Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dopamine D2 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | g protein coupled receptor | Dopamine D2 receptor | 444 aa | 465 aa | 21.5 % |
Schistosoma japonicum | ko:K04145 dopamine receptor D2, putative | Dopamine D2 receptor | 444 aa | 432 aa | 30.8 % |
Schistosoma japonicum | ko:K04207 neuropeptide Y receptor Y5, putative | Dopamine D2 receptor | 444 aa | 386 aa | 19.7 % |
Loa Loa (eye worm) | hypothetical protein | Dopamine D2 receptor | 444 aa | 433 aa | 21.2 % |
Onchocerca volvulus | Glycoprotein hormone beta 5 homolog | Dopamine D2 receptor | 444 aa | 476 aa | 24.2 % |
Schistosoma mansoni | biogenic amine (dopamine) receptor | Dopamine D2 receptor | 444 aa | 494 aa | 26.3 % |
Schistosoma mansoni | muscarinic acetylcholine (GAR) receptor | Dopamine D2 receptor | 444 aa | 487 aa | 23.8 % |
Onchocerca volvulus | Dopamine D2 receptor | 444 aa | 418 aa | 23.0 % | |
Schistosoma mansoni | amine GPCR | Dopamine D2 receptor | 444 aa | 424 aa | 32.1 % |
Schistosoma japonicum | Octopamine receptor, putative | Dopamine D2 receptor | 444 aa | 456 aa | 29.4 % |
Schistosoma mansoni | biogenic amine receptor | Dopamine D2 receptor | 444 aa | 452 aa | 30.1 % |
Onchocerca volvulus | RB1-inducible coiled-coil protein 1 homolog | Dopamine D2 receptor | 444 aa | 474 aa | 23.4 % |
Echinococcus multilocularis | serotonin receptor | Dopamine D2 receptor | 444 aa | 428 aa | 31.3 % |
Schistosoma japonicum | ko:K04136 adrenergic receptor, alpha 1b, putative | Dopamine D2 receptor | 444 aa | 440 aa | 30.0 % |
Echinococcus granulosus | g protein coupled receptor | Dopamine D2 receptor | 444 aa | 457 aa | 21.0 % |
Echinococcus granulosus | biogenic amine 5HT receptor | Dopamine D2 receptor | 444 aa | 429 aa | 31.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.1806 | 0.5 | 0.5 |
Schistosoma mansoni | inositol transporter | 0.1806 | 0.5 | 0.5 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.1806 | 0.5 | 0.5 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.1806 | 0.5 | 0.5 |
Schistosoma mansoni | inositol transporter | 0.1806 | 0.5 | 0.5 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.1806 | 0.5 | 0.5 |
Echinococcus granulosus | solute carrier family 5 | 0.1806 | 0.5 | 0.5 |
Echinococcus multilocularis | solute carrier family 5 | 0.1806 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 4.3 mg kg-1 | In vivo inhibition of locomotor activity in the rat following p.o. administration. | ChEMBL. | 8759640 |
ED50 (functional) | = 4.7 mg kg-1 | Compound was tested for the inhibition of locomotor activity(LMA)by administering Intraperitoneally in mouse. | ChEMBL. | 8759640 |
ED50 (functional) | = 4.7 mg kg-1 | Compound was tested for the inhibition of locomotor activity(LMA)by administering Intraperitoneally in mouse. | ChEMBL. | 8759640 |
Ki (binding) | = 1673 nM | Binding affinity at Dopamine receptor D2 in rat striatal membrane by [3H]-spiperone displacement. | ChEMBL. | 8759640 |
Ki (binding) | = 1673 nM | Binding affinity at Dopamine receptor D2 in rat striatal membrane by [3H]-spiperone displacement. | ChEMBL. | 8759640 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.