Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucokinase (hexokinase 4) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hexokinase family protein | glucokinase (hexokinase 4) | 465 aa | 470 aa | 30.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | hexokinase | 0.0096 | 1 | 0.5 |
Trypanosoma brucei | hexokinase, putative | 0.0096 | 1 | 0.5 |
Plasmodium vivax | hexokinase, putative | 0.0096 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase type 2 | 0.0096 | 1 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.0096 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0096 | 1 | 1 |
Schistosoma mansoni | hexokinase | 0.0096 | 1 | 0.5 |
Onchocerca volvulus | 0.0096 | 1 | 1 | |
Brugia malayi | Hexokinase family protein | 0.0096 | 1 | 1 |
Echinococcus granulosus | hexokinase type 2 | 0.0096 | 1 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0096 | 1 | 0.5 |
Leishmania major | hexokinase, putative | 0.0096 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0096 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0096 | 1 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0096 | 1 | 0.5 |
Treponema pallidum | hexokinase (hxk) | 0.0096 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0096 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.1468 | 0.1468 |
Loa Loa (eye worm) | hexokinase | 0.0096 | 1 | 1 |
Trypanosoma cruzi | hexokinase, putative | 0.0096 | 1 | 0.5 |
Toxoplasma gondii | hexokinase | 0.0096 | 1 | 0.5 |
Plasmodium falciparum | hexokinase | 0.0096 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0096 | 1 | 0.5 |
Entamoeba histolytica | hexokinase 1 | 0.0096 | 1 | 0.5 |
Onchocerca volvulus | 0.0096 | 1 | 1 | |
Entamoeba histolytica | hexokinase 2 | 0.0096 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase type II | 0.0096 | 1 | 1 |
Onchocerca volvulus | 0.0096 | 1 | 1 | |
Leishmania major | hexokinase, putative | 0.0096 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0096 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 2.8 mM | Activation of human glucokinase assessed as glucose concentration at enzyme's half-maximal phosphorylation rate at 50 uM | ChEMBL. | 24015910 |
EC50 (binding) | = 562 nM | Allosteric activation of human glucokinase using glucose as substrate measured every 10 secs for 5 mins | ChEMBL. | 24015910 |
Vmax (binding) | = 106 % | Activity of human glucokinase at 50 uM | ChEMBL. | 24015910 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.