | 0.1989 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.2634 | 0.1989 | 0.1989 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.4231 | 0.4673 | 0.4673 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.7401 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2781 | 0.2235 | 0.2235 |
Echinococcus multilocularis | NAD dependent deacetylase sirtuin 1 | 0.4231 | 0.4673 | 0.4673 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.7401 | 1 | 1 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.4231 | 0.4673 | 0.4673 |
Loa Loa (eye worm) | transcriptional regulator | 0.7401 | 1 | 1 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.7401 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.2634 | 0.1989 | 0.1989 |
Trypanosoma cruzi | Silent information regulator 2 related protein 1 | 0.7401 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.7401 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2634 | 0.1989 | 0.1989 |
Giardia lamblia | NAD-dependent histone deacetylase Sir2 | 0.4231 | 0.4673 | 0.4673 |
Onchocerca volvulus | 0.2634 | 0.1989 | 0.5 | |
Echinococcus multilocularis | chromatin regulatory protein sir2 | 0.7401 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.4231 | 0.4673 | 0.4673 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.4231 | 0.4673 | 0.4673 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.7401 | 1 | 1 |
Trypanosoma cruzi | Silent information regulator 2 related protein 1 | 0.7401 | 1 | 1 |
Brugia malayi | thymidylate synthase | 0.2634 | 0.1989 | 0.1989 |
Entamoeba histolytica | Sir2 family transcriptional regulator, putative | 0.7401 | 1 | 1 |
Schistosoma mansoni | chromatin regulatory protein sir2 | 0.4231 | 0.4673 | 0.4673 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.2634 | 0.1989 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.2634 | 0.1989 | 0.1989 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.2634 | 0.1989 | 0.5 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.4231 | 0.4673 | 0.4673 |
Echinococcus multilocularis | NAD dependent deacetylase sirtuin 3 | 0.7401 | 1 | 1 |
Echinococcus granulosus | NAD dependent deacetylase sirtuin 3 | 0.7401 | 1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.2634 | 0.1989 | 1 |
Trichomonas vaginalis | chromatin regulatory protein sir2, putative | 0.7401 | 1 | 1 |
Brugia malayi | NAD-dependent deacetylase SIRT1 | 0.4231 | 0.4673 | 0.4673 |
Leishmania major | silent information regulator 2, putative | 0.7401 | 1 | 1 |
Echinococcus granulosus | NAD dependent deacetylase sirtuin 1 | 0.4231 | 0.4673 | 0.4673 |
Entamoeba histolytica | Sir2 family transcriptional regulator, putative | 0.7401 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.2634 | 0.1989 | 0.1989 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.2634 | 0.1989 | 1 |
Trypanosoma brucei | Silent information regulator 2 related protein 1 | 0.7401 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2634 | 0.1989 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.2634 | 0.1989 | 0.1989 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.2634 | 0.1989 | 0.1989 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.