Detailed information for compound 1786048

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 280.303 | Formula: C11H12N4O3S
  • H donors: 3 H acceptors: 4 LogP: -0.05 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: ONC(=O)c1cnc(s1)CNC(=O)c1cccn1C
  • InChi: 1S/C11H12N4O3S/c1-15-4-2-3-7(15)10(16)13-6-9-12-5-8(19-9)11(17)14-18/h2-5,18H,6H2,1H3,(H,13,16)(H,14,17)
  • InChiKey: KYAAPEKSLXSDRR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens histone deacetylase 6 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Neospora caninum hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei histone deacetylase 3 Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium berghei histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 4, putative Get druggable targets OG5_126654 All targets in OG5_126654
Theileria parva histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma cruzi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 6, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 10, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei histone deacetylase 4 Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium knowlesi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Babesia bovis histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium vivax histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma mansoni histone deacetylase hda2 Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma cruzi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium yoelii hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma cruzi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma congolense histone deacetylase 4 Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei gambiense histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Toxoplasma gondii histone deacetylase HDAC1 Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium yoelii Histone deacetylase family, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma mansoni histone deacetylase 4 5 Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania major histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Cryptosporidium parvum histone deactylase of possible bacterial origin with ankyrin repeats at the N-terminus Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma mansoni histone deacetylase 4 5 Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium berghei histone deacetylase 2, putative Get druggable targets OG5_126654 All targets in OG5_126654
Theileria parva hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 6, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium vivax histone deacetylase 2, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Loa Loa (eye worm) histone deacetylase Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum IPR000286,Histone deacetylase superfamily;IPR013838,Beta tubulin, autoregulation binding site,domain-containing Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium falciparum histone deacetylase 2 Get druggable targets OG5_126654 All targets in OG5_126654
Candida albicans strong similarity to S. cerevisiae HDA1 (YNL021W) class II histone deacetylase HDA1 complex subunit Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium knowlesi histone deacetylase 2, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma congolense histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Brugia malayi Histone deacetylase family protein Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium falciparum histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania major histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 10, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 7 Get druggable targets OG5_126654 All targets in OG5_126654
Theileria parva hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Brugia malayi Histone deacetylase family protein Get druggable targets OG5_126654 All targets in OG5_126654
Candida albicans strong similarity to S. cerevisiae HDA1 (YNL021W) class II histone deacetylase HDA1 complex subunit Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma congolense histone deacetylase 4 Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 4, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 7 Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Loa Loa (eye worm) histone deacetylase 7A Get druggable targets OG5_126654 All targets in OG5_126654
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus carbonic anhydrase 0.0107 0.0641 0.0624
Echinococcus multilocularis Tolloid protein 1 0.006 0.0273 0.0255
Trypanosoma cruzi histone deacetylase, putative 0.0049 0.0187 0.0805
Loa Loa (eye worm) hypothetical protein 0.0034 0.0075 0.0075
Echinococcus multilocularis histone deacetylase 7 0.0049 0.0187 0.0169
Loa Loa (eye worm) AStacin protease 0.0037 0.0101 0.0101
Echinococcus multilocularis carbonic anhydrase II 0.0198 0.1343 0.1327
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0019
Toxoplasma gondii histone deacetylase HDAC1 0.0049 0.0187 0.2261
Trypanosoma brucei carbonic anhydrase-like protein 0.0198 0.1343 0.7825
