TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 324.417 | Formula: C20H24N2O2
H donors: 0 H acceptors: 2 LogP: 4.29 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: CCCCCCC(=O)Oc1ccc(cc1)/C=N/Cc1cccnc1
InChi: 1S/C20H24N2O2/c1-2-3-4-5-8-20(23)24-19-11-9-17(10-12-19)14-22-16-18-7-6-13-21-15-18/h6-7,9-15H,2-5,8,16H2,1H3/b22-14+
InChiKey: CEVOPTJUUNNMPV-HYARGMPZSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0054	0.0039	0.0039
Trichomonas vaginalis	intestinal guanylate cyclase, putative	0.018	0.0448	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.0039	0.0038
Echinococcus multilocularis	neuropeptides capa receptor	0.0054	0.0039	0.0039
Trichomonas vaginalis	adenylate cyclase type IX, putative	0.018	0.0448	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0054	0.0039	0.0039
Schistosoma mansoni	growth hormone secretagogue receptor	0.0054	0.0039	0.0038
Echinococcus granulosus	tm gpcr rhodopsin	0.0054	0.0039	0.0039
Echinococcus multilocularis	allatostatin A receptor	0.0054	0.0039	0.0039
Trichomonas vaginalis	guanylate cyclase, putative	0.018	0.0448	0.5
Echinococcus granulosus	neuropeptide Y receptor	0.0054	0.0039	0.0039
Mycobacterium leprae	Possible transporter protein	0.018	0.0448	0.5
Schistosoma mansoni	adenoreceptor	0.0054	0.0039	0.0038
Echinococcus granulosus	biogenic amine 5HT receptor	0.0054	0.0039	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0051
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0054	0.0039	0.0038
Brugia malayi	hypothetical protein	0.0054	0.0039	0.0856
Echinococcus multilocularis	p2X purinoceptor 4	0.3123	1	1
Echinococcus multilocularis	serotonin receptor	0.0054	0.0039	0.0039
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.018	0.0448	0.5
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.018	0.0448	0.5
Trichomonas vaginalis	guanylate cyclase, putative	0.018	0.0448	0.5
Brugia malayi	RNA binding protein	0.0068	0.0085	0.1898
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0051
Trichomonas vaginalis	adenylate cyclase, putative	0.018	0.0448	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.018	0.0448	0.5
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0051
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.0039	0.0038
Trichomonas vaginalis	adenylate cyclase, putative	0.018	0.0448	0.5
Loa Loa (eye worm)	hypothetical protein	0.018	0.0448	0.077
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0054	0.0039	0.0038
Echinococcus granulosus	single minded 2	0.018	0.0448	0.0448
Trichomonas vaginalis	adenylyl cyclase type V, putative	0.018	0.0448	0.5
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.018	0.0448	0.5
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0051
Trichomonas vaginalis	guanylate cyclase, putative	0.018	0.0448	0.5
Schistosoma mansoni	amine GPCR	0.0054	0.0039	0.0038
Echinococcus granulosus	neuropeptide FF receptor 2	0.0054	0.0039	0.0039
Trichomonas vaginalis	adenylate cyclase, putative	0.018	0.0448	0.5
Trichomonas vaginalis	adenylate cyclase type IX, putative	0.018	0.0448	0.5
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0051
Brugia malayi	hypothetical protein	0.0054	0.0039	0.0856
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0051
Schistosoma mansoni	opsin-like receptor	0.0054	0.0039	0.0038
Schistosoma mansoni	amine GPCR	0.0054	0.0039	0.0038
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0054	0.0039	0.0039
Trichomonas vaginalis	adenylate cyclase type, putative	0.018	0.0448	0.5
Echinococcus granulosus	neuropeptide Y receptor	0.0054	0.0039	0.0039
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0054	0.0039	0.0039
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0054	0.0039	0.0038
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0054	0.0039	0.0039
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0054	0.0039	0.0039
Echinococcus granulosus	somatostatin receptor	0.0054	0.0039	0.0039
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0054	0.0039	0.0856
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0051
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0068	0.0085	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0051
Echinococcus granulosus	7tm_1 domain containing protein	0.0054	0.0039	0.0039
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.0039	0.0038
