Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | IMP (inosine 5'-monophosphate) dehydrogenase 1 | Starlite/ChEMBL | References |
Homo sapiens | IMP (inosine 5'-monophosphate) dehydrogenase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.019 | 0.0945 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0499 | 0.3828 | 0.5 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.019 | 0.0945 | 0.2469 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0499 | 0.3828 | 0.5 |
Trypanosoma brucei | GMP reductase | 0.019 | 0.0945 | 0.2469 |
Echinococcus multilocularis | proto oncogene serine:threonine protein kinase | 0.1161 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, CK2 family | 0.0499 | 0.3828 | 1 |
Plasmodium falciparum | casein kinase 2, alpha subunit | 0.0499 | 0.3828 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0499 | 0.3828 | 0.5 |
Plasmodium vivax | unspecified product | 0.0499 | 0.3828 | 1 |
Echinococcus multilocularis | casein kinase ii subunit alpha | 0.0499 | 0.3828 | 0.3184 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0499 | 0.3828 | 0.5 |
Entamoeba histolytica | casein kinase, putative | 0.0499 | 0.3828 | 0.5 |
Plasmodium vivax | casein kinase 2, alpha subunit, putative | 0.0499 | 0.3828 | 1 |
Onchocerca volvulus | Serine\/threonine protein kinase homolog | 0.1161 | 1 | 1 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.01 | 0.0106 | 0.0954 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.019 | 0.0945 | 0.5 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.019 | 0.0945 | 1 |
Brugia malayi | Casein kinase II, alpha chain | 0.0499 | 0.3828 | 0.3184 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1161 | 1 | 1 |
Trypanosoma brucei | Casein kinase II | 0.0499 | 0.3828 | 1 |
Echinococcus granulosus | casein kinase ii subunit alpha | 0.0499 | 0.3828 | 0.3184 |
Leishmania major | casein kinase II, putative | 0.0499 | 0.3828 | 1 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.1161 | 1 | 1 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.019 | 0.0945 | 1 |
Trypanosoma cruzi | casein kinase II, putative | 0.0499 | 0.3828 | 1 |
Giardia lamblia | Kinase, CMGC CK2 | 0.0499 | 0.3828 | 0.5 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0178 | 0.084 | 0.8869 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0499 | 0.3828 | 0.5 |
Loa Loa (eye worm) | CMGC/CK2 protein kinase | 0.0499 | 0.3828 | 0.3184 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0499 | 0.3828 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0499 | 0.3828 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0499 | 0.3828 | 0.5 |
Schistosoma mansoni | protein kinase | 0.0499 | 0.3828 | 0.3184 |
Echinococcus granulosus | proto oncogene serine:threonine protein kinase | 0.1161 | 1 | 1 |
Loa Loa (eye worm) | CAMK/CAMKL/PASK protein kinase | 0.0707 | 0.5769 | 0.5328 |
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.1161 | 1 | 1 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.1161 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.01 uM | Antiproliferative activity against human PBMC assessed as incorporation of [3H]thymidine after 18 hrs by scintillation counting analysis | ChEMBL. | 24121309 |
EC50 (functional) | = 21.2 uM | Antiproliferative activity against human Jurkat cells assessed as incorporation of [3H]thymidine after 18 hrs by scintillation counting analysis | ChEMBL. | 24121309 |
IC50 (functional) | = 10 uM | Antiproliferative activity against human DU145 cells | ChEMBL. | 24269162 |
IC50 (functional) | > 100 uM | Antiproliferative activity against human PC3 cells | ChEMBL. | 24269162 |
Ki (binding) | = 2672 nM | Inhibition of IMPDH2 (unknown origin) | ChEMBL. | 24269162 |
Ki (binding) | = 4308 nM | Inhibition of IMPDH1 (unknown origin) | ChEMBL. | 24269162 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 24121309 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.