Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.00455749 | 0.189945 | 0.0482895 |
Echinococcus multilocularis | roundabout 2 | 0.00455749 | 0.189945 | 0.0482895 |
Trypanosoma brucei | CMGC/DYRK protein kinase, putative | 0.0193229 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0191803 | 0.992176 | 0.990807 |
Schistosoma mansoni | serine/threonine protein kinase | 0.00633052 | 0.287216 | 0.287216 |
Loa Loa (eye worm) | hypothetical protein | 0.00455749 | 0.189945 | 0.0482895 |
Trichomonas vaginalis | CMGC family protein kinase | 0.00633052 | 0.287216 | 0.5 |
Toxoplasma gondii | cell-cycle-associated protein kinase CLK, putative | 0.00633052 | 0.287216 | 0.5 |
Echinococcus granulosus | dual specificity | 0.0193229 | 1 | 1 |
Loa Loa (eye worm) | CMGC/CLK protein kinase | 0.00633052 | 0.287216 | 0.162571 |
Echinococcus granulosus | hypothetical protein | 0.0061879 | 0.279392 | 0.153378 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0193229 | 1 | 1 |
Schistosoma mansoni | nephrin | 0.0038083 | 0.148843 | 0.148843 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.00490352 | 0.208929 | 0.0705931 |
Plasmodium falciparum | protein serine/threonine kinase-1 | 0.00633052 | 0.287216 | 0.5 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0038083 | 0.148843 | 0.148843 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0193229 | 1 | 0.5 |
Echinococcus granulosus | twitchin | 0.00395092 | 0.156668 | 0.00919278 |
Schistosoma mansoni | cell adhesion molecule | 0.00455749 | 0.189945 | 0.189945 |
Brugia malayi | Protein kinase domain containing protein | 0.00633052 | 0.287216 | 0.162571 |
Schistosoma mansoni | serine/threonine protein kinase | 0.00633052 | 0.287216 | 0.287216 |
Loa Loa (eye worm) | hypothetical protein | 0.0061879 | 0.279392 | 0.153378 |
Schistosoma mansoni | vesicular amine transporter | 0.0038083 | 0.148843 | 0.148843 |
Plasmodium vivax | serine/threonine kinase-1, putative | 0.00633052 | 0.287216 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.00490352 | 0.208929 | 0.0705931 |
Brugia malayi | Protein kinase domain containing protein | 0.0193229 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00455749 | 0.189945 | 0.0482895 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.0193229 | 1 | 1 |
Echinococcus granulosus | dual specificity protein kinase clk2 | 0.00633052 | 0.287216 | 0.162571 |
Echinococcus multilocularis | dual specificity protein kinase clk2 | 0.00633052 | 0.287216 | 0.162571 |
Loa Loa (eye worm) | hypothetical protein | 0.00455749 | 0.189945 | 0.0482895 |
Echinococcus granulosus | roundabout 2 | 0.00455749 | 0.189945 | 0.0482895 |
Entamoeba histolytica | protein kinase, putative | 0.0193229 | 1 | 0.5 |
Giardia lamblia | Kinase, CMGC CLK | 0.00633052 | 0.287216 | 0.5 |
Echinococcus multilocularis | 0.0061879 | 0.279392 | 0.153378 | |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0038083 | 0.148843 | 0.148843 |
Entamoeba histolytica | hypothetical protein | 0.0193229 | 1 | 0.5 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0193229 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0191803 | 0.992176 | 0.990807 |
Entamoeba histolytica | protein kinase, putative | 0.0193229 | 1 | 0.5 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.0193229 | 1 | 1 |
Echinococcus multilocularis | dual specificity | 0.0193229 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0193229 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 11.7 nM | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen infected in 3T3 cells after 7 days by beta-galactosidase assay | ChEMBL. | 24120539 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma cruzi | ChEMBL23 | 24120539 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.