Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | amine oxidase | 0.0104 | 0.0726 | 0.6379 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0157 | 0.1139 | 1 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0104 | 0.0726 | 0.6379 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0104 | 0.0726 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.077 | 0.2764 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.1182 | 0.4244 |
Leishmania major | UDP-galactopyranose mutase | 0.0104 | 0.0726 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.0726 | 0.2607 |
Plasmodium vivax | hypothetical protein, conserved | 0.0104 | 0.0726 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.0726 | 0.2607 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0157 | 0.1139 | 1 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0104 | 0.0726 | 0.5 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0104 | 0.0726 | 0.5 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0104 | 0.0726 | 0.6379 |
Plasmodium vivax | hypothetical protein, conserved | 0.0104 | 0.0726 | 0.5 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0104 | 0.0726 | 0.6379 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0104 | 0.0726 | 0.5 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0104 | 0.0726 | 0.5 |
Schistosoma mansoni | amine oxidase | 0.0104 | 0.0726 | 0.6379 |
Onchocerca volvulus | CoRest homolog | 0.037 | 0.2786 | 1 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.1299 | 1 | 1 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0104 | 0.0726 | 0.5 |
Echinococcus multilocularis | 0.0104 | 0.0726 | 0.6379 | |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0104 | 0.0726 | 0.5 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0104 | 0.0726 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.1139 | 0.4087 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0104 | 0.0726 | 0.5 |
Brugia malayi | Myb-like DNA-binding domain containing protein | 0.0359 | 0.2704 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0104 | 0.0726 | 0.5 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0104 | 0.0726 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.1139 | 0.4087 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.011 | 0.077 | 0.0221 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0157 | 0.1139 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.037 | 0.2786 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0359 | 0.2704 | 0.9708 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.1195 | 0.9192 | 1 |
Brugia malayi | SWIRM domain containing protein | 0.0163 | 0.1182 | 0.2306 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 13 mm | Antibacterial activity against Escherichia coli at 300 ug/ml | ChEMBL. | No reference |
IZ (functional) | = 16 mm | Antifungal activity against Candida albicans at 300 ug/ml | ChEMBL. | No reference |
MIC (functional) | = 100 ug ml-1 | Antifungal activity against Candida albicans | ChEMBL. | No reference |
MIC (functional) | = 200 ug ml-1 | Antibacterial activity against Escherichia coli | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.