Detailed information for compound 1797148

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 405.917 | Formula: C25H24ClNO2
  • H donors: 1 H acceptors: 0 LogP: 7.31 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCOc1ccccc1C(Nc1ccc(cc1)Oc1ccc(cc1)Cl)CC=C
  • InChi: 1S/C25H24ClNO2/c1-3-7-24(23-8-5-6-9-25(23)28-18-4-2)27-20-12-16-22(17-13-20)29-21-14-10-19(26)11-15-21/h3-6,8-17,24,27H,1-2,7,18H2
  • InChiKey: QMIDCUROTQRKBR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis lysine specific demethylase 5A 0.006 0.0297 0.0297
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0248 0.061
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0161 0.0396
Loa Loa (eye worm) hypothetical protein 0.0056 0.0274 0.0943
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0005 0.0005
Schistosoma mansoni lamin 0.0056 0.0274 0.0661
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0072 0.0165
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0072 0.0201
Loa Loa (eye worm) hypothetical protein 0.0022 0.0072 0.0249
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0072 0.0165
Echinococcus granulosus Transglutaminase 0.0578 0.3346 0.8221
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.0261 0.0631
Loa Loa (eye worm) hypothetical protein 0.0022 0.0072 0.0249
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0017
Brugia malayi steroid hormone receptor 0.0022 0.0072 0.0201
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0281 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0072 0.0249
Loa Loa (eye worm) hypothetical protein 0.0055 0.0268 0.0922
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0078 0.0404 0.6954
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0072 0.0165
Plasmodium vivax JmjC domain containing protein 0.0016 0.0039 0.5
Mycobacterium leprae Conserved hypothetical protein 0.0578 0.3346 1
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0167 0.0167
Brugia malayi jmjC domain containing protein 0.0016 0.0039 0.0101
Schistosoma mansoni hypothetical protein 0.0037 0.0161 0.0384
Brugia malayi nuclear hormone receptor 0.0022 0.0072 0.0201
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0503 0.2902 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0066 0.0336 0.0825
Echinococcus granulosus lamin dm0 0.0056 0.0274 0.0672
Echinococcus multilocularis geminin 0.0345 0.1976 0.1976
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0017
Loa Loa (eye worm) hypothetical protein 0.0011 0.0012 0.0042
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0072 0.0165
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0017
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0072 0.0177
Mycobacterium tuberculosis Hypothetical protein 0.0578 0.3346 1
Echinococcus multilocularis musashi 0.0056 0.0274 0.0274
Loa Loa (eye worm) hypothetical protein 0.0143 0.0789 0.272
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0072 0.0201
Loa Loa (eye worm) hypothetical protein 0.0026 0.0098 0.0336
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0072 0.0249
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0072 0.0201
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0078 0.0404 0.0404
Loa Loa (eye worm) hypothetical protein 0.0022 0.0072 0.0249
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0078 0.0404 0.6954
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0072 0.0177
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0072 0.0249
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0072 0.0201
Loa Loa (eye worm) latrophilin receptor protein 2 0.0066 0.0336 0.1157
Brugia malayi follicle stimulating hormone receptor 0.0503 0.2902 0.8671
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0017
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0072 0.0165
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0039 0.0083
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0072 0.0201
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0072 0.0072
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0248 0.0598
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0248 0.0855
Echinococcus granulosus ubiquitin specific protease 41 0.0078 0.0404 0.0992
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0105 0.0563 0.0563
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0072 0.0072
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0167 0.5
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.0005 0.0005
Mycobacterium tuberculosis Conserved protein 0.0578 0.3346 1
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0039 0.0039
Mycobacterium ulcerans transglutaminase family protein 0.0578 0.3346 1
Brugia malayi hypothetical protein 0.0037 0.0161 0.0467
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0307 0.1057
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0017
Schistosoma mansoni hypothetical protein 0.0066 0.0336 0.0814
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0078 0.0404 0.0745
Mycobacterium ulcerans hypothetical protein 0.0578 0.3346 1
Giardia lamblia Hypothetical protein 0.0578 0.3346 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0072 0.0201
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.0005 0.0017
Echinococcus multilocularis tumor protein p63 0.0367 0.2106 0.2106
Echinococcus granulosus lamin 0.0056 0.0274 0.0672
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0012 0.0018
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0104 0.0255
Loa Loa (eye worm) DR-78 0.001 0.0005 0.0017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0072 0.0249
Echinococcus granulosus GPCR family 2 0.0066 0.0336 0.0825
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0072 0.0201
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0404 0.0745
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0078 0.0404 0.6954
Brugia malayi Intermediate filament tail domain containing protein 0.0056 0.0274 0.0804
Schistosoma mansoni coup transcription factor 0.0022 0.0072 0.0165
Loa Loa (eye worm) hypothetical protein 0.0022 0.0072 0.0249
Mycobacterium leprae Conserved hypothetical protein 0.0578 0.3346 1
Brugia malayi jmjC domain containing protein 0.0016 0.0039 0.0101
Schistosoma mansoni hypothetical protein 0.0345 0.1976 0.4847
Brugia malayi Thioredoxin family protein 0.0578 0.3346 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0072 0.0165
Loa Loa (eye worm) hypothetical protein 0.0011 0.0012 0.0042
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.0049 0.012
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0072 0.0201
Brugia malayi Inositol-1 0.0038 0.0167 0.0484