Echinococcus granulosus	rhodopsin orphan GPCR	0.0054	0.0039	0.0039
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0054	0.0039	0.0039
Schistosoma mansoni	amine GPCR	0.0054	0.0039	0.0038
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.0039	0.0038
Echinococcus multilocularis	g protein coupled receptor	0.0054	0.0039	0.0039
Brugia malayi	GnHR receptor homolog	0.0054	0.0039	0.0856
Schistosoma mansoni	hypothetical protein	0.0054	0.0039	0.0038
Schistosoma mansoni	P2X receptor subunit	0.3123	1	1
Echinococcus granulosus	serotonin receptor	0.0054	0.0039	0.0039
Schistosoma mansoni	P2X receptor subunit	0.2822	0.9022	0.9022
Schistosoma mansoni	P2X receptor subunit	0.3123	1	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0054	0.0039	0.0038
Trichomonas vaginalis	guanylate cyclase, putative	0.018	0.0448	0.5
Trypanosoma brucei	STE group serine/threonine-protein kinase, putative	0.0193	0.0488	0.5
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0051
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0054	0.0039	0.0039
Echinococcus granulosus	sex peptide receptor	0.0054	0.0039	0.0039
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0054	0.0039	0.0038
Schistosoma mansoni	P2X receptor subunit	0.2822	0.9022	0.9022
Schistosoma mansoni	60S ribosomal protein L21	0.018	0.0448	0.0448
Echinococcus granulosus	biogenic amine 5HT receptor	0.0054	0.0039	0.0039
Schistosoma mansoni	amine GPCR	0.0054	0.0039	0.0038
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0054	0.0039	0.0038
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0054	0.0039	0.0039
Schistosoma mansoni	voltage-gated potassium channel	0.018	0.0448	0.0448
Echinococcus multilocularis	p2X purinoceptor 4	0.3123	1	1
Trichomonas vaginalis	adenylate cyclase, putative	0.018	0.0448	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.018	0.0448	0.5
Trichomonas vaginalis	adenylate cyclase, putative	0.018	0.0448	0.5
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.018	0.0448	0.5
Echinococcus multilocularis	p2X purinoceptor 4	0.3123	1	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0054	0.0039	0.0039
Trichomonas vaginalis	guanylate cyclase, putative	0.018	0.0448	0.5
Entamoeba histolytica	hypothetical protein	0.0042	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0051
Trichomonas vaginalis	adenylate cyclase type, putative	0.018	0.0448	0.5
Echinococcus multilocularis	neuropeptide s receptor	0.0054	0.0039	0.0039
Echinococcus granulosus	neuropeptide receptor A26	0.0054	0.0039	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0051
Schistosoma mansoni	amine GPCR	0.0054	0.0039	0.0038
Brugia malayi	neuropeptide F receptor	0.0054	0.0039	0.0856
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0054	0.0039	0.0039
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0054	0.0039	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0018	0.0016
Trichomonas vaginalis	adenylate cyclase, putative	0.018	0.0448	0.5
Brugia malayi	follicle stimulating hormone receptor	0.0054	0.0039	0.0856
Brugia malayi	hypothetical protein	0.0054	0.0039	0.0856
Schistosoma mansoni	hypothetical protein	0.0054	0.0039	0.0038
Echinococcus multilocularis	fmrfamide receptor	0.0054	0.0039	0.0039
Brugia malayi	hypothetical protein	0.0054	0.0039	0.0856
Trichomonas vaginalis	adenylate cyclase, putative	0.018	0.0448	0.5
Brugia malayi	Melatonin receptor type 1A	0.0054	0.0039	0.0856
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.018	0.0448	0.5
Echinococcus granulosus	dro:myosuppressin receptor	0.0054	0.0039	0.0039
Trichomonas vaginalis	adenylate cyclase, putative	0.018	0.0448	0.5
Trichomonas vaginalis	adenylate cyclase, putative	0.018	0.0448	0.5
Trichomonas vaginalis	guanylate cyclase, putative	0.018	0.0448	0.5
Schistosoma mansoni	biogenic amine receptor	0.0054	0.0039	0.0038
Brugia malayi	ORL1-like opioid receptor	0.0054	0.0039	0.0856
Schistosoma mansoni	neuropeptide receptor	0.0054	0.0039	0.0038
Schistosoma mansoni	hypothetical protein	0.018	0.0448	0.0448
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0054	0.0039	0.0039
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0054	0.0039	0.0038
Brugia malayi	TAR-binding protein	0.0068	0.0085	0.1898
Schistosoma mansoni	hypothetical protein	0.0054	0.0039	0.0038
