Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0886 | 0.5056 | 0.961 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.1723 | 1 | 1 |
Echinococcus multilocularis | 0.0247 | 0.1278 | 0.4749 | |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0247 | 0.1278 | 1 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0247 | 0.1278 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0486 | 0.2692 | 0.3595 |
Brugia malayi | SWIRM domain containing protein | 0.0512 | 0.2842 | 0.4138 |
Plasmodium vivax | hypothetical protein, conserved | 0.0247 | 0.1278 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0486 | 0.2692 | 0.3595 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0247 | 0.1278 | 0.4749 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0247 | 0.1278 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0671 | 0.378 | 0.6364 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0247 | 0.1278 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0247 | 0.1278 | 1 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.1476 | 0.8538 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0486 | 0.2692 | 1 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0247 | 0.1278 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0512 | 0.2842 | 0.3977 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0247 | 0.1278 | 1 |
Schistosoma mansoni | amine oxidase | 0.0247 | 0.1278 | 0.4749 |
Onchocerca volvulus | CoRest homolog | 0.0912 | 0.5209 | 1 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0247 | 0.1278 | 1 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0247 | 0.1278 | 1 |
Brugia malayi | Myb-like DNA-binding domain containing protein | 0.0886 | 0.5056 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0614 | 0.3447 | 0.5516 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0486 | 0.2692 | 1 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0247 | 0.1278 | 0.5 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0247 | 0.1278 | 1 |
Schistosoma mansoni | amine oxidase | 0.0247 | 0.1278 | 0.4749 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0247 | 0.1278 | 0.4749 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0247 | 0.1278 | 0.4749 |
Leishmania major | UDP-galactopyranose mutase | 0.0247 | 0.1278 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0247 | 0.1278 | 1 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.064 | 0.3597 | 0.6137 |
Trypanosoma brucei | CW-type Zinc Finger, putative | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0912 | 0.5209 | 1 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0486 | 0.2692 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CL (ADMET) | = 20 ml/min.kg | Intrinsic clearance in human hepatocytes | ChEMBL. | 24080461 |
INH (ADMET) | = 4.6 uM | Inhibition of CYP3A4 (unknown origin) | ChEMBL. | 24080461 |
INH (ADMET) | = 7.2 uM | Inhibition of CYP2C9 (unknown origin) | ChEMBL. | 24080461 |
INH (ADMET) | = 7.7 uM | Inhibition of CYP1A2 (unknown origin) | ChEMBL. | 24080461 |
INH (ADMET) | = 8.4 uM | Inhibition of CYP2D6 (unknown origin) | ChEMBL. | 24080461 |
Inhibition (binding) | = 75 % | Inhibition of melatonin MT1 receptor (unknown origin) at 10 uM by radioligand binding assay | ChEMBL. | 24080461 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.