Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cyclin-dependent kinase 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | cyclin-dependent kinase 3 | 305 aa | 303 aa | 32.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0052 | 0.0451 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0052 | 0.0451 | 0.0458 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0052 | 0.0451 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.0451 | 0.5 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0052 | 0.0451 | 0.0458 |
Loa Loa (eye worm) | hypothetical protein | 0.0841 | 0.9838 | 0.9993 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0052 | 0.0451 | 1 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0052 | 0.0451 | 1 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0052 | 0.0451 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0841 | 0.9844 | 1 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0052 | 0.0451 | 0.0458 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0052 | 0.0451 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0052 | 0.0451 | 0.0451 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.0841 | 0.9844 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0841 | 0.9844 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0841 | 0.9838 | 0.9993 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0052 | 0.0451 | 1 |
Loa Loa (eye worm) | TKL/MLK/LZK protein kinase | 0.0841 | 0.9844 | 1 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0052 | 0.0451 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0052 | 0.0451 | 0.0458 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.0451 | 0.5 |
Giardia lamblia | Kinase, CMGC CDK | 0.0052 | 0.0451 | 0.5 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0052 | 0.0451 | 0.0458 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0052 | 0.0451 | 0.0007 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0052 | 0.0451 | 1 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0052 | 0.0451 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0052 | 0.0451 | 0.0007 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0052 | 0.0451 | 0.0458 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0052 | 0.0451 | 0.0451 |
Echinococcus granulosus | cyclin dependent kinase | 0.0052 | 0.0451 | 0.0458 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.0451 | 0.5 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0052 | 0.0451 | 0.0458 |
Plasmodium vivax | protein kinase Crk2 | 0.0052 | 0.0451 | 0.5 |
Plasmodium falciparum | protein kinase 5 | 0.0052 | 0.0451 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0052 | 0.0451 | 0.0007 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0052 | 0.0451 | 1 |
Giardia lamblia | Kinase, CMGC CDK | 0.0052 | 0.0451 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.042 uM | Inhibition of human N-terminal hexahistidine-tagged CDK2 expressed in baculovirus infected Sf21 cells using histone H1 as substrate after 10 mins in presence of [gamma-32P]-ATP | ChEMBL. | 23933045 |
IC50 (functional) | = 5.98 uM | Cytotoxicity against human MCF7 cells assessed as growth inhibition after 24 to 48 hrs by CCK8 assay | ChEMBL. | 23933045 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 23933045 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.