Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0067 | 0.083 | 0.4775 |
Schistosoma mansoni | amine oxidase | 0.0067 | 0.083 | 0.4775 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0067 | 0.083 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.1738 | 0.6346 |
Schistosoma mansoni | amine oxidase | 0.0067 | 0.083 | 0.4775 |
Brugia malayi | Myb-like DNA-binding domain containing protein | 0.0198 | 0.2658 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.083 | 0.303 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0067 | 0.083 | 0.4775 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0067 | 0.083 | 0.5 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0067 | 0.083 | 0.5 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0067 | 0.083 | 0.4775 |
Loa Loa (eye worm) | hypothetical protein | 0.0204 | 0.2738 | 1 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0067 | 0.083 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0727 | 1 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0067 | 0.083 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 0.2658 | 0.9706 |
Onchocerca volvulus | CoRest homolog | 0.0204 | 0.2738 | 1 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.066 | 0.9074 | 1 |
Brugia malayi | SWIRM domain containing protein | 0.0139 | 0.1834 | 0.6901 |
Brugia malayi | hypothetical protein | 0.0067 | 0.083 | 0.3122 |
Echinococcus multilocularis | 0.0067 | 0.083 | 0.4775 | |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.1738 | 0.6346 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0074 | 0.0926 | 0.3485 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0132 | 0.1738 | 1 |
Leishmania major | UDP-galactopyranose mutase | 0.0067 | 0.083 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0926 | 0.3382 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.1834 | 0.6698 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0067 | 0.083 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.083 | 0.303 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0067 | 0.083 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0067 | 0.083 | 0.5 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0132 | 0.1738 | 1 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0067 | 0.083 | 0.5 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0067 | 0.083 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0067 | 0.083 | 0.5 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0067 | 0.083 | 0.5 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0132 | 0.1738 | 1 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0067 | 0.083 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | = 68.16 uM | Cytotoxicity against Homo sapiens (human) HEK293 cells assessed as inhibition of cell viability after 72 hr by MTT assay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.