Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Putative fad oxidoreductase | 0.0104 | 0.0678 | 0.5 |
Trypanosoma brucei | glycerol-3-phosphate dehydrogenase (FAD-dependent), putative | 0.0104 | 0.0678 | 0.5 |
Mycobacterium tuberculosis | Probable D-amino acid oxidase Aao | 0.1146 | 0.9152 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.0678 | 0.0678 |
Mycobacterium ulcerans | D-amino acid oxidase Aao | 0.125 | 1 | 1 |
Trypanosoma cruzi | L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative | 0.0104 | 0.0678 | 0.5 |
Schistosoma mansoni | ATP:guanidino kinase (Smc74) | 0.0104 | 0.0678 | 0.0678 |
Leishmania major | glycerol-3-phosphate dehydrogenase-like protein | 0.0104 | 0.0678 | 0.5 |
Trypanosoma cruzi | glycerol-3-phosphate dehydrogenase, putative | 0.0104 | 0.0678 | 0.5 |
Trypanosoma brucei | FAD dependent oxidoreductase, putative | 0.0104 | 0.0678 | 0.5 |
Schistosoma mansoni | d-amino acid oxidase | 0.125 | 1 | 1 |
Brugia malayi | dimethylglycine dehydrogenase, mitochondrial precursor, putative | 0.0104 | 0.0678 | 1 |
Trypanosoma cruzi | glycerol-3-phosphate dehydrogenase (FAD-dependent), putative | 0.0104 | 0.0678 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0411 | 0.0411 |
Schistosoma mansoni | glycerol-3-phosphate dehydrogenase | 0.0104 | 0.0678 | 0.0678 |
Schistosoma mansoni | fad oxidoreductase | 0.0104 | 0.0678 | 0.0678 |
Echinococcus granulosus | glycerol 3 phosphate dehydrogenase | 0.0104 | 0.0678 | 1 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0023 | 0.0016 | 0.0016 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.006 | 0.032 | 0.4599 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0036 | 0.0125 | 0.1657 |
Schistosoma mansoni | bromodomain containing protein | 0.0064 | 0.035 | 0.035 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.006 | 0.032 | 0.4599 |
Brugia malayi | RE18450p | 0.0104 | 0.0678 | 1 |
Trypanosoma cruzi | L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative | 0.0104 | 0.0678 | 0.5 |
Trypanosoma brucei | L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative | 0.0104 | 0.0678 | 0.5 |
Entamoeba histolytica | anaerobic glycerol-3-phosphate dehydrogenase subunit A, putative | 0.0104 | 0.0678 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0104 | 0.0678 | 0.5 |
Brugia malayi | cDNA sequence BC016226 | 0.0104 | 0.0678 | 1 |
Onchocerca volvulus | Dimethylglycine dehydrogenase, mitochondrial homolog | 0.0104 | 0.0678 | 0.5 |
Trypanosoma cruzi | FAD dependent oxidoreductase, putative | 0.0104 | 0.0678 | 0.5 |
Giardia lamblia | Glycerol-3-phosphate dehydrogenase | 0.0104 | 0.0678 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0165 | 0.0165 |
Trypanosoma brucei | glycerol-3-phosphate dehydrogenase (FAD-dependent), mitochondrial | 0.0104 | 0.0678 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.0678 | 0.0678 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0145 | 0.0145 |
Brugia malayi | Bromodomain containing protein | 0.0039 | 0.0145 | 0.1707 |
Trypanosoma cruzi | glycerol-3-phosphate dehydrogenase (FAD-dependent), putative | 0.0104 | 0.0678 | 0.5 |
Brugia malayi | pyruvate dehydrogenase phosphatase regulatory subunit precursor | 0.0104 | 0.0678 | 1 |
Plasmodium vivax | FAD-dependent glycerol-3-phosphate dehydrogenase, putative | 0.0104 | 0.0678 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0076 | 0.0446 | 0.6386 |
Schistosoma mansoni | fad oxidoreductase | 0.0104 | 0.0678 | 0.0678 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0036 | 0.0125 | 0.1657 |
Loa Loa (eye worm) | glycerol-3-phosphate dehydrogenase | 0.0104 | 0.0678 | 0.0678 |
Onchocerca volvulus | Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial homolog | 0.0104 | 0.0678 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0104 | 0.0678 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0181 | 0.0181 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 20 | 0.0104 | 0.0678 | 0.5 |
Plasmodium falciparum | FAD-dependent glycerol-3-phosphate dehydrogenase, putative | 0.0104 | 0.0678 | 0.5 |
Entamoeba histolytica | NAD(FAD)-dependent dehydrogenase, putative | 0.0104 | 0.0678 | 0.5 |
Toxoplasma gondii | FAD-dependent glycerol-3-phosphate dehydrogenase | 0.0104 | 0.0678 | 0.5 |
Echinococcus multilocularis | glycerol 3 phosphate dehydrogenase | 0.0104 | 0.0678 | 1 |
Echinococcus multilocularis | FAD dependent oxidoreductase domain containing protein | 0.0104 | 0.0678 | 1 |
Chlamydia trachomatis | D-amino acid dehydrogenase | 0.0104 | 0.0678 | 0.5 |
Mycobacterium leprae | PROBABLE D-AMINO ACID OXIDASE AAO | 0.125 | 1 | 1 |
Echinococcus granulosus | FAD dependent oxidoreductase domain containing protein | 0.0104 | 0.0678 | 1 |
Trypanosoma brucei | electron transfer flavoprotein-ubiquinone oxidoreductase, putative | 0.0104 | 0.0678 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0104 | 0.0678 | 0.5 |
Schistosoma mansoni | NAD dehydrogenase | 0.0104 | 0.0678 | 0.0678 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.0678 | 0.0678 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | Toxicity in albino CF-1 Mus musculus (mouse) assessed as motor impairment at 300 mg/kg measured after 0.5 hr by rotarod test | ChEMBL. | No reference | |
Activity (ADMET) | Toxicity in albino CF-1 Mus musculus (mouse) assessed as motor impairment at 300 mg/kg measured after 4 hr by rotarod test | ChEMBL. | No reference | |
Activity (ADMET) | = 110.81 % | Induction of CNS depressant activity in albino CF-1 Mus musculus (mouse) assessed as increase in immobility at 100 mg/kg, ip measured after 30 min by Porsolt's force swim pool method | ChEMBL. | No reference |
MED (functional) | = 100 mg kg-1 | Anticonvulsant activity in albino CF-1 Mus musculus (mouse) assessed as minimum dose required to protect half or more animals against maximal electroshock-induced seizures measured after 4 hr by electroshock seizure method | ChEMBL. | No reference |
MED (functional) | = 300 mg kg-1 | Anticonvulsant activity in albino CF-1 Mus musculus (mouse) assessed as minimum dose required to protect half or more animals against maximal electroshock-induced seizures measured after 0.5 hr by electroshock seizure method | ChEMBL. | No reference |
TIME (ADMET) | = 111.1 s | Induction of CNS depressant activity in albino CF-1 Mus musculus (mouse) assessed as duration of immobility at 100 mg/kg, ip measured after 30 min by Porsolt's force swim pool method (Rvb = 52.7 +/-0.70 secs) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.