Echinococcus multilocularis	neuropeptide Y receptor	0.0054	0.0039	0.0039
Trichomonas vaginalis	adenylate cyclase, putative	0.018	0.0448	0.5
Trichomonas vaginalis	adenylate cyclase type, putative	0.018	0.0448	0.5
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0051
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.0039	0.0038
Trichomonas vaginalis	guanylate cyclase beta 2 subunit, putative	0.018	0.0448	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.018	0.0448	0.5
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0051
Echinococcus granulosus	g-protein coupled receptor	0.0054	0.0039	0.0039
Echinococcus granulosus	rhodopsin orphan GPCR	0.0054	0.0039	0.0039
Schistosoma mansoni	biogenic amine receptor	0.0054	0.0039	0.0038
Trichomonas vaginalis	guanylate cyclase beta 1 subunit, putative	0.018	0.0448	0.5
Brugia malayi	G protein-coupled receptor	0.0054	0.0039	0.0856
Schistosoma mansoni	voltage-gated potassium channel	0.018	0.0448	0.0448
Trichomonas vaginalis	conserved hypothetical protein	0.018	0.0448	0.5
Schistosoma mansoni	neuropeptide receptor	0.0054	0.0039	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0051
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.018	0.0448	0.5
Echinococcus multilocularis	neuropeptide receptor	0.0054	0.0039	0.0039
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0054	0.0039	0.0039
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0054	0.0039	0.0039
Schistosoma mansoni	voltage-gated potassium channel	0.018	0.0448	0.0448
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.0039	0.0039
Trichomonas vaginalis	guanylate cyclase, putative	0.018	0.0448	0.5
Echinococcus granulosus	p2X purinoceptor 4	0.3123	1	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0051
Echinococcus multilocularis	voltage gated potassium channel	0.018	0.0448	0.0448
Trichomonas vaginalis	guanylate cyclase, putative	0.018	0.0448	0.5
Brugia malayi	G-protein coupled receptor	0.0054	0.0039	0.0856
Brugia malayi	Serotonin receptor	0.0054	0.0039	0.0856
Echinococcus granulosus	rhodopsin orphan GPCR	0.0054	0.0039	0.0039
Trichomonas vaginalis	adenylate cyclase, putative	0.018	0.0448	0.5
Brugia malayi	Bromodomain containing protein	0.0088	0.0149	0.3314
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0051
Echinococcus granulosus	g protein coupled receptor	0.0054	0.0039	0.0039
Brugia malayi	Dopamine receptor	0.0054	0.0039	0.0856
Brugia malayi	hypothetical protein	0.0054	0.0039	0.0856
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0054	0.0039	0.0038
Echinococcus multilocularis	neuropeptide receptor A26	0.0054	0.0039	0.0039
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.0039	0.0038
Schistosoma mansoni	hypothetical protein	0.0199	0.0508	0.0508
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0051
Brugia malayi	Bromodomain containing protein	0.0045	0.0009	0.0197
Brugia malayi	hypothetical protein	0.0054	0.0039	0.0856
Trichomonas vaginalis	hypothetical protein	0.018	0.0448	0.5
Trichomonas vaginalis	guanylate cyclase, putative	0.018	0.0448	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0054	0.0039	0.0039
Schistosoma mansoni	myosin xvIII	0.0054	0.0039	0.0038
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.0039	0.0039
Brugia malayi	putative neuropeptide receptor	0.0054	0.0039	0.0856
Trichomonas vaginalis	adenylate cyclase, putative	0.018	0.0448	0.5
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0051
Echinococcus granulosus	tar DNA binding protein	0.0068	0.0085	0.0085
Trichomonas vaginalis	conserved hypothetical protein	0.018	0.0448	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0085	0.0085
Echinococcus multilocularis	neuropeptide Y receptor	0.0054	0.0039	0.0039
Brugia malayi	hypothetical protein	0.0054	0.0039	0.0856
Trichomonas vaginalis	guanylate cyclase, putative	0.018	0.0448	0.5
Echinococcus granulosus	g protein coupled receptor	0.0054	0.0039	0.0039
Schistosoma mansoni	neuropeptide F-like receptor	0.0054	0.0039	0.0038
Trichomonas vaginalis	guanylate cyclase, putative	0.018	0.0448	0.5
Echinococcus granulosus	neuropeptide receptor	0.0054	0.0039	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0051
Loa Loa (eye worm)	hypothetical protein	0.005	0.0026	0.0029
Echinococcus multilocularis	sex peptide receptor	0.0054	0.0039	0.0039
