Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cyclin-dependent kinase 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | cyclin-dependent kinase 3 | 305 aa | 303 aa | 32.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0052 | 0.0149 | 0.0151 |
Giardia lamblia | Kinase, CMGC CDK | 0.0052 | 0.0149 | 0.5 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0052 | 0.0149 | 0.0151 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0052 | 0.0149 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0052 | 0.0149 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.1659 | 0.9838 | 0.9997 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.166 | 0.9841 | 1 |
Giardia lamblia | Kinase, CMGC CDK | 0.0052 | 0.0149 | 0.5 |
Loa Loa (eye worm) | TKL/MLK/LZK protein kinase | 0.166 | 0.9841 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0052 | 0.0149 | 0.0149 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.166 | 0.9841 | 1 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0052 | 0.0149 | 1 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0052 | 0.0149 | 1 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0052 | 0.0149 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.166 | 0.9841 | 1 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0052 | 0.0149 | 0.0151 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0052 | 0.0149 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1659 | 0.9838 | 0.9997 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0052 | 0.0149 | 0.0151 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0052 | 0.0149 | 0.0151 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0052 | 0.0149 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.0149 | 0.5 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0052 | 0.0149 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.0149 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0052 | 0.0149 | 1 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0052 | 0.0149 | 0.0151 |
Plasmodium falciparum | protein kinase 5 | 0.0052 | 0.0149 | 1 |
Plasmodium vivax | protein kinase Crk2 | 0.0052 | 0.0149 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0052 | 0.0149 | 0.5 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0052 | 0.0149 | 0.0151 |
Echinococcus granulosus | cyclin dependent kinase | 0.0052 | 0.0149 | 0.0151 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0052 | 0.0149 | 1 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0052 | 0.0149 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0052 | 0.0149 | 0.0003 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0052 | 0.0149 | 0.0149 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0052 | 0.0149 | 0.0003 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0052 | 0.0149 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.069 uM | Inhibition of human N-terminal hexahistidine-tagged CDK2 expressed in baculovirus infected Sf21 cells using histone H1 as substrate after 10 mins in presence of [gamma-32P]-ATP | ChEMBL. | 23933045 |
IC50 (functional) | = 5.9 uM | Cytotoxicity against human MCF7 cells assessed as growth inhibition after 24 to 48 hrs by CCK8 assay | ChEMBL. | 23933045 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 23933045 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.