Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase (Yt blood group) | 614 aa | 510 aa | 26.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0427 | 0.0841 | 0.096 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.1508 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1362 | 0.8764 | 1 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0328 | 0 | 0.5 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0328 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0328 | 0 | 0.5 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0328 | 0 | 0.5 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.1263 | 0.7922 | 1 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0328 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1263 | 0.7922 | 0.904 |
Loa Loa (eye worm) | hypothetical protein | 0.0427 | 0.0841 | 0.096 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0328 | 0 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0328 | 0 | 0.5 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0328 | 0 | 0.5 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0328 | 0 | 0.5 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0328 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.118 | 0.7222 | 1 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.1263 | 0.7922 | 1 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0328 | 0 | 0.5 |
Leishmania major | UDP-galactopyranose mutase | 0.0328 | 0 | 0.5 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0328 | 0 | 0.5 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.1263 | 0.7922 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0328 | 0 | 0.5 |
Onchocerca volvulus | 0.1362 | 0.8764 | 0.5 | |
Brugia malayi | SWIRM domain containing protein | 0.1362 | 0.8764 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1263 | 0.7922 | 0.904 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.049 uM | Reversible inhibition of human recombinant AChE using acetylthiocholine iodide as substrate measured at initial time point by Ellmans method | ChEMBL. | 24076173 |
IC50 (binding) | = 0.11 uM | Reversible inhibition of human recombinant AChE using acetylthiocholine iodide as substrate measured after 2 hrs by Ellmans method | ChEMBL. | 24076173 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.