Loa Loa (eye worm) melatonin receptor type 1A 0.0027 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0019
Schistosoma mansoni glycogen phosphorylase 0.0098 0.0568 0.0551
Echinococcus granulosus Tolloid protein 1 0.006 0.0273 0.0255
Loa Loa (eye worm) neuropeptide F receptor 0.0027 0.0019 0.0019
Entamoeba histolytica glycogen phosphorylase, putative 0.0098 0.0568 0.2748
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0019
Schistosoma mansoni carbonic anhydrase-related 0.0107 0.0641 0.0624
Onchocerca volvulus Glycogen phosphorylase homolog 0.0098 0.0568 0.4173
Schistosoma mansoni glycogen phosphorylase 0.0098 0.0568 0.0551
Mycobacterium ulcerans carbonic anhydrase 0.0988 0.7438 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0019
Loa Loa (eye worm) pre-B cell enhancing factor 0.132 1 1
Schistosoma mansoni hypothetical protein 0.0107 0.0641 0.0624
Echinococcus granulosus carbonic anhydrase 0.0107 0.0641 0.0624
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0228 0.1572 0.2068
Mycobacterium leprae Probable transmembrane transport protein 0.0228 0.1572 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0019
Echinococcus granulosus carbonic anhydrase 0.0107 0.0641 0.0624
Echinococcus multilocularis glycogen phosphorylase 0.0098 0.0568 0.0551
Chlamydia trachomatis glycogen phosphorylase 0.0098 0.0568 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0019
Schistosoma mansoni carbonic anhydrase-related 0.0107 0.0641 0.0624
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0019
Trypanosoma brucei nicotinate phosphoribosyltransferase, putative 0.0245 0.1702 1
Loa Loa (eye worm) carbonic anhydrase 3 0.0198 0.1343 0.1343
Echinococcus multilocularis carbonic anhydrase 0.0107 0.0641 0.0624
Echinococcus granulosus Glycosyl transferase family 35 0.0098 0.0568 0.0551
Trichomonas vaginalis nicotinate phosphoribosyltransferase, putative 0.0245 0.1702 0.165
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0198 0.1343 0.7825
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0019
Mycobacterium tuberculosis Nicotinic acid phosphoribosyltransferase PncB2 0.0245 0.1702 0.2254
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0019
Plasmodium falciparum histone deacetylase 2 0.0049 0.0187 0.0805
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0019
Treponema pallidum nicotinate phosphoribosyltransferase 0.0245 0.1702 0.5
Plasmodium falciparum carbonic anhydrase 0.0107 0.0641 0.3562
Echinococcus multilocularis histone deacetylase 6 0.0056 0.0245 0.0227
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0019
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0027 0.0019 0.0019
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0198 0.1343 0.1327
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0107 0.0641 0.0624
Loa Loa (eye worm) neuropeptide F receptor 0.0027 0.0019 0.0019
Loa Loa (eye worm) TYRA-2 protein 0.0027 0.0019 0.0019
Plasmodium vivax histone deacetylase, putative 0.0049 0.0187 1
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.0276 0.194 0.2598
Echinococcus multilocularis histone deacetylase 0.0049 0.0187 0.0169
Loa Loa (eye worm) G-protein coupled receptor 0.0027 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0019
Schistosoma mansoni nicotinate phosphoribosyltransferase 0.0245 0.1702 0.1686
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0027 0.0019 0.0019
Echinococcus multilocularis nicotinamide phosphoribosyltransferase 0.132 1 1
Entamoeba histolytica glycogen phosphorylase, putative 0.0098 0.0568 0.2748
Mycobacterium tuberculosis Beta-carbonic anhydrase 0.094 0.707 1
Echinococcus granulosus nicotinamide phosphoribosyltransferase 0.132 1 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0019
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0198 0.1343 0.7825
Schistosoma mansoni histone deacetylase 4 5 0.0049 0.0187 0.0169
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0019
Echinococcus granulosus glycogen phosphorylase 0.0098 0.0568 0.0551
Loa Loa (eye worm) hypothetical protein 0.0107 0.0641 0.0641
Schistosoma mansoni nicotinate phosphoribosyltransferase related pre-B cell enhancing factor 0.132 1 1
Echinococcus multilocularis histone deacetylase 6 0.0049 0.0187 0.0169
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0198 0.1343 0.1327
Onchocerca volvulus 0.0197 0.1336 1
Echinococcus granulosus histone deacetylase 6 0.0049 0.0187 0.0169
Onchocerca volvulus Putative sulfate transporter 0.0197 0.1336 1
Loa Loa (eye worm) hypothetical protein 0.0107 0.0641 0.0641
Trichomonas vaginalis conserved hypothetical protein 0.0988 0.7438 1
Trypanosoma brucei histone deacetylase 3 0.0049 0.0187 0.0805
Giardia lamblia Glycogen phosphorylase 0.0098 0.0568 0.5
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.006 0.0273 0.0255
Echinococcus multilocularis carbonic anhydrase 0.0107 0.0641 0.0624
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0019
Schistosoma mansoni carbonic anhydrase 0.0048 0.018 0.0161
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0019
Echinococcus granulosus histone deacetylase 7 0.0049 0.0187 0.0169
