Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | cytochrome P450, putative | 0.0041 | 0.1196 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0041 | 0.1196 | 0.1196 |
Mycobacterium ulcerans | Holliday junction DNA helicase RuvA | 0.0069 | 0.5261 | 1 |
Trypanosoma cruzi | meiotic recombination protein DMC1, putative | 0.0102 | 1 | 1 |
Schistosoma mansoni | DNA repair protein RAD51 | 0.0102 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0041 | 0.1196 | 0.1196 |
Giardia lamblia | DNA helicase | 0.0069 | 0.5261 | 1 |
Trypanosoma cruzi | DNA repair protein RAD51, putative | 0.0102 | 1 | 1 |
Toxoplasma gondii | DNA repair protein rad10 subfamily protein | 0.0069 | 0.5261 | 0.5261 |
Mycobacterium leprae | Probable Holliday junction DNA helicase component RuvA | 0.0069 | 0.5261 | 0.5 |
Plasmodium falciparum | DNA repair protein RAD51 | 0.0033 | 0 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0033 | 0.0073 | 0.0073 |
Trichomonas vaginalis | meiosis-specific recA homolog Dmc1 | 0.0102 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0041 | 0.1196 | 0.1196 |
Treponema pallidum | Holliday junction DNA helicase (ruvA) | 0.0069 | 0.5261 | 0.5 |
Chlamydia trachomatis | DNA ligase | 0.0069 | 0.5261 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0041 | 0.1196 | 0.1196 |
Loa Loa (eye worm) | rad51 | 0.0102 | 1 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0041 | 0.1196 | 0.1196 |
Mycobacterium ulcerans | excinuclease ABC subunit C | 0.0069 | 0.5261 | 1 |
Trypanosoma cruzi | DNA repair protein RAD51, putative | 0.0102 | 1 | 1 |
Plasmodium vivax | meiotic recombination protein DMC1, putative | 0.0033 | 0 | 0.5 |
Leishmania major | RAD51/dmc1 protein | 0.0102 | 1 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0041 | 0.1196 | 0.1196 |
Chlamydia trachomatis | exodeoxyribonuclease V subunit alpha | 0.0069 | 0.5261 | 0.5 |
Echinococcus granulosus | dna repair protein rad51 1 | 0.0102 | 1 | 1 |
Plasmodium vivax | DNA repair protein RAD51, putative | 0.0033 | 0 | 0.5 |
Chlamydia trachomatis | Holliday junction ATP-dependent DNA helicase RuvA | 0.0069 | 0.5261 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | Holliday junction DNA helicase RuvA | 0.0069 | 0.5261 | 0.5 |
Entamoeba histolytica | DNA repair protein RAD51, putative | 0.0102 | 1 | 1 |
Onchocerca volvulus | Meiotic recombination protein DMC1\/LIM15 homolog | 0.0033 | 0 | 0.5 |
Plasmodium falciparum | meiotic recombination protein DMC1, putative | 0.0033 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | transcription elongation factor NusA | 0.0069 | 0.5261 | 0.5 |
Toxoplasma gondii | meiotic recombination protein DMC1 family protein | 0.0102 | 1 | 1 |
Mycobacterium tuberculosis | Probable holliday junction DNA helicase RuvA | 0.0069 | 0.5261 | 0.5 |
Chlamydia trachomatis | excinuclease ABC subunit C | 0.0069 | 0.5261 | 0.5 |
Trypanosoma cruzi | meiotic recombination protein DMC1, putative | 0.0102 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0033 | 0.0073 | 0.0073 |
Echinococcus multilocularis | dna repair protein rad51 1 | 0.0102 | 1 | 1 |
Giardia lamblia | hypothetical protein | 0.0069 | 0.5261 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.