Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | transient receptor potential cation channel, subfamily M, member 8 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | transient receptor potential cation channel | transient receptor potential cation channel, subfamily M, member 8 | 1104 aa | 1115 aa | 24.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | C-8 sterol isomerase-like protein | 0.0368 | 0.1037 | 0.3091 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0125 | 0 | 0.5 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.091 | 0.3354 | 1 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.091 | 0.3354 | 1 |
Leishmania major | fk506-binding protein 1-like protein | 0.091 | 0.3354 | 1 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.091 | 0.3354 | 0.3354 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0368 | 0.1037 | 0.3091 |
Toxoplasma gondii | peptidyl-prolyl isomerase FKBP12, putative | 0.0125 | 0 | 0.5 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.049 | 0.156 | 0.4545 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0803 | 0.2897 | 0.8441 |
Onchocerca volvulus | 0.0125 | 0 | 0.5 | |
Mycobacterium tuberculosis | Probable trigger factor (TF) protein Tig | 0.0125 | 0 | 0.5 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0928 | 0.3432 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.0928 | 0.3432 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.091 | 0.3354 | 1 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.091 | 0.3354 | 1 |
Onchocerca volvulus | 0.0125 | 0 | 0.5 | |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.049 | 0.156 | 0.4652 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.091 | 0.3354 | 1 |
Trichomonas vaginalis | immunophilin, putative | 0.091 | 0.3354 | 1 |
Echinococcus multilocularis | FK506 binding protein 8, 38 kDa | 0.0144 | 0.0079 | 0.023 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.091 | 0.3354 | 1 |
Chlamydia trachomatis | peptidyl-prolyl cis-trans isomerase | 0.0125 | 0 | 0.5 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0125 | 0 | 0.5 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.091 | 0.3354 | 1 |
Echinococcus multilocularis | fk506 binding protein | 0.091 | 0.3354 | 0.977 |
Loa Loa (eye worm) | hypothetical protein | 0.0368 | 0.1037 | 0.3091 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.091 | 0.3354 | 1 |
Loa Loa (eye worm) | FKBP5 protein | 0.091 | 0.3354 | 1 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0125 | 0 | 0.5 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0803 | 0.2897 | 0.8441 |
Mycobacterium leprae | PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG | 0.0125 | 0 | 0.5 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0191 | 0.0281 | 0.0839 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.091 | 0.3354 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.091 | 0.3354 | 0.977 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.049 | 0.156 | 0.4545 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.091 | 0.3354 | 1 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.091 | 0.3354 | 1 |
Schistosoma mansoni | immunophilin | 0.0928 | 0.3432 | 0.3432 |
Brugia malayi | gamma-secretase subunit aph-1 | 0.049 | 0.156 | 0.4652 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0125 | 0 | 0.5 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.091 | 0.3354 | 1 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.091 | 0.3354 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0928 | 0.3432 | 1 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.091 | 0.3354 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.0928 | 0.3432 | 1 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.091 | 0.3354 | 1 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.091 | 0.3354 | 1 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.091 | 0.3354 | 1 |
Schistosoma mansoni | immunophilin | 0.0803 | 0.2897 | 0.2897 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0191 | 0.0281 | 0.0839 |
Schistosoma mansoni | immunophilin | 0.0928 | 0.3432 | 0.3432 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.049 | 0.156 | 0.156 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0125 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.0268 | 0.08 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.091 | 0.3354 | 1 |
Schistosoma mansoni | family A2 unassigned peptidase (A02 family) | 0.0448 | 0.138 | 0.138 |
Trypanosoma brucei | Aph-1 protein, putative | 0.0191 | 0.0281 | 0.0839 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.091 | 0.3354 | 1 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0368 | 0.1037 | 0.3091 |
Loa Loa (eye worm) | hypothetical protein | 0.0785 | 0.2819 | 0.8405 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0368 | 0.1037 | 0.3091 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1230 nM | Inhibition of human TRPM8 (unknown origin) expressed in HEK293 cells assessed as inhibition of WS12-induced Ca2+ elevation by FLIPR assay | ChEMBL. | 24080460 |
Kb (binding) | = 1430 nM | Inhibition of human TRPM8 (unknown origin) expressed in HEK293 cells assessed as inhibition of WS12-induced Ca2+ elevation by FLIPR assay | ChEMBL. | 24080460 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.