Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase | Starlite/ChEMBL | References |
Homo sapiens | cytochrome P450, family 3, subfamily A, polypeptide 4 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | cytochrome P450 | cytochrome P450, family 3, subfamily A, polypeptide 4 | 502 aa | 492 aa | 24.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0065 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0015 | 0.078 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0015 | 0.078 | 0.078 |
Echinococcus multilocularis | inhibitor of apoptosis protein | 0.0065 | 1 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0015 | 0.078 | 0.078 |
Schistosoma mansoni | inhibitor of apoptosis protein | 0.0065 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0015 | 0.078 | 0.5 |
Echinococcus granulosus | baculoviral IAP repeat containing protein | 0.0065 | 1 | 0.5 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.0065 | 1 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0015 | 0.078 | 0.5 |
Schistosoma mansoni | inhibitor of apoptosis (iap) domain family member | 0.0065 | 1 | 0.5 |
Echinococcus multilocularis | baculoviral IAP repeat containing protein | 0.0065 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0015 | 0.078 | 0.5 |
Onchocerca volvulus | 0.0065 | 1 | 0.5 | |
Loa Loa (eye worm) | CYP4Cod1 | 0.0015 | 0.078 | 0.078 |
Echinococcus granulosus | inhibitor of apoptosis protein | 0.0065 | 1 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0015 | 0.078 | 0.5 |
Onchocerca volvulus | Deterin homolog | 0.0065 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.182 uM | Displacement of AVPIAQKSEK (epsilon-biotin)-OH from 6xhistidine-thrombin-TEV-tagged XIAP BIR2 domain (124 to 240) (unknown origin) after 45 mins by TR-FRET Assay | ChEMBL. | 24093940 |
IC50 (ADMET) | = 38 uM | Inhibition of CYP3A4 (unknown origin) | ChEMBL. | 24093940 |
IC50 (binding) | > 54.8 uM | Displacement of AVPIAQKSEK (epsilon-biotin)-OH from 6xhistidine-thrombin-TEV-tagged XIAP BIR3 domain (241 to 356) (unknown origin) after 45 mins by TR-FRET Assay | ChEMBL. | 24093940 |
Ki (ADMET) | = 2.1 uM | Time-dependent inhibition of CYP3A4 in human liver microsomes assessed as midazolam hydroxylation by LC-MS/MS analysis | ChEMBL. | 24093940 |
Kinact (ADMET) | = 0.009 /min | Time-dependent inhibition of CYP3A4 in human liver microsomes assessed as midazolam hydroxylation by LC-MS/MS analysis | ChEMBL. | 24093940 |
Ratio (ADMET) | = 0.0041 L/min/umol | Ratio of Kinact to Ki for CYP3A4 in human liver microsomes | ChEMBL. | 24093940 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.