Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.116 | 0.5675 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1966 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1966 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1127 | 0.5497 | 0.5497 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.1933 | 0.9822 | 0.9706 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0278 | 0.0937 | 0.0937 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0278 | 0.0937 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0278 | 0.0937 | 1 |
Onchocerca volvulus | 0.1966 | 1 | 1 | |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0192 | 0.0477 | 0.1027 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0278 | 0.0937 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0278 | 0.0937 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1933 | 0.9822 | 0.9822 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1966 | 1 | 1 |
Schistosoma mansoni | 6-phosphofructokinase | 0.1966 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0278 | 0.0937 | 1 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.1966 | 1 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.1933 | 0.9822 | 0.9706 |
Mycobacterium ulcerans | hypothetical protein | 0.116 | 0.5675 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1933 | 0.9822 | 0.9706 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.116 | 0.5675 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.116 | 0.5675 | 0.5 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0278 | 0.0937 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0192 | 0.0477 | 0.1027 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1966 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.1933 | 0.9822 | 0.9706 |
Giardia lamblia | Hypothetical protein | 0.116 | 0.5675 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1966 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0278 | 0.0937 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 3.2 mm | Antimicrobial activity against Escherichia coli ATCC 11230 at 25 ug/disk measured after overnight incubation by disk diffusion method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.