Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | quinoid dihydropteridine reductase | Starlite/ChEMBL | References |
Rattus norvegicus | Dihydropteridine reductase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Dihydropteridine reductase | 241 aa | 229 aa | 24.9 % | |
Mycobacterium tuberculosis | Probable short-chain type oxidoreductase | quinoid dihydropteridine reductase | 244 aa | 248 aa | 25.4 % |
Loa Loa (eye worm) | hypothetical protein | Dihydropteridine reductase | 241 aa | 216 aa | 25.0 % |
Drosophila melanogaster | CG4842 gene product from transcript CG4842-RA | Dihydropteridine reductase | 241 aa | 203 aa | 22.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | quinonoid dihydropteridine reductase | 0.0202 | 0.4841 | 1 |
Toxoplasma gondii | 6,7-dihydropteridine reductase | 0.0192 | 0.458 | 1 |
Loa Loa (eye worm) | dihydropteridine reductase-PC | 0.0192 | 0.458 | 1 |
Schistosoma mansoni | dihydropteridine reductase | 0.0192 | 0.458 | 1 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0056 | 0.0776 | 0.0303 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0776 | 0.1693 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0052 | 0.0657 | 0.1434 |
Leishmania major | quinonoid dihydropteridine reductase | 0.0202 | 0.4841 | 1 |
Leishmania major | quinonoid dihydropteridine reductase | 0.0202 | 0.4841 | 1 |
Leishmania major | quinonoid dihydropteridine reductase | 0.0202 | 0.4841 | 1 |
Leishmania major | quinonoid dihydropteridine reductase | 0.0202 | 0.4841 | 1 |
Echinococcus granulosus | NADP binding domain | 0.0192 | 0.458 | 0.4199 |
Echinococcus multilocularis | tumor protein p63 | 0.0386 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0 | 0.5 |
Trypanosoma cruzi | quinonoid dihydropteridine reductase, putative | 0.0202 | 0.4841 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0029 | 0 | 0.5 |
Leishmania major | quinonoid dihydropteridine reductase | 0.0202 | 0.4841 | 1 |
Onchocerca volvulus | 0.0056 | 0.0776 | 0.5 | |
Leishmania major | quinonoid dihydropteridine reductase | 0.0202 | 0.4841 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0029 | 0 | 0.5 |
Brugia malayi | dihydropteridine reductase-like | 0.0192 | 0.458 | 1 |
Echinococcus multilocularis | NAD(P) binding domain | 0.0192 | 0.458 | 0.4199 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0052 | 0.0657 | 0.1434 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
I50 (binding) | = 0.00000025 M | Inhibitory activity against rat striatal synaptosomes Dihydrodipicolinate reductase | ChEMBL. | 3871859 |
I50 (binding) | = 0.00000028 M | Inhibitory activity against human liver Dihydrodipicolinate reductase | ChEMBL. | 3871859 |
IC50 (binding) | = 0.00000025 M | Inhibitory activity against rat striatal synaptosomes Dihydrodipicolinate reductase | ChEMBL. | 3871859 |
IC50 (binding) | = 0.00000028 M | Inhibitory activity against human liver Dihydrodipicolinate reductase | ChEMBL. | 3871859 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.