Giardia lamblia Transglutaminase/protease, putative 0.0578 0.3346 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0072 0.0177
Schistosoma mansoni cpg binding protein 0.003 0.0123 0.0289
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0105 0.0563 0.0563
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0078 0.0404 0.1193
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0072 0.0201
Echinococcus multilocularis ubiquitin specific protease 41 0.0078 0.0404 0.0404
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0248 0.061
Schistosoma mansoni hypothetical protein 0.0066 0.0336 0.0814
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0248 0.0728
Loa Loa (eye worm) hypothetical protein 0.0011 0.0012 0.0042
Loa Loa (eye worm) hypothetical protein 0.0016 0.0039 0.0134
Schistosoma mansoni hypothetical protein 0.0345 0.1976 0.4847
Brugia malayi jmjC domain containing protein 0.0061 0.0307 0.0903
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0039 0.0083
Trypanosoma brucei developmentally regulated phosphoprotein 0.0105 0.0563 1
Echinococcus granulosus geminin 0.0345 0.1976 0.4853
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0005 0.0012
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0072 0.0165
Brugia malayi intermediate filament protein 0.0056 0.0274 0.0804
Schistosoma mansoni cpg binding protein 0.0032 0.0133 0.0314
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0072 0.0249
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.0005 0.0017
Brugia malayi hypothetical protein 0.0011 0.0012 0.0022
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0066 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.0066 0.0336 0.1157
Echinococcus granulosus microtubule associated protein 2 0.0701 0.407 1
Schistosoma mansoni jumonji domain containing protein 0.006 0.0297 0.0717
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0307 0.0742
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0037 0.0161 0.2333
Mycobacterium ulcerans putative transglutaminase-like protein 0.0578 0.3346 1
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0039 0.0083
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0078 0.0404 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0072 0.0249
Echinococcus multilocularis lamin 0.0056 0.0274 0.0274
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0039 0.0095
Brugia malayi jmjC domain containing protein 0.006 0.0297 0.0873
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0072 0.0177
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0167 0.0237
Mycobacterium tuberculosis Conserved hypothetical protein 0.0578 0.3346 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0261 0.0901
Schistosoma mansoni hypothetical protein 0.0143 0.0789 0.1929
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.0005 0.0017
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0039 0.0083
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0039 0.0039
Echinococcus multilocularis Transglutaminase 0.0578 0.3346 0.3346
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0066 0.0336 0.099
Schistosoma mansoni hypothetical protein 0.0578 0.3346 0.8218
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0078 0.0404 0.6954
Brugia malayi photoreceptor-specific nuclear receptor 0.0269 0.1531 0.4566
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0072 0.0072
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0307 0.0742
Mycobacterium ulcerans hypothetical protein 0.0578 0.3346 1
Schistosoma mansoni cpg binding protein 0.0032 0.0133 0.0314
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0072 0.0177
Loa Loa (eye worm) hypothetical protein 0.0269 0.1531 0.5275
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0017
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0072 0.0177
Echinococcus granulosus phd:f box containing protein 0.0016 0.0039 0.0095
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0039 0.0095
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0012 0.0018
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.0005 0.0012
Loa Loa (eye worm) inositol-1 0.0038 0.0167 0.0575
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0037 0.0161 0.5049
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0039 0.5
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0039 0.0039
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0005 0.0005
Echinococcus granulosus intermediate filament protein 0.0056 0.0274 0.0672
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0078 0.0404 0.0992
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0017
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.021 0.118 0.3517
Echinococcus granulosus lysine specific demethylase 5A 0.0061 0.0307 0.0754
Brugia malayi CXXC zinc finger family protein 0.003 0.0123 0.0352
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0248 0.0598
Onchocerca volvulus 0.0056 0.0274 0.03
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0072 0.0165
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0161 0.0161
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0072 0.0165
Schistosoma mansoni pyruvate dehydrogenase 0.0099 0.0529 0.1289
Loa Loa (eye worm) pigment dispersing factor receptor c 0.021 0.118 0.4066
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0039 0.0134
Brugia malayi hypothetical protein 0.0011 0.0012 0.0022
Mycobacterium tuberculosis Conserved hypothetical protein 0.0578 0.3346 1
Brugia malayi jmjC domain containing protein 0.0016 0.0039 0.0101
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0072 0.0201
Brugia malayi Latrophilin receptor protein 2 0.0066 0.0336 0.099
Brugia malayi kinase, mitochondrial precursor 0.0105 0.0563 0.1671
Schistosoma mansoni pyruvate dehydrogenase 0.0099 0.0529 0.1289
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0017
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0078 0.0404 0.0404
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0017
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0167 0.041
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0012 0.0042
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.006 0.0297 0.0297
Onchocerca volvulus 0.0056 0.0274 0.03
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0161 0.0384
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0167 0.5281
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.006 0.0297 0.0729
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0072 0.0075
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0072 0.0177
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0321 0.0778
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0005 0.0012
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0072 0.0177