Echinococcus multilocularis	dro:myosuppressin receptor	0.0054	0.0039	0.0039
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0054	0.0039	0.0039
Echinococcus multilocularis	fmrfamide receptor	0.0054	0.0039	0.0039
Trichomonas vaginalis	guanylate cyclase, putative	0.018	0.0448	0.5
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.018	0.0448	0.5
Loa Loa (eye worm)	melatonin receptor type 1A	0.0054	0.0039	0.0051
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0085	0.0085
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0054	0.0039	0.0038
Echinococcus multilocularis	tar DNA binding protein	0.0068	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0051
Brugia malayi	G-protein coupled receptor	0.0054	0.0039	0.0856
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0054	0.0039	0.0038
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0054	0.0039	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0051
Loa Loa (eye worm)	neuropeptide F receptor	0.0054	0.0039	0.0051
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0054	0.0039	0.0051
Brugia malayi	putative neuropeptide receptor NPR1	0.0054	0.0039	0.0856
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.018	0.0448	0.0448
Trichomonas vaginalis	conserved hypothetical protein	0.018	0.0448	0.5
Trichomonas vaginalis	guanylate cyclase, putative	0.018	0.0448	0.5
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0054	0.0039	0.0038
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.018	0.0448	0.5
Echinococcus multilocularis	somatostatin receptor	0.0054	0.0039	0.0039
Schistosoma mansoni	opsin-like receptor	0.0054	0.0039	0.0038
Echinococcus granulosus	neuropeptides capa receptor	0.0054	0.0039	0.0039
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.0039	0.0039
Brugia malayi	Serotonin receptor	0.0054	0.0039	0.0856
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.018	0.0448	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0054	0.0039	0.0039
Echinococcus granulosus	p2X purinoceptor 4	0.3123	1	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0051
Brugia malayi	Dopamine receptor protein 1	0.0054	0.0039	0.0856
Loa Loa (eye worm)	G-protein coupled receptor	0.0054	0.0039	0.0051
Trichomonas vaginalis	conserved hypothetical protein	0.018	0.0448	0.5
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.018	0.0448	0.5
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0054	0.0039	0.0039
Brugia malayi	Dopamine receptor protein 2	0.0054	0.0039	0.0856
Trichomonas vaginalis	guanylate cyclase, putative	0.018	0.0448	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.0039	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0051
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0054	0.0039	0.0039
Onchocerca volvulus		0.1803	0.5714	1
Trichomonas vaginalis	conserved hypothetical protein	0.018	0.0448	0.5
Schistosoma mansoni	hypothetical protein	0.0054	0.0039	0.0038
Schistosoma mansoni	neuropeptide F-like receptor	0.0054	0.0039	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0051
Brugia malayi	hypothetical protein	0.0054	0.0039	0.0856
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0054	0.0039	0.0051
Trichomonas vaginalis	adenylate cyclase, putative	0.018	0.0448	0.5
Trichomonas vaginalis	guanylate cyclase, putative	0.018	0.0448	0.5
Brugia malayi	larval opioid receptor	0.0054	0.0039	0.0856
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.0039	0.0039
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.0039	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0051
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0054	0.0039	0.0039
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0051
Schistosoma mansoni	neuropeptide f receptor 76f	0.0054	0.0039	0.0038
Brugia malayi	hypothetical protein	0.0054	0.0039	0.0856
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0051
Loa Loa (eye worm)	neuropeptide F receptor	0.0054	0.0039	0.0051
Echinococcus granulosus	g protein coupled receptor	0.0054	0.0039	0.0039
Schistosoma mansoni	biogenic amine receptor	0.0054	0.0039	0.0038
Schistosoma mansoni	neuropeptide receptor	0.0054	0.0039	0.0038
Schistosoma mansoni	histamine h1 receptor	0.0054	0.0039	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0051
Echinococcus granulosus	fmrfamide receptor	0.0054	0.0039	0.0039
