Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | regulator of G-protein signaling egl-10 | 0.0155 | 0.0717 | 0.0717 |
Brugia malayi | Regulator of G protein signaling domain containing protein | 0.0155 | 0.0717 | 0.0717 |
Echinococcus granulosus | [G-protein-coupledreceptor] kinase | 0.1401 | 0.8971 | 1 |
Loa Loa (eye worm) | AGC/GRK/BARK protein kinase | 0.0159 | 0.0742 | 0.0742 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.0717 | 0.0717 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.0717 | 0.0717 |
Schistosoma mansoni | regulator of G protein signaling | 0.0155 | 0.0717 | 0.0717 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.006 | 0.0088 | 0.0098 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.006 | 0.0088 | 0.0098 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.0155 | 0.0717 | 0.0717 |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.0155 | 0.0717 | 0.0717 |
Echinococcus granulosus | axis inhibition protein axin | 0.0155 | 0.0717 | 0.08 |
Brugia malayi | PXA domain containing protein | 0.0155 | 0.0717 | 0.0717 |
Loa Loa (eye worm) | PXA domain-containing protein | 0.0155 | 0.0717 | 0.0717 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0155 | 0.0717 | 0.08 |
Echinococcus granulosus | regulator of G protein signaling 3 | 0.0155 | 0.0717 | 0.08 |
Echinococcus multilocularis | A kinase anchor protein 10, mitochondrial | 0.0155 | 0.0717 | 0.08 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.1401 | 0.8971 | 0.8971 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0155 | 0.0717 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0155 | 0.0717 | 0.5 |
Echinococcus granulosus | beta-adrenergic receptor kinase | 0.0159 | 0.0742 | 0.0827 |
Echinococcus multilocularis | axis inhibition protein axin | 0.0155 | 0.0717 | 0.08 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1556 | 1 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0062 | 0.0102 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 0.0102 | 0.0102 |
Entamoeba histolytica | hypothetical protein | 0.0155 | 0.0717 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0155 | 0.0717 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0155 | 0.0717 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 0.0102 | 0.0102 |
Brugia malayi | Regulator of G protein signaling domain containing protein | 0.0155 | 0.0717 | 0.0717 |
Schistosoma mansoni | regulator of G protein signaling | 0.0155 | 0.0717 | 0.0717 |
Schistosoma mansoni | regulator of G protein signaling | 0.0155 | 0.0717 | 0.0717 |
Echinococcus multilocularis | regulator of G protein signaling 3 | 0.0155 | 0.0717 | 0.08 |
Entamoeba histolytica | hypothetical protein | 0.0155 | 0.0717 | 0.5 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0062 | 0.0102 | 0.0114 |
Schistosoma mansoni | z-protein (S1r protein) | 0.0155 | 0.0717 | 0.0717 |
Echinococcus multilocularis | axis inhibition protein axin | 0.0155 | 0.0717 | 0.08 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0062 | 0.0102 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.0717 | 0.0717 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0159 | 0.0742 | 0.0742 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.1556 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.0102 | 0.5 |
Brugia malayi | A-kinase anchor protein 10, precursor | 0.0155 | 0.0717 | 0.0717 |
Brugia malayi | PXA domain containing protein | 0.0155 | 0.0717 | 0.0717 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0155 | 0.0717 | 0.5 |
Brugia malayi | hypothetical protein | 0.0155 | 0.0717 | 0.0717 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.0717 | 0.0717 |
Trichomonas vaginalis | regulator of G protein signaling 5, rgs5, putative | 0.0155 | 0.0717 | 0.5 |
Echinococcus granulosus | regulator of G protein signaling 3 | 0.0155 | 0.0717 | 0.08 |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.0155 | 0.0717 | 0.0717 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0159 | 0.0742 | 0.0742 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.0102 | 0.5 |
Schistosoma mansoni | regulator of G protein signaling | 0.0155 | 0.0717 | 0.0717 |
Echinococcus granulosus | A kinase anchor protein 10 mitochondrial | 0.0155 | 0.0717 | 0.08 |
Schistosoma mansoni | regulator of G protein signaling 3 rgs3 | 0.0155 | 0.0717 | 0.0717 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0062 | 0.0102 | 0.0114 |
Echinococcus granulosus | axis inhibition protein axin | 0.0155 | 0.0717 | 0.08 |
Loa Loa (eye worm) | G protein-coupled receptor kinase 1 | 0.1401 | 0.8971 | 0.8971 |
Loa Loa (eye worm) | RGS-3 protein | 0.0155 | 0.0717 | 0.0717 |
Echinococcus multilocularis | G protein coupled receptor kinase 6 | 0.1401 | 0.8971 | 1 |
Echinococcus multilocularis | regulator of G protein signaling 3 | 0.0155 | 0.0717 | 0.08 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0155 | 0.0717 | 0.08 |
Brugia malayi | Probable G protein-coupled receptor kinase F19C6.1, putative | 0.1401 | 0.8971 | 0.8971 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0155 | 0.0717 | 0.08 |
Echinococcus multilocularis | beta adrenergic receptor kinase | 0.0159 | 0.0742 | 0.0827 |
Echinococcus granulosus | Regulator of G protein signaling 20 | 0.0155 | 0.0717 | 0.08 |
Brugia malayi | regulator of G-protein signaling rgs-7 | 0.0155 | 0.0717 | 0.0717 |
Schistosoma mansoni | axis inhibition protein axin | 0.0155 | 0.0717 | 0.0717 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.0102 | 0.5 |
Schistosoma mansoni | regulator of G protein signaling | 0.0155 | 0.0717 | 0.0717 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0155 | 0.0717 | 0.08 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.0717 | 0.0717 |
Brugia malayi | hypothetical protein | 0.0155 | 0.0717 | 0.0717 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0155 | 0.0717 | 0.5 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0062 | 0.0102 | 0.5 |
Echinococcus multilocularis | regulator of G protein signaling | 0.0155 | 0.0717 | 0.08 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.0717 | 0.0717 |
Echinococcus multilocularis | expressed protein | 0.0155 | 0.0717 | 0.08 |
Echinococcus granulosus | expressed protein | 0.0155 | 0.0717 | 0.08 |
Echinococcus multilocularis | Regulator of G protein signaling 20 | 0.0155 | 0.0717 | 0.08 |
Entamoeba histolytica | hypothetical protein | 0.0155 | 0.0717 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.006 | 0.0088 | 0.0088 |
Schistosoma mansoni | axis inhibition protein axin | 0.0155 | 0.0717 | 0.0717 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antifungal activity against Saccharomyces cerevisiae at 2 to 64 ug/ml after 7 days by agar well diffusion method | ChEMBL. | No reference | |
Activity (functional) | Antibacterial activity against Escherichia coli at 2 to 64 ug/ml after 24 hr by agar well diffusion method | ChEMBL. | No reference | |
IZ (functional) | = 11 mm | Antifungal activity against Candida albicans at 2 to 64 ug/ml after 7 days by agar well diffusion method | ChEMBL. | No reference |
MIC (functional) | Antibacterial activity against Escherichia coli after 24 hr by agar well diffusion method | ChEMBL. | No reference | |
MIC (functional) | Antifungal activity against Saccharomyces cerevisiae after 7 days by agar well diffusion method | ChEMBL. | No reference | |
MIC (functional) | = 2 ug ml-1 | Antifungal activity against Candida albicans after 7 days by agar well diffusion method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.