Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0446 | 0.2583 | 0.3344 |
Leishmania major | UDP-galactopyranose mutase | 0.0232 | 0.1258 | 1 |
Onchocerca volvulus | CoRest homolog | 0.0871 | 0.5221 | 1 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0232 | 0.1258 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0582 | 0.3431 | 0.5484 |
Brugia malayi | SWIRM domain containing protein | 0.0469 | 0.2724 | 0.3848 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0232 | 0.1258 | 1 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0232 | 0.1258 | 1 |
Brugia malayi | Myb-like DNA-binding domain containing protein | 0.0846 | 0.5068 | 1 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0446 | 0.2583 | 1 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0232 | 0.1258 | 0.4869 |
Schistosoma mansoni | amine oxidase | 0.0232 | 0.1258 | 0.4869 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0446 | 0.2583 | 1 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0232 | 0.1258 | 1 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0232 | 0.1258 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0232 | 0.1258 | 1 |
Trypanosoma brucei | CW-type Zinc Finger, putative | 0.003 | 0 | 0.5 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0232 | 0.1258 | 0.5 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0232 | 0.1258 | 0.4869 |
Echinococcus multilocularis | 0.0232 | 0.1258 | 0.4869 | |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0605 | 0.3572 | 0.6074 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0446 | 0.2583 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0232 | 0.1258 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0446 | 0.2583 | 0.3344 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.1408 | 0.8558 | 1 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0232 | 0.1258 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0635 | 0.3756 | 0.6303 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0232 | 0.1258 | 0.4869 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.1641 | 1 | 1 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0232 | 0.1258 | 1 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0232 | 0.1258 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0469 | 0.2724 | 0.3699 |
Schistosoma mansoni | amine oxidase | 0.0232 | 0.1258 | 0.4869 |
Loa Loa (eye worm) | hypothetical protein | 0.0871 | 0.5221 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0846 | 0.5068 | 0.9613 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0232 | 0.1258 | 1 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0232 | 0.1258 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | > 100 uM | Cytotoxicity against Homo sapiens (human) HEK293 cells assessed as inhibition of cell viability after 72 hr by MTT assay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.