Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | Janus kinase 1 | Starlite/ChEMBL | References |
Homo sapiens | Janus kinase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0872 | 0.0821 |
Echinococcus granulosus | expressed protein | 0.0053 | 0.0872 | 0.0914 |
Echinococcus multilocularis | axis inhibition protein axin | 0.0053 | 0.0872 | 0.0914 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0053 | 0.0872 | 0.5 |
Echinococcus granulosus | axis inhibition protein axin | 0.0053 | 0.0872 | 0.0914 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0536 | 1 | 1 |
Onchocerca volvulus | 0.001 | 0.0056 | 0.5 | |
Brugia malayi | Probable G protein-coupled receptor kinase F19C6.1, putative | 0.0482 | 0.8989 | 0.8983 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.0053 | 0.0872 | 0.0821 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.0536 | 1 | 1 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.0482 | 0.8989 | 0.8983 |
Echinococcus granulosus | beta-adrenergic receptor kinase | 0.0055 | 0.0897 | 0.0941 |
Loa Loa (eye worm) | G protein-coupled receptor kinase 1 | 0.0482 | 0.8989 | 0.8983 |
Echinococcus granulosus | [G-protein-coupledreceptor] kinase | 0.0482 | 0.8989 | 1 |
Loa Loa (eye worm) | PXA domain-containing protein | 0.0053 | 0.0872 | 0.0821 |
Schistosoma mansoni | regulator of G protein signaling | 0.0053 | 0.0872 | 0.0821 |
Echinococcus multilocularis | axis inhibition protein axin | 0.0053 | 0.0872 | 0.0914 |
Entamoeba histolytica | hypothetical protein | 0.0053 | 0.0872 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0055 | 0.0897 | 0.0845 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0872 | 0.0821 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0012 | 0.0081 | 0.0027 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0053 | 0.0872 | 0.0914 |
Schistosoma mansoni | regulator of G protein signaling | 0.0053 | 0.0872 | 0.0821 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0053 | 0.0872 | 0.5 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0053 | 0.0872 | 0.0914 |
Schistosoma mansoni | regulator of G protein signaling | 0.0053 | 0.0872 | 0.0821 |
Schistosoma mansoni | axis inhibition protein axin | 0.0053 | 0.0872 | 0.0821 |
Onchocerca volvulus | 0.001 | 0.0056 | 0.5 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0053 | 0.0872 | 0.5 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.0053 | 0.0872 | 0.0821 |
Echinococcus multilocularis | regulator of G protein signaling | 0.0053 | 0.0872 | 0.0914 |
Brugia malayi | A-kinase anchor protein 10, precursor | 0.0053 | 0.0872 | 0.0821 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0053 | 0.0872 | 0.0914 |
Brugia malayi | PXA domain containing protein | 0.0053 | 0.0872 | 0.0821 |
Echinococcus multilocularis | G protein coupled receptor kinase 6 | 0.0482 | 0.8989 | 1 |
Loa Loa (eye worm) | RGS-3 protein | 0.0053 | 0.0872 | 0.0821 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.001 | 0.0056 | 0.0644 |
Echinococcus multilocularis | expressed protein | 0.0053 | 0.0872 | 0.0914 |
Brugia malayi | Regulator of G protein signaling domain containing protein | 0.0053 | 0.0872 | 0.0821 |
Echinococcus multilocularis | Regulator of G protein signaling 20 | 0.0053 | 0.0872 | 0.0914 |
Schistosoma mansoni | regulator of G protein signaling | 0.0053 | 0.0872 | 0.0821 |
Echinococcus multilocularis | A kinase anchor protein 10, mitochondrial | 0.0053 | 0.0872 | 0.0914 |
Echinococcus multilocularis | beta adrenergic receptor kinase | 0.0055 | 0.0897 | 0.0941 |
Onchocerca volvulus | 0.001 | 0.0056 | 0.5 | |
Trichomonas vaginalis | regulator of G protein signaling 5, rgs5, putative | 0.0053 | 0.0872 | 0.5 |
Echinococcus granulosus | axis inhibition protein axin | 0.0053 | 0.0872 | 0.0914 |
Echinococcus granulosus | regulator of G protein signaling 3 | 0.0053 | 0.0872 | 0.0914 |
Onchocerca volvulus | 0.001 | 0.0056 | 0.5 | |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.0053 | 0.0872 | 0.0821 |
Onchocerca volvulus | 0.001 | 0.0056 | 0.5 | |
Entamoeba histolytica | hypothetical protein | 0.0053 | 0.0872 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0053 | 0.0872 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0053 | 0.0872 | 1 |
Brugia malayi | hypothetical protein | 0.0053 | 0.0872 | 0.0821 |
Onchocerca volvulus | 0.001 | 0.0056 | 0.5 | |
Schistosoma mansoni | serine/threonine protein kinase | 0.0055 | 0.0897 | 0.0845 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0872 | 0.0821 |
Schistosoma mansoni | axis inhibition protein axin | 0.0053 | 0.0872 | 0.0821 |
Brugia malayi | PXA domain containing protein | 0.0053 | 0.0872 | 0.0821 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0053 | 0.0872 | 0.5 |
Brugia malayi | Regulator of G protein signaling domain containing protein | 0.0053 | 0.0872 | 0.0821 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0872 | 0.0821 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0053 | 0.0872 | 0.5 |
Echinococcus granulosus | A kinase anchor protein 10 mitochondrial | 0.0053 | 0.0872 | 0.0914 |
Echinococcus multilocularis | regulator of G protein signaling 3 | 0.0053 | 0.0872 | 0.0914 |
Brugia malayi | hypothetical protein | 0.0053 | 0.0872 | 0.0821 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0872 | 0.0821 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0872 | 0.0821 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0053 | 0.0872 | 0.0914 |
Loa Loa (eye worm) | AGC/GRK/BARK protein kinase | 0.0055 | 0.0897 | 0.0845 |
Echinococcus multilocularis | regulator of G protein signaling 3 | 0.0053 | 0.0872 | 0.0914 |
Schistosoma mansoni | regulator of G protein signaling | 0.0053 | 0.0872 | 0.0821 |
Echinococcus granulosus | Regulator of G protein signaling 20 | 0.0053 | 0.0872 | 0.0914 |
Echinococcus granulosus | regulator of G protein signaling 3 | 0.0053 | 0.0872 | 0.0914 |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.0053 | 0.0872 | 0.0821 |
Brugia malayi | regulator of G-protein signaling rgs-7 | 0.0053 | 0.0872 | 0.0821 |
Schistosoma mansoni | regulator of G protein signaling 3 rgs3 | 0.0053 | 0.0872 | 0.0821 |
Schistosoma mansoni | z-protein (S1r protein) | 0.0053 | 0.0872 | 0.0821 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.