Mycobacterium tuberculosis Nicotinic acid phosphoribosyltransferase PncB1 0.0245 0.1702 0.2254
Echinococcus granulosus histone deacetylase 6 0.0049 0.0187 0.0169
Echinococcus granulosus histone deacetylase 6 0.0056 0.0245 0.0227
Echinococcus multilocularis glycogen phosphorylase 0.0098 0.0568 0.0551
Mycobacterium ulcerans carbonic anhydrase 0.0048 0.018 0.0169
Echinococcus granulosus carbonic anhydrase II 0.0198 0.1343 0.1327
Trypanosoma cruzi histone deacetylase, putative 0.0049 0.0187 0.0805
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0019
Leishmania major histone deacetylase, putative 0.0049 0.0187 0.005
Trypanosoma cruzi nicotinate phosphoribosyltransferase, putative 0.0245 0.1702 1
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0198 0.1343 0.1343
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0027 0.0019 0.0019
Schistosoma mansoni nicotinate phosphoribosyltransferase related pre-B cell enhancing factor 0.0245 0.1702 0.1686
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0107 0.0641 0.0641
Plasmodium vivax histone deacetylase 2, putative 0.0049 0.0187 1
Loa Loa (eye worm) G-protein coupled receptor 0.0027 0.0019 0.0019
Schistosoma mansoni histone deacetylase 4 5 0.0049 0.0187 0.0169
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0042 0.0139 0.0114
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0019
Entamoeba histolytica carbonic anhydrase, putative 0.0048 0.018 0.0261
Schistosoma mansoni carbonic anhydrase-related 0.0107 0.0641 0.0624
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0019
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0198 0.1343 0.1327
Loa Loa (eye worm) hypothetical protein 0.0057 0.0255 0.0255
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0019
Echinococcus multilocularis histone deacetylase 6 0.0049 0.0187 0.0169
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0107 0.0641 0.0624
Loa Loa (eye worm) hypothetical protein 0.0041 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0019
Entamoeba histolytica nicotinate phosphoribosyltransferase, putative 0.0245 0.1702 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0019
Brugia malayi Histone deacetylase family protein 0.0049 0.0187 0.0169
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0019
Loa Loa (eye worm) histone deacetylase 0.0049 0.0187 0.0187
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0019
Trypanosoma brucei histone deacetylase 4 0.0049 0.0187 0.0805
Schistosoma mansoni histone deacetylase hda2 0.0056 0.0245 0.0227
Schistosoma mansoni carbonic anhydrase 0.0107 0.0641 0.0624
Echinococcus granulosus glycogen phosphorylase 0.0098 0.0568 0.0551
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0019
Leishmania major histone deacetylase, putative 0.0049 0.0187 0.005
Leishmania major carbonic anhydrase-like protein 0.0198 0.1343 0.7646
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0019
Echinococcus granulosus histone deacetylase 0.0049 0.0187 0.0169
Echinococcus multilocularis carbonic anhydrase 0.0107 0.0641 0.0624
Echinococcus multilocularis Glycosyl transferase, family 35 0.0098 0.0568 0.0551
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0107 0.0641 0.0624
Trypanosoma brucei histone deacetylase, putative 0.0049 0.0187 0.0805
Trichomonas vaginalis conserved hypothetical protein 0.0988 0.7438 1
Leishmania major nicotinate phosphoribosyltransferase, putative 0.0245 0.1702 1
Trypanosoma cruzi histone deacetylase, putative 0.0049 0.0187 0.0805
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0107 0.0641 0.0624
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0019
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0107 0.0641 0.0624
Schistosoma mansoni glycogen phosphorylase 0.0042 0.0139 0.0121
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0019
Plasmodium falciparum nicotinate phosphoribosyltransferase, putative 0.0245 0.1702 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0198 0.1343 0.1327
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0019
Plasmodium falciparum histone deacetylase, putative 0.0049 0.0187 0.0805
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0027 0.0019 0.0019
Toxoplasma gondii hypothetical protein 0.0107 0.0641 1
Loa Loa (eye worm) glycogen phosphorylase 0.0098 0.0568 0.0568
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0019
Brugia malayi carbohydrate phosphorylase 0.0098 0.0568 0.0551
Loa Loa (eye worm) bone morphogenetic protein 1b 0.006 0.0273 0.0273
Brugia malayi Histone deacetylase family protein 0.0049 0.0187 0.0169
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0027 0.0019 0.0019
Loa Loa (eye worm) histone deacetylase 7A 0.0049 0.0187 0.0187
Loa Loa (eye worm) hypothetical protein 0.0107 0.0641 0.0641
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0019

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 52 nM Inhibition of N-terminal GST-tagged recombinant HDAC6 (unknown origin) assessed as deacetylation of Ac-Arg-Gly-Lys (Ac) after 1 hr by fluorescence plate reader analysis in presence of trypsin ChEMBL. 23964961

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.