Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0046 | 0.0266 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0046 | 0.0266 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0022 | 0 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0 | 0.5 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0046 | 0.0266 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0022 | 0 | 0.5 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.018 | 0.1725 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0046 | 0.0266 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0022 | 0 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0046 | 0.0266 | 0.1545 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | survival motor neuron protein | 0.0037 | 0.0163 | 0.6111 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0401 | 0.4141 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0022 | 0 | 0.5 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0163 | 0.6111 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0022 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0022 | 0 | 0.5 |
Onchocerca volvulus | 0.0401 | 0.4141 | 1 | |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0046 | 0.0266 | 0.0266 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0037 | 0.0163 | 0.0393 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.018 | 0.1725 | 0.1725 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0046 | 0.0266 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0022 | 0 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0046 | 0.0266 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0046 | 0.0266 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0046 | 0.0266 | 1 |
Brugia malayi | hypothetical protein | 0.018 | 0.1725 | 0.4165 |
Onchocerca volvulus | 0.0401 | 0.4141 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.1725 | 0.4165 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0401 | 0.4141 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.