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0085	0.0085
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.0039	0.0039
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.018	0.0448	0.5
Brugia malayi	aryl hydrocarbon receptor nuclear translocator protein, putative	0.018	0.0448	1
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0054	0.0039	0.0038
Entamoeba histolytica	hypothetical protein	0.0042	0	0.5
Trichomonas vaginalis	guanylate cyclase, putative	0.018	0.0448	0.5
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0054	0.0039	0.0039
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0054	0.0039	0.0038
Trichomonas vaginalis	adenylate cyclase type vIII, putative	0.018	0.0448	0.5
Trichomonas vaginalis	adenylate cyclase type IX, putative	0.018	0.0448	0.5
Entamoeba histolytica	hypothetical protein	0.0042	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0051
Schistosoma mansoni	neuropeptide receptor	0.0054	0.0039	0.0038
Echinococcus granulosus	7TM GPCR rhodopsin	0.0054	0.0039	0.0039
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.007	0.009	0.009
Echinococcus multilocularis	serotonin receptor	0.0054	0.0039	0.0039
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0054	0.0039	0.0856
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0054	0.0039	0.0039
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0054	0.0039	0.0039
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.0039	0.0038
Echinococcus granulosus	neuropeptides capa receptor	0.0054	0.0039	0.0039
Trichomonas vaginalis	adenylate cyclase type IX, putative	0.018	0.0448	0.5
Echinococcus granulosus	orexin receptor type 2	0.0054	0.0039	0.0039
Trichomonas vaginalis	conserved hypothetical protein	0.018	0.0448	0.5
Echinococcus multilocularis	geminin	0.0199	0.0508	0.0508
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.018	0.0448	0.5
Echinococcus granulosus	neuropeptide s receptor	0.0054	0.0039	0.0039
Brugia malayi	hypothetical protein	0.0054	0.0039	0.0856
Trichomonas vaginalis	guanylate cyclase, putative	0.018	0.0448	0.5
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.007	0.009	0.009
Trichomonas vaginalis	guanylate cyclase, putative	0.018	0.0448	0.5
Trichomonas vaginalis	adenylate cyclase type VI, putative	0.018	0.0448	0.5
Brugia malayi	G protein-coupled receptor F59B2.13	0.0054	0.0039	0.0856
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0054	0.0039	0.0038
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0054	0.0039	0.0856
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0054	0.0039	0.0039
Echinococcus multilocularis	g protein coupled receptor	0.0054	0.0039	0.0039
Echinococcus granulosus	geminin	0.0199	0.0508	0.0508
Echinococcus granulosus	rhodopsin orphan GPCR	0.0054	0.0039	0.0039
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0085	0.0085
Schistosoma mansoni	opsin-like receptor	0.0054	0.0039	0.0038
Brugia malayi	neuropeptide F receptor	0.0054	0.0039	0.0856
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0051
Echinococcus granulosus	voltage gated potassium channel	0.018	0.0448	0.0448
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0054	0.0039	0.0039
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0054	0.0039	0.0039
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0054	0.0039	0.0039
Schistosoma mansoni	hypothetical protein	0.0199	0.0508	0.0508
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0051
Echinococcus granulosus	hypothetical protein	0.0054	0.0039	0.0039
Loa Loa (eye worm)	CAMK/CAMKL/PASK protein kinase	0.1803	0.5714	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0054	0.0039	0.0856
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0051
Echinococcus granulosus	allatostatin A receptor	0.0054	0.0039	0.0039
Loa Loa (eye worm)	RNA binding protein	0.0068	0.0085	0.0133
Echinococcus multilocularis	G protein coupled receptor 139	0.0054	0.0039	0.0039
Echinococcus granulosus	rhodopsin orphan GPCR	0.0054	0.0039	0.0039
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0054	0.0039	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0051
Schistosoma mansoni	bromodomain containing protein	0.0074	0.0104	0.0104
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.018	0.0448	0.0448
Loa Loa (eye worm)	TAR-binding protein	0.0068	0.0085	0.0133
