Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | G protein-coupled receptor kinase 1 | 0.1656 | 0.8977 | 0.8977 |
Echinococcus multilocularis | G protein coupled receptor kinase 6 | 0.1656 | 0.8977 | 1 |
Loa Loa (eye worm) | RGS-3 protein | 0.0184 | 0.0766 | 0.0766 |
Echinococcus granulosus | axis inhibition protein axin | 0.0184 | 0.0766 | 0.0853 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0061 | 0.0084 | 0.0094 |
Schistosoma mansoni | regulator of G protein signaling 3 rgs3 | 0.0184 | 0.0766 | 0.0766 |
Echinococcus granulosus | A kinase anchor protein 10 mitochondrial | 0.0184 | 0.0766 | 0.0853 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.0084 | 0.5 |
Schistosoma mansoni | axis inhibition protein axin | 0.0184 | 0.0766 | 0.0766 |
Brugia malayi | regulator of G-protein signaling rgs-7 | 0.0184 | 0.0766 | 0.0766 |
Schistosoma mansoni | regulator of G protein signaling | 0.0184 | 0.0766 | 0.0766 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0184 | 0.0766 | 0.0853 |
Echinococcus multilocularis | regulator of G protein signaling 3 | 0.0184 | 0.0766 | 0.0853 |
Echinococcus granulosus | Regulator of G protein signaling 20 | 0.0184 | 0.0766 | 0.0853 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0184 | 0.0766 | 0.0853 |
Brugia malayi | Probable G protein-coupled receptor kinase F19C6.1, putative | 0.1656 | 0.8977 | 0.8977 |
Echinococcus multilocularis | beta adrenergic receptor kinase | 0.0188 | 0.079 | 0.0881 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0061 | 0.0084 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0184 | 0.0766 | 0.5 |
Echinococcus multilocularis | regulator of G protein signaling | 0.0184 | 0.0766 | 0.0853 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.0766 | 0.0766 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0184 | 0.0766 | 0.0853 |
Brugia malayi | hypothetical protein | 0.0184 | 0.0766 | 0.0766 |
Echinococcus multilocularis | Regulator of G protein signaling 20 | 0.0184 | 0.0766 | 0.0853 |
Schistosoma mansoni | axis inhibition protein axin | 0.0184 | 0.0766 | 0.0766 |
Entamoeba histolytica | hypothetical protein | 0.0184 | 0.0766 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0059 | 0.0072 | 0.0072 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.0766 | 0.0766 |
Echinococcus granulosus | expressed protein | 0.0184 | 0.0766 | 0.0853 |
Echinococcus multilocularis | expressed protein | 0.0184 | 0.0766 | 0.0853 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0059 | 0.0072 | 0.008 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0059 | 0.0072 | 0.008 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.0766 | 0.0766 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.0766 | 0.0766 |
Schistosoma mansoni | regulator of G protein signaling | 0.0184 | 0.0766 | 0.0766 |
Brugia malayi | PXA domain containing protein | 0.0184 | 0.0766 | 0.0766 |
Echinococcus granulosus | axis inhibition protein axin | 0.0184 | 0.0766 | 0.0853 |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.0184 | 0.0766 | 0.0766 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.0184 | 0.0766 | 0.0766 |
Brugia malayi | Regulator of G protein signaling domain containing protein | 0.0184 | 0.0766 | 0.0766 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.0184 | 0.0766 | 0.0766 |
Loa Loa (eye worm) | AGC/GRK/BARK protein kinase | 0.0188 | 0.079 | 0.079 |
Echinococcus granulosus | [G-protein-coupledreceptor] kinase | 0.1656 | 0.8977 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.184 | 1 | 1 |
Echinococcus multilocularis | axis inhibition protein axin | 0.0184 | 0.0766 | 0.0853 |
Echinococcus granulosus | beta-adrenergic receptor kinase | 0.0188 | 0.079 | 0.0881 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0061 | 0.0084 | 0.5 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0184 | 0.0766 | 0.0853 |
Loa Loa (eye worm) | PXA domain-containing protein | 0.0184 | 0.0766 | 0.0766 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0184 | 0.0766 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0184 | 0.0766 | 0.5 |
Echinococcus multilocularis | A kinase anchor protein 10, mitochondrial | 0.0184 | 0.0766 | 0.0853 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.1656 | 0.8977 | 0.8977 |
Echinococcus granulosus | regulator of G protein signaling 3 | 0.0184 | 0.0766 | 0.0853 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.0766 | 0.0766 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0061 | 0.0084 | 0.5 |
Echinococcus multilocularis | axis inhibition protein axin | 0.0184 | 0.0766 | 0.0853 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.184 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0188 | 0.079 | 0.079 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0061 | 0.0084 | 0.0084 |
Brugia malayi | Regulator of G protein signaling domain containing protein | 0.0184 | 0.0766 | 0.0766 |
Schistosoma mansoni | regulator of G protein signaling | 0.0184 | 0.0766 | 0.0766 |
Schistosoma mansoni | regulator of G protein signaling | 0.0184 | 0.0766 | 0.0766 |
Entamoeba histolytica | hypothetical protein | 0.0184 | 0.0766 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0184 | 0.0766 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0184 | 0.0766 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0061 | 0.0084 | 0.0084 |
Schistosoma mansoni | z-protein (S1r protein) | 0.0184 | 0.0766 | 0.0766 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0061 | 0.0084 | 0.0094 |
Echinococcus multilocularis | regulator of G protein signaling 3 | 0.0184 | 0.0766 | 0.0853 |
Entamoeba histolytica | hypothetical protein | 0.0184 | 0.0766 | 0.5 |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.0184 | 0.0766 | 0.0766 |
Echinococcus granulosus | regulator of G protein signaling 3 | 0.0184 | 0.0766 | 0.0853 |
Trichomonas vaginalis | regulator of G protein signaling 5, rgs5, putative | 0.0184 | 0.0766 | 0.5 |
Schistosoma mansoni | regulator of G protein signaling | 0.0184 | 0.0766 | 0.0766 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.0084 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0188 | 0.079 | 0.079 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0184 | 0.0766 | 0.5 |
Brugia malayi | PXA domain containing protein | 0.0184 | 0.0766 | 0.0766 |
Brugia malayi | A-kinase anchor protein 10, precursor | 0.0184 | 0.0766 | 0.0766 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.0084 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.0766 | 0.0766 |
Brugia malayi | hypothetical protein | 0.0184 | 0.0766 | 0.0766 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antibacterial activity against Escherichia coli at 2 to 64 ug/ml after 24 hr by agar well diffusion method | ChEMBL. | No reference | |
Activity (functional) | Antifungal activity against Candida albicans at 2 to 64 ug/ml after 7 days by agar well diffusion method | ChEMBL. | No reference | |
Activity (functional) | Antifungal activity against Saccharomyces cerevisiae at 2 to 64 ug/ml after 7 days by agar well diffusion method | ChEMBL. | No reference | |
MIC (functional) | Antifungal activity against Saccharomyces cerevisiae after 7 days by agar well diffusion method | ChEMBL. | No reference | |
MIC (functional) | Antibacterial activity against Escherichia coli after 24 hr by agar well diffusion method | ChEMBL. | No reference | |
MIC (functional) | Antifungal activity against Candida albicans after 7 days by agar well diffusion method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.