TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 578.971 | Formula: C26H26ClF3N6O4
H donors: 1 H acceptors: 4 LogP: 4.97 Rotable bonds: 9
Rule of 5 violations (Lipinski): 2
SMILES: O=C(N1CCN(CC1)c1ccc(cn1)NC(=O)c1oc(nc1C(F)(F)F)N1CCCCC1)Oc1ccccc1Cl
InChi: 1S/C26H26ClF3N6O4/c27-18-6-2-3-7-19(18)39-25(38)36-14-12-34(13-15-36)20-9-8-17(16-31-20)32-23(37)21-22(26(28,29)30)33-24(40-21)35-10-4-1-5-11-35/h2-3,6-9,16H,1,4-5,10-15H2,(H,32,37)
InChiKey: SFHFXDWEZMBYQZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mus musculus	diacylglycerol O-acyltransferase 1	Starlite/ChEMBL	References
Homo sapiens	diacylglycerol O-acyltransferase 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Toxoplasma gondii	acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha	Get druggable targets OG5_128200	All targets in OG5_128200
Candida albicans	Acyl-CoA cholesterol acyltransferase	Get druggable targets OG5_128200	All targets in OG5_128200
Schistosoma mansoni	diacylglycerol O-acyltransferase 1	Get druggable targets OG5_128200	All targets in OG5_128200
Theileria parva	diacylglycerol O-acyltransferase, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Neospora caninum	diacylglycerol acyltransferase, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Babesia bovis	diacylglycerol acyltransferase, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Neospora caninum	sterol O-acyltransferase, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Plasmodium falciparum	diacylglycerol O-acyltransferase	Get druggable targets OG5_128200	All targets in OG5_128200
Toxoplasma gondii	acyl-CoA:diacylglycerol acyltransferase 1-related enzyme	Get druggable targets OG5_128200	All targets in OG5_128200
Schistosoma japonicum	Diacylglycerol O-acyltransferase 1, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Cryptosporidium hominis	acyl-CoA:diacylglycerol acyltransferase 1-related enzyme	Get druggable targets OG5_128200	All targets in OG5_128200
Plasmodium yoelii	acyl transferase-related	Get druggable targets OG5_128200	All targets in OG5_128200
Echinococcus granulosus	diacylglycerol O acyltransferase 1	Get druggable targets OG5_128200	All targets in OG5_128200
Plasmodium vivax	diacylglycerol O-acyltransferase, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Schistosoma japonicum	Diacylglycerol O-acyltransferase 1, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Loa Loa (eye worm)	diacylglycerol acyltransferase	Get druggable targets OG5_128200	All targets in OG5_128200
Plasmodium knowlesi	diacylglycerol O-acyltransferase, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128200	All targets in OG5_128200
Plasmodium berghei	diacylglycerol O-acyltransferase, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Brugia malayi	diacylglycerol acyltransferase	Get druggable targets OG5_128200	All targets in OG5_128200
Schistosoma japonicum	ko:K00635 diacylglycerol O-acyltransferase [EC2.3.1.20], putative	Get druggable targets OG5_128200	All targets in OG5_128200
Echinococcus multilocularis	diacylglycerol O acyltransferase 1	Get druggable targets OG5_128200	All targets in OG5_128200
Candida albicans	Acyl-CoA cholesterol acyltransferase	Get druggable targets OG5_128200	All targets in OG5_128200
Cryptosporidium parvum	diacylglycerol acyltransferase 1	Get druggable targets OG5_128200	All targets in OG5_128200

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	diacylglycerol O acyltransferase 1	0.0307	0.0556	0.0565
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0069	0	0.5
Trypanosoma cruzi	protein kinase, putative	0.0069	0	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.0069	0	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0069	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0069	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0069	0	0.5
Trypanosoma brucei	protein kinase, putative	0.0069	0	0.5
Brugia malayi	Hemopexin family protein	0.1182	0.2605	0.2648
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0135	0.0153	0.0153
Entamoeba histolytica	protein kinase domain containing protein	0.0069	0	0.5
Giardia lamblia	Protein 21.1	0.0069	0	0.5
Echinococcus multilocularis	matrix metallopeptidase 7 (M10 family)	0.3076	0.7041	0.7157
Entamoeba histolytica	protein kinase, putative	0.0069	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0069	0	0.5
Schistosoma mansoni	matrix metallopeptidase-9 (M10 family)	0.1149	0.2528	0.2528
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0	0.5
Echinococcus multilocularis	endothelin converting enzyme 1	0.0135	0.0153	0.0156
Trichomonas vaginalis	TK family protein kinase	0.0069	0	0.5
Leishmania major	protein kinase, putative	0.0069	0	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0069	0	0.5
Schistosoma mansoni	matrix metallopeptidase-7 (M10 family)	0.0854	0.1838	0.1838
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Toxoplasma gondii	acyl-CoA:diacylglycerol acyltransferase 1-related enzyme	0.0307	0.0556	1
Entamoeba histolytica	ankyrin repeat protein	0.0069	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Trichomonas vaginalis	STE family protein kinase	0.0069	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0069	0	0.5
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0069	0	0.5
Entamoeba histolytica	hypothetical protein	0.0069	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Brugia malayi	Matrixin family protein	0.0854	0.1838	0.1868
Toxoplasma gondii	peptidase family M13 protein	0.0135	0.0153	0.2758
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Entamoeba histolytica	hypothetical protein	0.0069	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0069	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0069	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0069	0	0.5
