Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PROBABLE AMIDASE AMIC (AMINOHYDROLASE) | 0.0038 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0157 | 0.2068 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0318 | 0.4884 | 0.4884 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0157 | 0.2068 | 1 |
Onchocerca volvulus | 0.0611 | 1 | 0.5 | |
Schistosoma mansoni | amidase | 0.0318 | 0.4884 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0318 | 0.4884 | 0.4884 |
Loa Loa (eye worm) | lipase | 0.0611 | 1 | 1 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0318 | 0.4884 | 1 |
Trypanosoma brucei | lipase domain protein, putative | 0.0611 | 1 | 1 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0611 | 1 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0318 | 0.4884 | 0.4884 |
Plasmodium vivax | glutamyl-tRNA(Gln) amidotransferase subunit A, putative | 0.0038 | 0 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0611 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) | 0.0038 | 0 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0611 | 1 | 0.5 |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0038 | 0 | 0.5 |
Plasmodium falciparum | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0038 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0611 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0038 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0611 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0318 | 0.4884 | 0.4884 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0611 | 1 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0318 | 0.4884 | 0.4884 |
Brugia malayi | amidase | 0.0318 | 0.4884 | 0.4884 |
Trypanosoma brucei | lipase domain protein, putative | 0.0611 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0611 | 1 | 1 |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0038 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | > 100 uM | Cytotoxicity against Homo sapiens (human) MRC5 cells assessed as inhibition of cell viability by MTT assay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.