Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | A kinase anchor protein 10 mitochondrial | 0.021 | 0.0802 | 0.0893 |
Echinococcus multilocularis | regulator of G protein signaling 3 | 0.021 | 0.0802 | 0.0893 |
Trichomonas vaginalis | conserved hypothetical protein | 0.021 | 0.0802 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.021 | 0.0802 | 0.0802 |
Entamoeba histolytica | hypothetical protein | 0.021 | 0.0802 | 0.5 |
Echinococcus granulosus | [G-protein-coupledreceptor] kinase | 0.1899 | 0.8981 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.211 | 1 | 1 |
Echinococcus granulosus | axis inhibition protein axin | 0.021 | 0.0802 | 0.0893 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.211 | 1 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.0071 | 0.0079 |
Loa Loa (eye worm) | G protein-coupled receptor kinase 1 | 0.1899 | 0.8981 | 0.8981 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.1899 | 0.8981 | 0.8981 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0216 | 0.0827 | 0.0827 |
Brugia malayi | Probable G protein-coupled receptor kinase F19C6.1, putative | 0.1899 | 0.8981 | 0.8981 |
Echinococcus granulosus | beta-adrenergic receptor kinase | 0.0216 | 0.0827 | 0.0921 |
Trichomonas vaginalis | conserved hypothetical protein | 0.021 | 0.0802 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.021 | 0.0802 | 0.0802 |
Entamoeba histolytica | hypothetical protein | 0.021 | 0.0802 | 0.5 |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.021 | 0.0802 | 0.0802 |
Schistosoma mansoni | regulator of G protein signaling 3 rgs3 | 0.021 | 0.0802 | 0.0802 |
Trichomonas vaginalis | conserved hypothetical protein | 0.021 | 0.0802 | 0.5 |
Echinococcus granulosus | regulator of G protein signaling 3 | 0.021 | 0.0802 | 0.0893 |
Schistosoma mansoni | regulator of G protein signaling | 0.021 | 0.0802 | 0.0802 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.006 | 0.0071 | 0.5 |
Echinococcus granulosus | regulator of G protein signaling 3 | 0.021 | 0.0802 | 0.0893 |
Schistosoma mansoni | regulator of G protein signaling | 0.021 | 0.0802 | 0.0802 |
Trichomonas vaginalis | conserved hypothetical protein | 0.021 | 0.0802 | 0.5 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.021 | 0.0802 | 0.0802 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.0071 | 0.5 |
Schistosoma mansoni | regulator of G protein signaling | 0.021 | 0.0802 | 0.0802 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.0071 | 0.0079 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0057 | 0.0061 | 0.0068 |
Echinococcus multilocularis | axis inhibition protein axin | 0.021 | 0.0802 | 0.0893 |
Brugia malayi | A-kinase anchor protein 10, precursor | 0.021 | 0.0802 | 0.0802 |
Echinococcus multilocularis | G protein coupled receptor kinase 6 | 0.1899 | 0.8981 | 1 |
Echinococcus multilocularis | regulator of G protein signaling | 0.021 | 0.0802 | 0.0893 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.006 | 0.0071 | 0.5 |
Loa Loa (eye worm) | PXA domain-containing protein | 0.021 | 0.0802 | 0.0802 |
Brugia malayi | PXA domain containing protein | 0.021 | 0.0802 | 0.0802 |
Loa Loa (eye worm) | hypothetical protein | 0.021 | 0.0802 | 0.0802 |
Schistosoma mansoni | regulator of G protein signaling | 0.021 | 0.0802 | 0.0802 |
Echinococcus multilocularis | regulator of G protein signaling 3 | 0.021 | 0.0802 | 0.0893 |
Brugia malayi | regulator of G-protein signaling rgs-7 | 0.021 | 0.0802 | 0.0802 |
Echinococcus multilocularis | Regulator of G protein signaling 20 | 0.021 | 0.0802 | 0.0893 |
Schistosoma mansoni | lipoxygenase | 0.0057 | 0.0061 | 0.0061 |
Loa Loa (eye worm) | hypothetical protein | 0.021 | 0.0802 | 0.0802 |
Echinococcus multilocularis | beta adrenergic receptor kinase | 0.0216 | 0.0827 | 0.0921 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.0071 | 0.0071 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.006 | 0.0071 | 0.5 |
Schistosoma mansoni | axis inhibition protein axin | 0.021 | 0.0802 | 0.0802 |
Schistosoma mansoni | z-protein (S1r protein) | 0.021 | 0.0802 | 0.0802 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.021 | 0.0802 | 0.0893 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.0071 | 0.0071 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.0071 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.0071 | 0.5 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.021 | 0.0802 | 0.0893 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.021 | 0.0802 | 0.0802 |
Brugia malayi | Regulator of G protein signaling domain containing protein | 0.021 | 0.0802 | 0.0802 |
Brugia malayi | hypothetical protein | 0.021 | 0.0802 | 0.0802 |
Entamoeba histolytica | hypothetical protein | 0.021 | 0.0802 | 0.5 |
Brugia malayi | PXA domain containing protein | 0.021 | 0.0802 | 0.0802 |
Trichomonas vaginalis | conserved hypothetical protein | 0.021 | 0.0802 | 0.5 |
Brugia malayi | Regulator of G protein signaling domain containing protein | 0.021 | 0.0802 | 0.0802 |
Loa Loa (eye worm) | AGC/GRK/BARK protein kinase | 0.0216 | 0.0827 | 0.0827 |
Echinococcus multilocularis | axis inhibition protein axin | 0.021 | 0.0802 | 0.0893 |
Trichomonas vaginalis | regulator of G protein signaling 5, rgs5, putative | 0.021 | 0.0802 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.021 | 0.0802 | 0.5 |
Echinococcus granulosus | expressed protein | 0.021 | 0.0802 | 0.0893 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0216 | 0.0827 | 0.0827 |
Echinococcus granulosus | Regulator of G protein signaling 20 | 0.021 | 0.0802 | 0.0893 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.021 | 0.0802 | 0.0893 |
Schistosoma mansoni | regulator of G protein signaling | 0.021 | 0.0802 | 0.0802 |
Echinococcus multilocularis | expressed protein | 0.021 | 0.0802 | 0.0893 |
Brugia malayi | hypothetical protein | 0.021 | 0.0802 | 0.0802 |
Loa Loa (eye worm) | hypothetical protein | 0.021 | 0.0802 | 0.0802 |
Echinococcus multilocularis | A kinase anchor protein 10, mitochondrial | 0.021 | 0.0802 | 0.0893 |
Loa Loa (eye worm) | RGS-3 protein | 0.021 | 0.0802 | 0.0802 |
Echinococcus granulosus | axis inhibition protein axin | 0.021 | 0.0802 | 0.0893 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0057 | 0.0061 | 0.0068 |
Loa Loa (eye worm) | hypothetical protein | 0.021 | 0.0802 | 0.0802 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.021 | 0.0802 | 0.0893 |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.021 | 0.0802 | 0.0802 |
Schistosoma mansoni | axis inhibition protein axin | 0.021 | 0.0802 | 0.0802 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 88.08 uM | Growth inhibition of human HCT15 cells after 48 hrs by SRB assay | ChEMBL. | 24121236 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.