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0069	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0069	0	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0069	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0069	0	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0069	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0069	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0255	0.0435	0.0443
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.4271	0.9838	1
Schistosoma mansoni	diacylglycerol O-acyltransferase 1	0.0307	0.0556	0.0556
Toxoplasma gondii	acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha	0.0307	0.0556	1
Brugia malayi	Matrixin family protein	0.0854	0.1838	0.1868
Brugia malayi	Angiotensin-converting enzyme family protein	0.0442	0.0873	0.0888
Loa Loa (eye worm)	hypothetical protein	0.4271	0.9838	1
Onchocerca volvulus	Matrilysin homolog	0.0854	0.1838	0.43
Entamoeba histolytica	ankyrin repeat protein	0.0069	0	0.5
Entamoeba histolytica	hypothetical protein	0.0069	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0069	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.4271	0.9838	1
Loa Loa (eye worm)	peptidase family M13 containing protein	0.01	0.0071	0.0072
Loa Loa (eye worm)	TKL/MLK/LZK protein kinase	0.4271	0.9838	1
Entamoeba histolytica	tyrosine kinase, putative	0.0069	0	0.5
Echinococcus granulosus	matrix metallopeptidase 7 M10 family	0.3076	0.7041	0.7157
Onchocerca volvulus		0.1182	0.2605	0.6095
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0069	0	0.5
Brugia malayi	Matrixin family protein	0.2036	0.4605	0.4681
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0069	0	0.5
Entamoeba histolytica	receptor protein kinase, putative	0.0069	0	0.5
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0069	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0069	0	0.5
Entamoeba histolytica	hypothetical protein	0.0069	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0069	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0069	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0069	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0069	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0069	0	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.0069	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Entamoeba histolytica	hypothetical protein	0.0069	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0069	0	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0069	0	0.5
Trichomonas vaginalis	protein kinase atn1, putative	0.0069	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Brugia malayi	Matrixin family protein	0.0854	0.1838	0.1868
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0069	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.104	0.2274	0.2311
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0153	0.0156
Entamoeba histolytica	protein kinase domain containing protein	0.0069	0	0.5
Loa Loa (eye worm)	peptidase family M13 containing protein	0.01	0.0071	0.0072
Echinococcus granulosus	diacylglycerol O acyltransferase 1	0.0307	0.0556	0.0565
Mycobacterium tuberculosis	Probable peptidoglycan hydrolase	0.104	0.2274	1
Entamoeba histolytica	tyrosine kinase, putative	0.0069	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0069	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Brugia malayi	diacylglycerol acyltransferase	0.0307	0.0556	0.0565
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0077	0.0078
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0069	0	0.5
Entamoeba histolytica	hypothetical protein	0.0069	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.4271	0.9838	1
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0077	0.0078
Loa Loa (eye worm)	hypothetical protein	0.01	0.0071	0.0072
Loa Loa (eye worm)	hypothetical protein	0.01	0.0071	0.0072
Entamoeba histolytica	protein kinase domain containing protein	0.0069	0	0.5
Entamoeba histolytica	hypothetical protein, conserved	0.0069	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0069	0	0.5
Loa Loa (eye worm)	angiotensin-converting enzyme family protein	0.0442	0.0873	0.0888
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0069	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0854	0.1838	0.1868
Entamoeba histolytica	protein kinase, putative	0.0069	0	0.5
Giardia lamblia	Kinase	0.0069	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0069	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0069	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0069	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0069	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0069	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0069	0	0.5
Leishmania major	protein kinase, putative	0.0069	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0069	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0069	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0077	0.0078
Entamoeba histolytica	serine/threonine kinase, putative	0.0069	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0854	0.1838	0.1868
Entamoeba histolytica	protein kinase, putative	0.0069	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0153	0.0156
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Entamoeba histolytica	hypothetical protein	0.0069	0	0.5
Brugia malayi	Peptidase family M13 containing protein	0.0135	0.0153	0.0156
Entamoeba histolytica	tyrosin kinase, putative	0.0069	0	0.5