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0054	0.0039	0.0856
Entamoeba histolytica	hypothetical protein	0.0042	0	0.5
Echinococcus multilocularis	neuropeptides capa receptor	0.0054	0.0039	0.0039
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.018	0.0448	0.5
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0054	0.0039	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0051
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0054	0.0039	0.0856
Schistosoma mansoni	voltage-gated potassium channel	0.018	0.0448	0.0448
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0054	0.0039	0.0039
Echinococcus granulosus	neuropeptide receptor	0.0054	0.0039	0.0039
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.018	0.0448	1
Echinococcus granulosus	G protein coupled receptor 139	0.0054	0.0039	0.0039
Echinococcus multilocularis	orexin receptor type 2	0.0054	0.0039	0.0039
Trichomonas vaginalis	guanylate cyclase, putative	0.018	0.0448	0.5
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0051
Trichomonas vaginalis	adenylate cyclase, putative	0.018	0.0448	0.5
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0051
Echinococcus granulosus	rhodopsin orphan GPCR	0.0054	0.0039	0.0039
Loa Loa (eye worm)	TYRA-2 protein	0.0054	0.0039	0.0051
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.0039	0.0038
Trichomonas vaginalis	conserved hypothetical protein	0.018	0.0448	0.5
Trichomonas vaginalis	guanylate cyclase, putative	0.018	0.0448	0.5
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0132	0.0216
Brugia malayi	AKH receptor	0.0054	0.0039	0.0856
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0054	0.0039	0.0051
Echinococcus multilocularis	g-protein coupled receptor	0.0054	0.0039	0.0039
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.018	0.0448	0.5
Brugia malayi	RNA recognition motif domain containing protein	0.0068	0.0085	0.1898
Trichomonas vaginalis	adenylate cyclase type III, putative	0.018	0.0448	0.5
Echinococcus multilocularis	neuropeptide receptor	0.0054	0.0039	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0039	0.0051
Echinococcus granulosus	tm gpcr rhodopsin	0.0054	0.0039	0.0039
Brugia malayi	sulfakinin receptor protein	0.0054	0.0039	0.0856
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0054	0.0039	0.0038
Loa Loa (eye worm)	G-protein coupled receptor	0.0054	0.0039	0.0051
Schistosoma mansoni	voltage-gated potassium channel	0.018	0.0448	0.0448
Trichomonas vaginalis	adenylate cyclase type III, putative	0.018	0.0448	0.5
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0054	0.0039	0.0039
Brugia malayi	RE15519p	0.0054	0.0039	0.0856

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)		Antibacterial activity against Escherichia coli MTCC 739 at 1.4 to 300 ug/ml after 24 hr by microtiter broth dilution method	ChEMBL.	No reference
IC50 (functional)	= 14.96 uM	Cytotoxicity against Homo sapiens (human) MDA-MB-231 cells by tetrazolium-reduction assay	ChEMBL.	No reference
MIC (functional)		Antifungal activity against Candida albicans MTCC 3017 after 24 hr by microtiter broth dilution method	ChEMBL.	No reference
MIC (functional)	= 75 ug ml-1	Antifungal activity against Candida albicans MTCC 3018 after 24 hr by microtiter broth dilution method	ChEMBL.	No reference
MIC (functional)	= 75 ug ml-1	Antifungal activity against Candida albicans MTCC 227 after 24 hr by microtiter broth dilution method	ChEMBL.	No reference
MIC (functional)	= 150 ug ml-1	Antifungal activity against Candida albicans MTCC 3958 after 24 hr by microtiter broth dilution method	ChEMBL.	No reference
MIC (functional)	= 150 ug ml-1	Antifungal activity against Candida albicans MTCC 7315 after 24 hr by microtiter broth dilution method	ChEMBL.	No reference
MIC (functional)	= 150 ug ml-1	Antifungal activity against Candida albicans MTCC 1637 after 24 hr by microtiter broth dilution method	ChEMBL.	No reference
MIC (functional)	= 300 ug ml-1	Antifungal activity against Candida albicans MTCC 854 after 24 hr by microtiter broth dilution method	ChEMBL.	No reference
MIC (functional)	= 300 ug ml-1	Antifungal activity against Candida albicans MTCC 183 after 24 hr by microtiter broth dilution method	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2298076

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1794082