Trichomonas vaginalis peptide N-glycanase, putative 0.0578 0.3346 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0248 0.0248
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0078 0.0404 0.0992
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0167 0.2441
Echinococcus granulosus tumor protein p63 0.0367 0.2106 0.5174
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0017
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0121 0.0417
Loa Loa (eye worm) hypothetical protein 0.0016 0.0039 0.0134
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0072 0.0249
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0078 0.0404 0.098
Loa Loa (eye worm) hypothetical protein 0.0078 0.0404 0.1391
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0248 0.0248
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0072 0.0165
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0017
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0167 0.2441
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0104 0.0104
Leishmania major developmentally regulated phosphoprotein-like protein 0.0105 0.0563 1
Schistosoma mansoni inositol monophosphatase 0.0038 0.0167 0.0398
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0072 0.0072
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0005 0.0012
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0121 0.0347
Loa Loa (eye worm) hypothetical protein 0.0022 0.0072 0.0249
Echinococcus multilocularis GPCR, family 2 0.0066 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.0105 0.0563 0.1941
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0072 0.0165
Brugia malayi nuclear receptor RXR 0.0011 0.0012 0.0022
Brugia malayi jmjC domain containing protein 0.0016 0.0039 0.0101
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0056 0.0274 0.0943
Loa Loa (eye worm) hypothetical protein 0.0022 0.0072 0.0249
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0072 0.0075
Loa Loa (eye worm) hypothetical protein 0.0022 0.0072 0.0249
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0037 0.0161 0.2333
Loa Loa (eye worm) hypothetical protein 0.0016 0.0039 0.0134
Loa Loa (eye worm) hypothetical protein 0.0011 0.0012 0.0042
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0167 0.2441
Onchocerca volvulus 0.003 0.0123 0.0131
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0043 0.0196 0.6468
Schistosoma mansoni inositol monophosphatase 0.0038 0.0167 0.0398
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0248 0.0598
Loa Loa (eye worm) hypothetical protein 0.0027 0.0104 0.0357
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.0005 0.0012
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.0005 0.0005
Mycobacterium tuberculosis Long conserved protein 0.0578 0.3346 1
Onchocerca volvulus 0.0054 0.0261 0.0286
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0072 0.0165
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0039 0.0039
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0039 0.0083
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0017
Loa Loa (eye worm) hypothetical protein 0.0026 0.0098 0.0336
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0072 0.0201
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0039 0.0134
Echinococcus multilocularis lamin dm0 0.0056 0.0274 0.0274
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0123 0.0422
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0017
Brugia malayi nuclear receptor NHR-88 0.0022 0.0072 0.0201
Schistosoma mansoni pyruvate dehydrogenase 0.0105 0.0563 0.1374
Brugia malayi Calcitonin receptor-like protein seb-1 0.021 0.118 0.3517
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0039 0.0095
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0072 0.0075
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0066 0.0336 0.0814
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0012 0.003
Schistosoma mansoni hypothetical protein 0.0066 0.0336 0.0814
Onchocerca volvulus 0.1534 0.8969 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0012 0.0042
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0066 0.0336 0.0825
Onchocerca volvulus 0.0022 0.0072 0.0075
Schistosoma mansoni lamin 0.0056 0.0274 0.0661
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0072 0.0249
Echinococcus multilocularis cpg binding protein 0.0032 0.0133 0.0133
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.0005 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0072 0.0201
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0105 0.0563 1
Brugia malayi latrophilin 2 splice variant baaae 0.0143 0.0789 0.2347
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0072 0.0072
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0167 0.2441
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0066 0.0336 0.0336
Brugia malayi ecdysteroid receptor 0.0022 0.0072 0.0201
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0072 0.0072
Schistosoma mansoni microtubule-associated protein tau 0.0701 0.407 1
Loa Loa (eye worm) intermediate filament protein 0.0056 0.0274 0.0943
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0072 0.0201
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0078 0.0404 0.098
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0012 0.0022
Echinococcus multilocularis microtubule associated protein 2 0.0701 0.407 0.407
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0072 0.0201
Echinococcus granulosus cpg binding protein 0.0032 0.0133 0.0326
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0078 0.0404 0.0745
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0012 0.0012
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.021 0.118 0.4066
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0039 0.0134
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0105 0.0563 0.1384
Schistosoma mansoni intermediate filament proteins 0.0056 0.0274 0.0661
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0072 0.0072
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0072 0.0177
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0072 0.0201
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0072 0.0072
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0072 0.0072
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0037 0.0161 0.2333
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.0005 0.0005

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 6.25 ug ml-1 Antimicrobial activity against Escherichia coli after 16 hr by serial dilution method ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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