Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | IMP (inosine 5'-monophosphate) dehydrogenase 1 | Starlite/ChEMBL | References |
Homo sapiens | IMP (inosine 5'-monophosphate) dehydrogenase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.019 | 0.2797 | 1 |
Leishmania major | casein kinase II, putative | 0.0475 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, CK2 family | 0.0475 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0475 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.019 | 0.2797 | 1 |
Entamoeba histolytica | casein kinase, putative | 0.0475 | 1 | 0.5 |
Trypanosoma brucei | Casein kinase II | 0.0475 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0475 | 1 | 0.5 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0178 | 0.2513 | 0.8869 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0475 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0475 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0475 | 1 | 0.5 |
Plasmodium vivax | casein kinase 2, alpha subunit, putative | 0.0475 | 1 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0475 | 1 | 0.5 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.019 | 0.2797 | 1 |
Schistosoma mansoni | protein kinase | 0.0475 | 1 | 1 |
Onchocerca volvulus | 0.0411 | 0.8382 | 1 | |
Giardia lamblia | Kinase, CMGC CK2 | 0.0475 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.019 | 0.2797 | 0.5 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.01 | 0.0524 | 0.0954 |
Plasmodium falciparum | casein kinase 2, alpha subunit | 0.0475 | 1 | 1 |
Echinococcus multilocularis | casein kinase ii subunit alpha | 0.0475 | 1 | 1 |
Plasmodium vivax | unspecified product | 0.0475 | 1 | 1 |
Loa Loa (eye worm) | CMGC/CK2 protein kinase | 0.0475 | 1 | 1 |
Loa Loa (eye worm) | CAMK/CAMKL/PASK protein kinase | 0.0411 | 0.8382 | 0.8382 |
Echinococcus granulosus | casein kinase ii subunit alpha | 0.0475 | 1 | 1 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.019 | 0.2797 | 0.2797 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase family protein | 0.019 | 0.2797 | 0.2797 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0475 | 1 | 0.5 |
Trypanosoma cruzi | casein kinase II, putative | 0.0475 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0475 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.0014 uM | Antiproliferative activity against human PBMC assessed as incorporation of [3H]thymidine after 18 hrs by scintillation counting analysis | ChEMBL. | 24121309 |
EC50 (functional) | = 36.04 uM | Antiproliferative activity against human Jurkat cells assessed as incorporation of [3H]thymidine after 18 hrs by scintillation counting analysis | ChEMBL. | 24121309 |
IC50 (functional) | = 16 uM | Antiproliferative activity against human DU145 cells | ChEMBL. | 24269162 |
IC50 (functional) | = 61 uM | Antiproliferative activity against human PC3 cells | ChEMBL. | 24269162 |
Ki (binding) | = 1964 nM | Inhibition of IMPDH2 (unknown origin) | ChEMBL. | 24269162 |
Ki (binding) | = 7723 nM | Inhibition of IMPDH1 (unknown origin) | ChEMBL. | 24269162 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 24121309 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.