Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ORAI calcium release-activated calcium modulator 3 | Starlite/ChEMBL | References |
Homo sapiens | ORAI calcium release-activated calcium modulator 2 | Starlite/ChEMBL | References |
Homo sapiens | transient receptor potential cation channel, subfamily V, member 6 | Starlite/ChEMBL | References |
Homo sapiens | ORAI calcium release-activated calcium modulator 1 | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | TRP channel protein nanchung | transient receptor potential cation channel, subfamily V, member 6 | 725 aa | 595 aa | 27.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | exocyst complex component 2 | 0.0004 | 0.0003 | 0.0003 |
Entamoeba histolytica | tyrosin kinase, putative | 0.0005 | 0.001 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0004 | 0.0003 | 0.5 |
Echinococcus multilocularis | RUN | 0.0021 | 0.0133 | 0.0133 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0021 | 0.0133 | 0.0133 |
Brugia malayi | Sema domain containing protein | 0.0008 | 0.0038 | 0.0035 |
Echinococcus granulosus | RUN | 0.0021 | 0.0133 | 0.0133 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0133 | 0.013 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.0038 | 0.0035 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0021 | 0.0133 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.0683 | 0.0681 |
Brugia malayi | olfactory channel protein osm-9 | 0.0093 | 0.0683 | 0.0681 |
Loa Loa (eye worm) | doublecortin family protein | 0.0021 | 0.0133 | 0.013 |
Schistosoma mansoni | hypothetical protein | 0.0008 | 0.0038 | 0.0035 |
Trichomonas vaginalis | Clan MA, family M8, leishmanolysin-like metallopeptidase | 0.0004 | 0.0003 | 0.5 |
Schistosoma mansoni | Protein orai-1 | 0.1323 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0123 | 0.012 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.0038 | 0.0035 |
Schistosoma mansoni | polycystin 1-related | 0.0021 | 0.0133 | 0.013 |
Brugia malayi | hypothetical protein | 0.0008 | 0.0038 | 0.0035 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0005 | 0.001 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0011 | 0.0062 | 0.0059 |
Loa Loa (eye worm) | hypothetical protein | 0.1323 | 1 | 1 |
Schistosoma mansoni | rab6-interacting | 0.0021 | 0.0133 | 0.013 |
Brugia malayi | hypothetical protein | 0.0021 | 0.0133 | 0.013 |
Schistosoma mansoni | lipoxygenase | 0.0087 | 0.0633 | 0.063 |
Schistosoma mansoni | lipoxygenase | 0.0124 | 0.0915 | 0.0912 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0133 | 0.013 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.0038 | 0.0035 |
Brugia malayi | Plexin repeat family protein | 0.0019 | 0.0123 | 0.012 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0021 | 0.0133 | 0.0133 |
Loa Loa (eye worm) | plexin A | 0.0023 | 0.015 | 0.0147 |
Echinococcus granulosus | semaphorin 5B | 0.0008 | 0.0038 | 0.0038 |
Brugia malayi | hypothetical protein | 0.0008 | 0.0038 | 0.0035 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.0038 | 0.0035 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0004 | 0.0003 | 0.5 |
Trichomonas vaginalis | Clan MA, family M8, leishmanolysin-like metallopeptidase | 0.0004 | 0.0003 | 0.5 |
Brugia malayi | plexin A | 0.0023 | 0.015 | 0.0147 |
Echinococcus multilocularis | semaphorin 5B | 0.0008 | 0.0038 | 0.0038 |
Loa Loa (eye worm) | sema domain-containing protein | 0.0008 | 0.0038 | 0.0035 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0004 | 0.0003 | 0.5 |
Brugia malayi | hypothetical protein | 0.0021 | 0.0133 | 0.013 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0021 | 0.0133 | 0.0133 |
