Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0769 | 1 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0754 | 0.9777 | 0.9777 |
Brugia malayi | amidase | 0.0754 | 0.9777 | 0.9777 |
Trypanosoma brucei | lipase domain protein, putative | 0.0769 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0769 | 1 | 1 |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0091 | 0 | 0.5 |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0091 | 0 | 0.5 |
Plasmodium falciparum | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0091 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0769 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0754 | 0.9777 | 0.9777 |
Leishmania major | hypothetical protein, conserved | 0.0769 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0091 | 0 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.0769 | 1 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0754 | 0.9777 | 0.9777 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0754 | 0.9777 | 1 |
Loa Loa (eye worm) | lipase | 0.0769 | 1 | 1 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0769 | 1 | 1 |
Plasmodium vivax | glutamyl-tRNA(Gln) amidotransferase subunit A, putative | 0.0091 | 0 | 0.5 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0754 | 0.9777 | 0.9777 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0769 | 1 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0769 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) | 0.0091 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE AMIDASE AMIC (AMINOHYDROLASE) | 0.0091 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0155 | 0.0941 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0754 | 0.9777 | 0.9777 |
Schistosoma mansoni | amidase | 0.0754 | 0.9777 | 1 |
Onchocerca volvulus | 0.0769 | 1 | 0.5 | |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0155 | 0.0941 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 2.541 mmol/L | Hypoglycemic activity in Homo sapiens (human) HepG2 cells assessed as glucose consumption at 100 mg/l after 24 hr by glucose enzymatic assay (Rvb = 1.972 +/-0.071 mmol/l) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.