Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1966 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0192 | 0.0477 | 0.1027 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1966 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1966 | 1 | 1 |
Schistosoma mansoni | 6-phosphofructokinase | 0.1966 | 1 | 1 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.116 | 0.5675 | 0.5 |
Onchocerca volvulus | 0.1966 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.1127 | 0.5497 | 0.5497 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0278 | 0.0937 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0192 | 0.0477 | 0.1027 |
Loa Loa (eye worm) | hypothetical protein | 0.1966 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0278 | 0.0937 | 1 |
Giardia lamblia | Hypothetical protein | 0.116 | 0.5675 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0278 | 0.0937 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1933 | 0.9822 | 0.9706 |
Loa Loa (eye worm) | hypothetical protein | 0.1933 | 0.9822 | 0.9822 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1966 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0278 | 0.0937 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.1933 | 0.9822 | 0.9706 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0278 | 0.0937 | 1 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.1966 | 1 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.1933 | 0.9822 | 0.9706 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.116 | 0.5675 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.116 | 0.5675 | 0.5 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0278 | 0.0937 | 0.0937 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0278 | 0.0937 | 1 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0278 | 0.0937 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.116 | 0.5675 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.1933 | 0.9822 | 0.9706 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 3.2 mm | Antimicrobial activity against Escherichia coli ATCC 11230 at 25 ug/disk measured after overnight incubation by disk diffusion method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.