Trichomonas vaginalis | Clan MA, family M8, leishmanolysin-like metallopeptidase | 0.0004 | 0.0003 | 0.5 |
Schistosoma mansoni | loxhd1 | 0.0021 | 0.0133 | 0.013 |
Onchocerca volvulus | 0.0021 | 0.0133 | 1 | |
Schistosoma mansoni | plexin | 0.0011 | 0.0062 | 0.0059 |
Schistosoma mansoni | hypothetical protein | 0.0008 | 0.0038 | 0.0035 |
Echinococcus multilocularis | plexin a4 | 0.0023 | 0.015 | 0.015 |
Trichomonas vaginalis | Clan MA, family M8, leishmanolysin-like metallopeptidase | 0.0004 | 0.0003 | 0.5 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0021 | 0.0133 | 0.0133 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0004 | 0.0003 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.0038 | 0.0035 |
Trichomonas vaginalis | Clan MA, family M8, leishmanolysin-like metallopeptidase | 0.0004 | 0.0003 | 0.5 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0021 | 0.0133 | 0.0133 |
Echinococcus granulosus | transcription factor collier | 0.0004 | 0.0003 | 0.0003 |
Schistosoma mansoni | Protein orai-1 | 0.1323 | 1 | 1 |
Onchocerca volvulus | 0.0021 | 0.0133 | 1 | |
Schistosoma mansoni | rab6-interacting | 0.0021 | 0.0133 | 0.013 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0004 | 0.0003 | 0.5 |
Schistosoma mansoni | plexin | 0.0019 | 0.0123 | 0.012 |
Schistosoma mansoni | semaphorin 5-related | 0.0008 | 0.0038 | 0.0035 |
Echinococcus multilocularis | calcium release activated calcium channel | 0.1323 | 1 | 1 |
Echinococcus multilocularis | hypothetical protein | 0.0008 | 0.0038 | 0.0038 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0021 | 0.0133 | 0.5 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0124 | 0.0915 | 0.0915 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0133 | 0.013 |
Echinococcus multilocularis | transcription factor collier | 0.0004 | 0.0003 | 0.0003 |
Brugia malayi | Doublecortin family protein | 0.0021 | 0.0133 | 0.013 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0004 | 0.0003 | 0.5 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0124 | 0.0915 | 0.0915 |
Echinococcus granulosus | semaphorin 1A | 0.0008 | 0.0038 | 0.0038 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0062 | 0.0059 |
Echinococcus granulosus | calcium release activated calcium channel | 0.1323 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0004 | 0.0003 | 0.5 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0021 | 0.0133 | 0.0133 |
Brugia malayi | Sema domain containing protein | 0.0008 | 0.0038 | 0.0035 |
Echinococcus multilocularis | exocyst complex component 2 | 0.0004 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | sema domain-containing protein | 0.0008 | 0.0038 | 0.0035 |
Onchocerca volvulus | 0.0019 | 0.0123 | 0.8964 | |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.0038 | 0.0035 |
Echinococcus granulosus | plexin a4 | 0.0023 | 0.015 | 0.015 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3.4 uM | Inhibition of ORAl1/2/3 in HEK293 cells assessed as inhibition of Ca2+ influx after 10 mins by FLIPR assay in presence of thapsigargin | ChEMBL. | 23602525 |
IC50 (binding) | = 4.9 uM | Inhibition of ORAl1/2/3 in HEK293 cells assessed as inhibition of Cd2+ influx after 10 mins by FLIPR assay in presence of thapsigargin | ChEMBL. | 23602525 |
IC50 (binding) | = 9.8 uM | Inhibition of human TRPV6 transfected in HEK293 cells assessed as inhibition of Cd2+ influx after 5 mins by FLIPR assay | ChEMBL. | 23602525 |
IC50 (binding) | = 13.2 uM | Inhibition of human TRPV6 transfected in HEK293 cells assessed as inhibition of Ca2+ influx after 5 mins by FLIPR assay | ChEMBL. | 23602525 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.