Entamoeba histolytica	cysteine surface protein, putative	0.0069	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Entamoeba histolytica	hypothetical protein	0.0069	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0069	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0069	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0069	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0069	0	0.5
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0069	0	0.5
Loa Loa (eye worm)	matrixin family protein	0.1894	0.4274	0.4344
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0069	0	0.5
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0069	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Entamoeba histolytica	hypothetical protein	0.0069	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0	0.5
Plasmodium falciparum	diacylglycerol O-acyltransferase	0.0307	0.0556	1
Entamoeba histolytica	tyrosine kinase, putative	0.0069	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Loa Loa (eye worm)	diacylglycerol acyltransferase	0.0307	0.0556	0.0565
Entamoeba histolytica	protein kinase domain containing protein	0.0069	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0069	0	0.5
Onchocerca volvulus	Matrilysin homolog	0.1894	0.4274	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0069	0	0.5
Entamoeba histolytica	receptor protein kinase, putative	0.0069	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0	0.5
Brugia malayi	Matrixin family protein	0.0854	0.1838	0.1868
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Schistosoma mansoni	hypothetical protein	0.1182	0.2605	0.2605
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Onchocerca volvulus		0.0854	0.1838	0.43
Entamoeba histolytica	tyrosine kinase, putative	0.0069	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0077	0.0078
Onchocerca volvulus	Matrix metalloproteinase homolog	0.1894	0.4274	1
Entamoeba histolytica	protein kinase domain containing protein	0.0069	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0069	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0069	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0077	0.0078
Entamoeba histolytica	protein kinase, putative	0.0069	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0069	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0069	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0069	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.01	0.0071	0.0072
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0069	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0069	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0069	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0077	0.0078
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0069	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0069	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0854	0.1838	0.1868
Entamoeba histolytica	tyrosine kinase, putative	0.0069	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0069	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0069	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0153	0.0156
Entamoeba histolytica	tyrosin kinase, putative	0.0069	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0069	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0069	0	0.5
Entamoeba histolytica	hypothetical protein	0.0069	0	0.5
Trypanosoma brucei	Pseudokinase, putative	0.0069	0	0.5
Brugia malayi	Hypothetical zinc metalloproteinase T16A9.4	0.0135	0.0153	0.0156
Mycobacterium ulcerans	hydrolase	0.104	0.2274	1
Mycobacterium leprae	PROBABLE HYDROLASE	0.104	0.2274	1
Loa Loa (eye worm)	matrixin family protein	0.2036	0.4605	0.4681
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0069	0	0.5
Leishmania major	hypothetical protein, conserved	0.0069	0	0.5
Loa Loa (eye worm)	matrix metalloproteinase	0.0854	0.1838	0.1868
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Echinococcus granulosus	endothelin converting enzyme 1	0.0135	0.0153	0.0156
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Brugia malayi	Matrix metalloprotease, N-terminal domain containing protein	0.104	0.2274	0.2311
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.4271	0.9838	1
Entamoeba histolytica	protein kinase, putative	0.0069	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0069	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0069	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0069	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0069	0	0.5
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0069	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0069	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.01	0.0071	0.0072
Trypanosoma cruzi	protein kinase, putative	0.0069	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0069	0	0.5
Giardia lamblia	Kinase, NEK	0.0069	0	0.5
Entamoeba histolytica	hypothetical protein	0.0069	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0069	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0069	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Giardia lamblia	Kinase, NEK	0.0069	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0069	0	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0069	0	0.5
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0069	0	0.5
Plasmodium vivax	diacylglycerol O-acyltransferase, putative	0.0307	0.0556	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 631 nM	Inhibition of human DGAT-1 expressed in insect Sf9 cell microsomes using 1,2-dioleoyl-sn-glycerol and [14C]-palmitoyl-CoA as substrate after 2 hrs	ChEMBL.	24120540
IC50 (binding)	= 1387 nM	Inhibition of mouse DGAT-1	ChEMBL.	24120540

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2441202

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1790226