Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | 0.0353 | 1 | 1 |
Echinococcus granulosus | proto oncogene serine:threonine protein kinase | 0.0353 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.006 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0063 | 0.0086 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.006 | 0 | 0.5 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0063 | 0.0086 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0086 | 0.0086 |
Entamoeba histolytica | protein kinase domain containing protein | 0.006 | 0 | 0.5 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0308 | 0.8467 | 0.8467 |
Mycobacterium ulcerans | oxidoreductase | 0.0063 | 0.0086 | 0.5 |
Echinococcus multilocularis | 0.0063 | 0.0086 | 0.0086 | |
Entamoeba histolytica | protein kinase, putative | 0.006 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0334 | 0.9357 | 0.9357 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0308 | 0.8467 | 0.8467 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0063 | 0.0086 | 0.0086 |
Plasmodium vivax | hypothetical protein, conserved | 0.0063 | 0.0086 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0063 | 0.0086 | 1 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0063 | 0.0086 | 1 |
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.0353 | 1 | 1 |
Giardia lamblia | Kinase, CMGC GSK | 0.006 | 0 | 0.5 |
Mycobacterium ulcerans | dehydrogenase | 0.0063 | 0.0086 | 0.5 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0063 | 0.0086 | 0.5 |
Mycobacterium ulcerans | monoamine oxidase | 0.0063 | 0.0086 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0063 | 0.0086 | 0.5 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0353 | 1 | 1 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0063 | 0.0086 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0308 | 0.8467 | 0.8467 |
Echinococcus multilocularis | proto oncogene serine:threonine protein kinase | 0.0353 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0308 | 0.8467 | 0.8467 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0086 | 0.0086 |
Schistosoma mansoni | amine oxidase | 0.0063 | 0.0086 | 0.0086 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0353 | 1 | 1 |
Giardia lamblia | Kinase, CMGC GSK | 0.006 | 0 | 0.5 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0063 | 0.0086 | 1 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0089 | 0.0976 | 0.0976 |
Plasmodium vivax | hypothetical protein, conserved | 0.0063 | 0.0086 | 1 |
Onchocerca volvulus | 0.0334 | 0.9357 | 0.9357 | |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0063 | 0.0086 | 0.0086 |
Trypanosoma brucei | protein kinase, putative | 0.006 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0063 | 0.0086 | 0.0086 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0063 | 0.0086 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0063 | 0.0086 | 0.0086 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0976 | 0.0976 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0063 | 0.0086 | 1 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0063 | 0.0086 | 0.5 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0063 | 0.0086 | 0.5 |
Leishmania major | UDP-galactopyranose mutase | 0.0063 | 0.0086 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.006 | 0 | 0.5 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0063 | 0.0086 | 1 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0063 | 0.0086 | 0.5 |
Schistosoma mansoni | amine oxidase | 0.0063 | 0.0086 | 0.0086 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0063 | 0.0086 | 0.5 |
Brugia malayi | SWIRM domain containing protein | 0.0334 | 0.9357 | 0.9357 |
Onchocerca volvulus | Serine\/threonine protein kinase homolog | 0.0353 | 1 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0063 | 0.0086 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0308 | 0.8467 | 0.8467 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.